[Secondary hyperparathyroidism prevention in chronic renal insufficiency (author's transl)].
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Biomedical subjects
Publications and source records attributed to V Zvara.
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An epidemiological and clinical study of a sample of 105 children with urolithiasis treated in the period 1965-1974 in a defined population of children revealed a decrease in the rate of incidence of this disease in a municipal infant population with high-ranking care for their health. Serious forms of urolithiasis are on the decrease. There is a higher rate of incidence in schoolboys and schoolgirls, the latter being more often involved than boys. Despite the general lower rate of occurrence, urolithiasis still has such forms as will endanger the life of the organ and the life of the patient. Injury to health of the child by this disease consists mainly in loss of one kidney, ambilateral staghorn stones that proved irremovable in their entirety and pyelonephritis.
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Several serum and urinary constitutents were evaluated in 13 calcium oxalate kidney stone formers in whom according to urinary vitamin B6 excretion sufficient vitamin B6 intake before the study was suggested. The influence of 28-day Pyridoxine (Spofa) supplementation (20 mg three times daily) on these biochemical parameters was searched. Pyridoxine supplementation was followed by a significant increment in the mean values of serum uric acid; the remaining serum constitutents did not change. Urinary calcium, phosphare, magnesium, sodium, potassium, and uric acid slightly increased, urinary oxalate excretion slightly fell; there was a high variability in the changes between the individuals. No changes in the mean values of clearance of endogenous creatinine, percentage of tubular reabsorption of phosphate and urinary zinc excretion were found. It is suggested that long-term studies are necessary to search the factors influencing successful stone prevention or stone recurrency in pyridoxine-treatment patients.
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Intractable haemorrhages of the bladder in consequence of wide-spread tumours or of haemorrhagic cystitis secondary to radiation therapy involve serious therapeutic problems. Failure of the conventional therapy to bring the haemorrhage under control imposes more active measures so as to avert the danger of exsanguination. The condition of the patients is, however, generally incompatible with major surgery. In this situation the authors resorted to the hydrostatic pressure technique and to intravesical instillations of formalin. Their observations with these procedures are reported.
In a group of 57 children with urolithiasis hypomagnesaemia was found in 15 cases (26.3%). All children but one with abnormally low serum magnesium levels had recurrent or bilateral nephrolithiasis or nephrocalcinosis. Prevalence of hyperoxaluria and hypercalciuria, marked severity of the clinical features, abnormality of Ca metabolism and its responsiveness to MgO treatment were demonstrable in Mg deficiency.
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