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Biomedical subjects

Viroj Wiwanitkit

Publications and source records attributed to Viroj Wiwanitkit.

At least 37 records · Page 2Linked to original sources
PubMed2006

Urine glycosyl albumin formation: relation to severe nephropathy in the poor control diabetes mellitus patients?

Diabetes mellitus (DM) is a frequent disorder affecting individuals of all ages. Urine glycosyl albumin is an important finding in the patients with severe diabetic nephropathy. In addition, accumulation of glycated albumin in end-stage renal failure is noted. Here, the author performed a reappraisal on the bonding energy based on quantum chemical analysis. The author calculated the bonding energy of the reaction and found that the reaction is a type of "energy providing reaction." The author hereby proposed that the nature of energy providing reaction in formation of glycosyl albumin can be an insult to the surrounding renal tissues in poorly controlled DM patients. Giving out the energy from the nearby cellular compartment during formation of glycosyl albumin might be an important pathological process leading to severe diabetic nephropathy and renal failure.

Albuminuria↗
PubMed2006

IgA-CD89 complex in IgA nephropathy: a study on molecular function.

IgA nephropathy is the most common form of primary glomerulonephritis worldwide. The basic pathogenesis of this disease is believed to be due to the complex formation between Fc IgA, alphaRI (CD89), and transferrin receptor (CD71), leading to the damage of the glomerulus. However, studying the functional aberration in the human IgA, CD89, and CD71 complex formation in pathogenesis of IgA nephropathy is hard. Here, the author used a new gene ontology technology to predict the molecular function of human IgA, CD89, and CD71 complex. It can be seen that the two main functional aberrations of IgA-CD89 complex might be due to signal transduction and binding activity.

Antigen-Antibody Complex↗
PubMed2006

Effect of immune complex on the biomechanics of blood flow in common glomerulonephritis diseases.

Glomerulonephritis (GN) is a common nephrological disorder. The correlation between degree of glomerular damage, severity of GN, and development of hypertension is an interesting topic in present research on GN. Although the progression of GN is proved to associate with hypertension, no clear pathogenesis is reported. In this study, the author assesses the effect of various sizes of immune complex in three common GN diseases on the biomechanics of blood flow in the renal vascular. Further discussion on the impact on hypertension is also provided.

Antigen-Antibody Complex↗
PubMed2006

Angiotensin-converting enzyme gene polymorphism is correlated to the progression of disease in patients with IgA nephropathy: a meta-analysis.

Angiotensin-converting enzyme (ACE) displays potent vasoconstrictive effects, attenuation of fibrinolysis, and platelet activation and aggregation. Recently it was mentioned that the insertion/deletion polymorphism of the ACE gene is associated with ESRD. The lengthy course of IgA Nephropathy (IgAN) and the possibility of good outcomes without therapy suggest nontoxic therapies such as ACE inhibitors and angiotensin receptor blockers (ARBs). However, the correlation between the ACE gene polymorphism and progression of IgAN still requires further approval. Here, the author performs a summative analysis on the recent previous reports on the ACE gene polymorphism and its correlation to progression of IgAN. The meta-analysis was performed to assess the correlation between the pattern of ACE gene polymorphism and progression of IgAN. From five available studies, 346 and 555 patients with (group 1) and without (group 2) the progression of disease are evaluated. According to this study, the frequency of DD genotype in group 1 is significant higher than group 2 (p < 0.05). In addition, the author first reports a non-significant correlation between the ethnicity and the ACE gene polymorphism.

Asian People↗
PubMed2006

White blood cell sister chromatid exchange among a sample of Thai subjects exposed to toluene, an observation.

There is a particular concern with toluene because some research has indicated that toluene exposure could result in chronic toxicity including mutagenesis and carcinogenesis. This study aimed to determine the rate of sister chromatid exchanges (SCE), a marker for genotoxicity, and its correlation to the classical urine biomarker for toluene exposure, urine hippuric acid, among a sample of Thai exposed subjects. A total of 26 police (all males) were included in this study. The average (mean +/- SD) urine hippuric acid level in these police was 0.8 +/- 0.4 mg/g creatinine. The average (mean +/- SD) SCE level in these police was 4.5 +/- 1.0/cell. The average SCE among the police with high urine hippuric acid levels was non-significantly higher than the average SCE level of those without (P = 0.41). This implies that the cytogenetic response to toluene was not different between the subjects with and without high toluene exposure. High exposure to toluene seems not to be related to high SCE.

Adult↗
PubMed2006

Congenital malaria in Thailand, an appraisal of previous cases.

BACKGROUND: Malaria is an important vector-borne infectious disease. Many tropical countries are the endemic area of malaria. Thailand, a tropical country in Southeast Asia, is the well-known endemic area for malaria. Although Thailand has a high prevalence of malaria, few cases of congenital malaria were reported in the past. METHODS: Here, the author performed a literature review of the reports of congenital malaria in Thailand in order to summarize the characteristics of this infection among Thai patients. RESULTS: According to this study, there have been at least six reports in the literature of 27 cases of congenital malaria infection in the Thai population, of which no case was lethal. There were 22 vivax (81.5%) and five falciparum (18.5%) malarial cases. The details on clinical presentations of these cases are presented and discussed. CONCLUSION: According to this study, it can be seen that congenital malaria may occur in the absence of clinical symptoms in mothers as well as their children. Concerning the species of malaria, the vivax malaria is more common in this case series.

Adult↗
PubMed2006

Extreme thrombocytosis: what are the etiologies?

Increase platelet count or thrombocytosis, defined as a platelet count greater than or equal to 350 x 10(9)/L, is a common hematologic aberration seen in complete blood cell count. Several etiologies are documented for thrombocytosis. Extreme thrombocytosis, defined as a platelet count greater than or equal to 1,000 x 10(9)/L, is rarely seen in general practice. There are limited data on the etiology of this abnormality. Here, a retrospective investigation for the etiology of severe thrombocytosis was performed. Of the 3 included reports, 535 cases with extreme thrombocytosis were investigated for their etiologies. The 2 defined etiologies are secondary thrombocytosis (66.6%) and clonal thrombocytosis. Of those cases with clonal thrombocytosis, 93.8% had myeloproliferative disorders, and 6.2% had essential thrombocytosis. Concerning bleeding and vaso-occlusive complications, all cases had these complications. In this study, 7.9% of the cases with secondary thrombocytosis experienced bleeding and vaso-occlusive complications, while 17.1% of the cases with clonal thrombocytosis did.

Clone Cells↗
PubMed2006

PIA1/A2 polymorphism of the platelet glycoprotein receptor IIb/IIIIa and its correlation with myocardial infarction: an appraisal.

Platelet glycoprotein (GP) IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor. There is considerable controversy regarding the clinical role of the GPIIb/IIIa PIA1/A2 as a risk factor for myocardial infarction. A summative analysis is performed on the recent previous reports on the GPIIb/IIIa PIA1/A2 and its correlation to myocardial infarction. The metanalysis was performed to assess the correlation between the pattern of GPIIb/IIIa PIA1/A2 polymorphism and myocardial infarction. From 7 available case-control reports, 553 patients and 1,059 controls are evaluated. The overall frequencies of PIA2 allele for the patients and controls are 0.249 and 0.221, respectively. According to this study, 49.4% of subjects with PIA2 allele have myocardial infarction while 39.5% of subjects without PIA2 allele have cerebrovascular disease. From overall risk estimation, the subjects with PIA2 alleles have a 1.1 times higher risk to have myocardial infarction. According to this analysis, it is proposed that the pattern of GPIIb/IIIa PIA1/A2 polymorphism does not represent a useful marker of increased risk for myocardial infarction. In addition, the lack of association between the pattern of GPIIb/IIIa PIA1/A2 polymorphism and ethnicity of the patients was demonstrated in this study.

Case-Control Studies↗
PubMed2006

Pharmacogenomic effect of cytochrome P450 2C9 polymorphisms in different populations.

Presently, warfarin sodium or coumadin is the therapeutic drug of choice for maintenance anticoagualtion therapy. One of several factors underlying the variability in warfarin dose response in the patients receiving this oral anticoagulant is a genetic predisposition, especially the CYP2C9 polymorphisms. The pharmacogenomic effect of CYP2C9 polymorphisms is assessed in different racial populations. A retrospective review was performed with an electronic search engine on this topic to get the data for further meta-analysis. A significant correlation between population ethnicity and gene frequencies was detected in this study. A significant low frequency of CYP2C9 variants among the Asian can be demonstrated. The clinical correlation between CYP2C9 polymorphism and warfarin metabolism was also assessed. Four available case-control reports were selected for this meta-analysis. CYP2C9 variants are strongly associated with low-dose warfarin requirement. In summary, the CYP2C9 variants strongly affect the warfarin dose requirement. This phenomenon is ethnically dependent. Due to the high variant frequency among whites in the West, the investigation for CYP2C9 might be useful for this population, not the Asians, whose variant frequency is very low.

Anticoagulants↗
PubMed2006

Spectrum of bleeding in acquired factor V inhibitor: a summary of 33 cases.

Coagulation factor V (FV) is an essential component of the prothrombinase complex, which activates the zymogen prothrombin to thrombin. Acquired FV inhibitor is rare and clinical symptoms are quite variable. The aim of this study was to summarize the spectrum of the bleeding presentation of acquired FV deficiency and characterize the underlying causes of the clinical symptoms. This study was designed as a descriptive retrospective and 30 case reports were included for further analysis. At least 33 cases of acquired FV inhibitor were investigated. Most patients have a presentation of bleeding and most of those are from hematuria and bleeding at surgical sites. Seven cases of asymptomatic acquired FV inhibitor were also detected. A total of 39.4% (19 of 33) of those cases with acquired FV inhibitor have an unknown cause. For those with known etiologies, chemical and drug-induced causes are the most common (30.8%).

Anti-Bacterial Agents↗
PubMed2006

Intestinal parasite infestation in HIV infected patients.

One of the major health problems among HIV-infected patients is the intestinal parasite infestations. It can be seen that intestinal helminth infestation in HIV-infected patients is common. However, the reported prevalence is usually similar to those of non HIV-infected patients in the same setting. The infestations are ordinary not opportunistic, hence, thus usually show no correlation to immune status of the patients. The suppression of immunity due to HIV infection shows no significant role in increasing the intestinal helminth infestations. On the other hand, having occult intestinal helminth infestations does also not worsen the outcome of HIV infection. Concerning the clinical manifestation, most of the helminth infestations are asymptomatic and the diagnosis is usually based on the stool examination. Treatments of the infestations as well as the outcomes are usually similar to immunocompetent host. Intestinal protozoa infestations are also important problems for HIV-infected patients. Some infections are ordinary, while the others are opportunistic infection. The important opportunistic intestinal parasites including C. parvum, I. belli, Cyclospora and the Microsporidia are found at high prevalence among the HIV-infected patients, especially in low immune cases with persistent diarrhea. Concerning the clinical manifestation, most of the infestations bring diarrhea and the diagnosis is usually based on the stool examination with special stains. The treatment of the opportunistic infection can usually get control of the present illness but not prevent the re-infection. Luckily, with the present wide distribution of HAART, the prevalence of the opportunistic intestinal protozoa infections is significantly decreased.

AIDS-Related Opportunistic Infections↗