Search PubMed⌕ Search

Biomedical subjects

W Ahmed

Publications and source records attributed to W Ahmed.

At least 55 records · Page 3Linked to original sources
PubMed1996

Triple therapy in duodenal ulcer healing--a follow up study.

Thirty-nine Helicobacter pylori (HP) positive chronic duodenal ulcer patients completed the 4 weeks treatment of triple therapy (Denol, Metronidazole and Amoxil). Of these 29 showed healed duodenal ulcer and negative CLO test at 8 weeks (eradication). They were followed at 3,6 and 12 months and at each follow-up, endoscopy and CLO testing were repeated. At 12 weeks, 54% showed a healed ulcer and negative CLO and these figures reached to 69 and 66% at 6 and 12 months respectively. Thirty percent relapsed within 1 year. The present study indicates a prolonged remission of duodenal ulcer following HP eradication.

Adult↗
PubMed1995

Healing and relapse rates of duodenal ulcer with omeprazole vs ranitidine.

The efficacy of omeprazole 20 mg a day was assessed against ranitidine 150 mg twice a day in the healing and relapse of duodenal ulcer. Forty three endoscopically verified cases were allocated to 2 weeks of treatment, which was extended to 4 weeks, if the ulcer persisted on day 15. Two cases were excluded due to deviation from the protocol. Of 41 evaluable cases, 21 received omeprazole and 20 ranitidine. Healing rates with omeprazole and ranitidine at 2 weeks were 71% and 70% respectively which rose to 100% and 90% at 4 weeks (N.S). There was no significant difference in pain relief in two groups. Follow-up endoscopies, in 33 healed cases revealed 100% relapse at 3 months in omeprazole and 79% in ranitidine treated cases (P < 0.05).

Adolescent↗
PubMed1995

Helicobacter pylori clearance and eradication with triple therapy in duodenal ulcer patients.

Triple therapy was given to 49 chronic helicobacter pylori positive chronic duodenal ulcer cases to see its efficacy in H. pylori clearance, eradication and ulcer healing. H. pylori clearance and eradication rates at week 5 and 8 were 87.8% and 81.5% while ulcer healing rates 68.2% and 81.5% respectively. Seven (18%) cases failed to clear H. pylori and were classified as non-responders. Histologically 60% showed post-treatment regression of gastritis. Tolerance to drugs was excellent with a good compliance rate.

Adult↗
PubMed1995

Famotidine 40mg B.I.D. in the treatment of reflux oesophagitis.

To assess the efficacy of famotidine in the healing of reflux oesophagitis, 25 endoscopically proven cases were treated with famotidine 40 mg B.I.D. for 6 to 12 weeks. Six patients were lost to follow-up, of the 19 cases analysed, 16 (84.2%) healed at 6 weeks and 17 (89.5%) at 12 weeks. Twelve cases (63%) became asymptomatic within six weeks of treatment. In conclusion famotidine 40 mg B.I.D. is effective in the healing of reflux oesophagitis.

Adolescent↗
PubMed1994

Isolation and characterization of saponins from Castanospermum australe Cunn. et Fraser.

Three new triterpenoid saponins, their methyl esters designated as castaralesides F (1), G (2) and H (3), were isolated from the fresh leaves of Castanospermum australe. The structures of these three saponins were elucidated on the basis of chemical and spectral data as 3 beta-O-[beta-galactopyranosyl-(1-->4)-beta-glucuronopyranosyl]-2 beta,23-dihydroxyolean-12-en-28-oic acid; 3 beta-O-[alpha-rhamnopyranosyl-(1-->4)-beta-galactopyranosyl-(1-->2)-beta - glucurono-pyranosyl]-2 beta,28-dihydroxyolean-12-ene; and 3 beta-O-[alpha-rhamnopyranosyl-(1-->4)-beta-xylopyranosyl-(1-->2)-beta- glucuronopyranosyl]-2 beta,28-dihydroxyolean-12-ene.

Carbohydrate Sequence↗
PubMed1993

Endoscopic lesions in chronic renal failure.

To determine the frequency and type of upper gastrointestinal lesions in patients with chronic renal failure (CRF), upper G.I. endoscopy was done in 101 cases. Of the various mucosal lesions, inflammatory changes were seen maximally (40), followed by erosions (16) and ulcers (7). Other changes included atrophic gastro-duodenal folds (17), pale mucosa (11) and moniliasis (6) which was only seen in patients with end stage CRF. Lesions were more frequent in those who were in advanced stage of CRF (81%) and those undergoing dialysis (79%), reflecting a positive correlation of upper G.I. lesions with the severity of CRF.

Adolescent↗
PubMed1993

Association of upper gastrointestinal lesions with addictions.

The association of upper gastrointestinal (G.I.) lesions with various addictions was studied in 383 consecutive patients endoscoped over a year. Of the total, 179 (47%) had no addictions and 204 (53%) were addicted to either cigarette smoking (70%), tobacco chewing with pan (23%), pan alone (5%) or alcohol (2%). Overall, 78% cases with and 59% without addictions had an upper G.I. lesion on endoscopy (P < 0.001). Duodenal ulcer was commonest lesion in all types of addiction.

Adult↗
PubMed1993

Omeprazole vs ranitidine in the healing of duodenal ulcer.

To assess the comparative efficacy of omeprazole 20 mg in the morning versus ranitidine 150 mg twice a day, in the healing of duodenal ulcer, 43 endoscopically verified cases were randomly allocated to 2 or 4 weeks (if ulcer did not heal at 2 weeks) treatment. Two cases were excluded due to deviation from the protocol. Of 21 cases treated with omeprazole 15 (71%) healed at two weeks and all (100%) at 4 weeks. Similarly of 20 cases treated with ranitidine, 14 (70%) healed at 2 and 18 (90%) at 4 weeks (P = NS). Two patients who did not heal with ranitidine, when crossed over to omeprazole healed at 4 weeks. No significant difference in the rate of pain relief, clinical or laboratory parameters or adverse effects were noted in either group. Both the drugs were well tolerated and were potent healer of duodenal ulcer; but omeprazole appears to be superior in the healing of resistent ulcers.

Adolescent↗
PubMed1992

H2 receptor antagonist or H. pylori eradication?

To assess the healing and relapse rate of duodenal ulcer (DU) treated with H2 receptor antagonists in helicobacter pylori (HP) positive vs negative cases, we analysed 95 cases of endoscopically proven duodenal ulcer. H. pylori colonization was found in 73 (77%) patients before treatment. No difference was observed in the pre-treatment characteristics between patients with HP positive and HP negative duodenal ulcers. Healing rates with H2 receptor antagonist at 8 weeks were 90% and 91% respectively (NS). No difference in HP colonization was found between patients with and without healed ulcerie, 77% and 78% respectively. Relapse rate within 1 year was 50% in patients with HP positive vs 73% with HP negative cases. We conclude that duodenal ulcer healing and relapse rate is related to acid inhibition rather than HP colonization.

Adult↗