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Biomedical subjects

W Adolph

Publications and source records attributed to W Adolph.

At least 19 recordsLinked to original sources

[Sonography of the thyroid].

The thyroid gland provides ideal anatomic conditions for sonographic investigations. Apart from the scintigraphy the sonography of the thyroid gland, therefore, stands in the first place as imaging procedure. After a short description of the investigation method and its ability of statement typical sonographic findings are demonstrated. The differentiation into diffuse or nodous strumata, the proof of typical focal findings such as autonomous adenomas or tumours or an increased vascularization in the region of the thyroid gland present an essential enlargement of the spectre of the modern diagnostics of the thyroid gland.

Diagnosis, Differential↗

[Changes of the gallbladder wall in the sonogram].

In the diagnostics of the changes of the gallbladder wall the sonography occupies a leading role. In acute cholecystitis on the basis of the criteria mentioned the making of a diagnosis is possible. Polypoid or plane-like infiltrating changes of the wall of the gallbladder are ambiguous and with the exception of the cholesterol polyps they are sonographically not always to be differentiated with sufficient certainty as benign (adenomas) or malignant (carcinomas) formations. When there is the least doubt about the dignity of the lesion of the gallbladder wall the continuing diagnostics (ERCP, CT) or the cholecystectomy is to be demanded.

Cholecystitis↗

[Tracheobronchomegaly--a case report].

On the basis of a casuistics is referred to the infrequent tracheobronchomegaly with disturbed respiratory mechanics (tracheal collapse) and relapsing bronchitides due to a congenital or acquired loss of elasticity of trachea and main bronchi. Bronchoscopy and bronchography ascertain the diagnosis which may be supposed already on the full-size X-ray by the demonstration of an abnormally wide trachea. The conservative therapy of the in most cases mucopurulent bronchitis for the purpose of the prevention of a global respiratory insufficiency apart from mucolytics often demands the application of antibiotics. In individual cases the prognosis may be improved by stabilizing operative corrections of the trachea and the resection treatment of accompanying bronchiectases.

Bronchitis↗

[Ultrasonic diagnosis in aneurysm of the abdominal aorta].

The sonographic diagnostics of an aneurysm of the abdominal aorta has obtained a high value on account of the high reliability and the rapid availability of the investigation in connection with the absolute safety of the method. Form, extension, calcification, haemodynamics, thrombosis and dissection of an aneurysm of the aorta can sonographically be demonstrated and measured by longitudinal and transversal sections. As non-invasive approach the ultrasound tomography in the order of the graduated diagnostic method stands before the computed tomography which is not always at once available and before the angiography which have their qualification in the case of a planned operative approach above all for the purpose of the exact topographic differentiation between suprarenal and infrarenal extension.

Aorta, Abdominal↗

[Ultrasound study of the spleen].

The sonography is the method of choice for the determination of the size of the spleen. Normally, this has, represented from the left flank, a size of 12 x 5 cm (length and thickness) and a regular structural pattern. Splenomegalies with diffusely changed echo-structure are found in infections, congestion spleens as well as haemoblastoses. Focal lesions are typical for cysts, abscesses and haematomas of the spleen. The sonography of the spleen plays a particular role in the staging of malignant lymphomas, whereas metastatic changes of the spleen may more infrequently be stated sonographically. The authors deal with the great importance of the sonography of the spleen in abdominal traumas.

Humans↗

[Percutaneous transhepatic bile duct drainage (PTCD)].

At the instance of a female patient with obstructive jaundice due to inoperable carcinoma of the head of the pancreas is reported on the percutaneous transhepatic cholangiodrainage. With the help of this non-operative palliative drainage of the system of bile ducts in malignant tumors of the biliopancreatic area an at least transitory relief with regression of the jaundice and the excruciating pruritus is achieved. With regard to the relatively high complication rate of the percutaneous drainages performed without laparotomy (haemorrhage, cholangitis, sepsis) and to the possibly already early loss of function by occlusion or dislocation of the catheter the indication for such an approach is strictly to be made.

Aged↗

[Gastroduodenal Crohn disease. Presentation with a case report].

On the basis of a casuistics the infrequent isolated manifestation of a morbus Crohn in the duodenum is discussed. Apart from the clinical symptomatology the radiological and endoscopic proof of a segmentary stenosis is the most important diagnostic reference. The histological ascertainment of the granulomatous inflammation by aimed endoscopic biopsies is successful only at a low percentage, so that the synopsis of the findings is decisive for the diagnosis.

Adult↗

[Results of a population study of non-insulin dependent diabetes mellitus in childhood and adolescence].

Among 40 927 diabetics centrally registered in the Erfurt district, 61 non-insulin-dependent diabetics (0.15%) in early life have been recorded. The age of onset of 58 examined patients (36 males, 22 females) was 10 to 24 years. The insulin secretion after a 50 g oral glucose load varied markedly and corresponded to a control group of 62 adult NIDDM patients. 76.4% of the patients had a diabetic parent. In 17 patients (30%) diabetes had been transmitted through at least three generations. Sporadic occurrence was found in 19% of the case material. Families of MASON type with a marked diabetes accumulation were observed in only 3 cases. In the HLA system (A, B and C locus) there were characteristic differences from insulin-dependent diabetics but no significant (Pcorr) differences in comparison to the normal population. Variations of heredity, as well as differences in body weight, insulin secretion and varying susceptibility to vascular complication suggest that NIDDM in early life is a heterogeneous disorder. Besides the early age of onset, the balanced sex ratio and the partly marked inheritance, most patients of this population study present the typical features of type 2 diabetes.

Adolescent↗

[Chlorpropamide-alcohol flush test in non-insulin-dependent diabetes mellitus in young age (MODY type)].

The chlorpropamide alcohol flush test (CPAF) has been described as a dominantly inherited feature in NIDDM, particularly of young people (MODY-type). Validity and usefulness of the CPAF were analyzed in 40 MODY-patients recruiting from a population study (criteria acc. to Tattersall and Fajans, 1975), 59 first degree relatives (24 diabetics, 35 non-diabetics), 40 NIDDM of maturity onset, 40 IDDM, and 40 healthy controls. The CPAF (single challenge test, placebo control, subjective evaluation by questionnaire acc. to Köbberling, 1980) proved to be positive in only 8 MODY-patients and 5 of diabetic first-degree relatives. In comparison to NIDDM of maturity onset (40/8), IDDM (40/6) and healthy controls (40/2) the frequency of positive CPAF showed no significant differences. Between flushers and non-flushers within the MODY-group no relationship to vascular findings, metabolic and genetic data (including HLA-typing) could be found. It is concluded that the CPAF is a real but rather nonspecific phenomenon unsuitable as a genetic marker.

Adolescent↗

[Double pylorus].

It is reported on the endoscopic proof of a double pylorus in a 57-year-old patient. The anamnesis of ulcer of many years and a florid prepyloric gastric ulcer refer to the ulcerous origin of this anomaly. It is referred to the diagnostic importance of the gastroscopy of the acquired or congenital duplication of the pylorus channel which is difficult to be represented radiologically with regard to the avoidance of possible diagnostic errors (e.g. carcinoma of the antrum).

Gastric Fistula↗

[Intensified therapy of newly detected maturity onset diabetes].

In a prospective study 150 newly detected maturity onset-diabetics were randomized in 2 biostatistically comparable groups and underwent a treatment of different intensity. While the patients of the control group were treated according to the routine method used up to now in the dispensary for diabetics, in the intervention group an intensifying of the therapy took place, taking particular into consideration the body weight as well as the carbohydrate and fat metabolism. The decrease of body weight achieved by dietary intensive care proved to be the decisive factor for the tendency towards normalisation of glucose tolerance, hyperlipoproteinaemia and IRI-secretion, which could be registered in the intervention group after 2 years of observation. Following the preceding strong phase of diet, by Biguanides and Clofibrate a further significant improvement of the carbohydrate and fat metabolism could not be achieved. The decisive reserve in the treatment of obese maturity onset-diabetes could be seen in a permanent and continuous reduction of body weight. The results of this treatment depend highly on an intensive education as well as on frequent control of the patients' metabolism and their cooperation.

Biguanides↗

[Lactacidosis in guanide treatment--a current disease syndrome].

It is reported on two eldery female diabetics with severe lethal lactacidosis. The clinical picture as well as the laboratory constellation leave no room for doubt about it, though only in one case the estimation of lactate could be performed. A renal insufficiency as involving factor is to be supposed in the two cases. With the help of literature the essential points of view of the clinical picture are discussed and it is referred to its origin also under influence of buformin.

Acidosis↗