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Biomedical subjects

V Ziegler

Publications and source records attributed to V Ziegler.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Selected problems in the experimental evaluation of the skin-irritating effect of industrial substances].

Basing on the determination of ID50 and IT50 after Kligman and Wooding but involving our own modification, the primarily irritating effect of certain industrial substances on experimental animals' and humans' skin was comparatively evaluated. Mutual experimental studies have been carried out in Dermatological Clinics in Leipzig and Rostock and Dermatological Clinic at the Medical Academy of Lódź. The results were found to be generally consistent in humans and animals. Extension of international cooperation and information and results on the determination of industrial substances adverse effects seem to be necessary.

Allergens↗
PubMed1980

[Methodical problems in detecting new allergens in ;animal experiments (author's transl)].

With the help of the Tina-test partial aspects of the predictive testing of potential allergens were examined in animal experiments. The Tina-test is based on the intramuscular, intracutaneous and epicutaneous application of the allergen in question using Freund's adjuvant and sodium laurylsulphate. The test has been acknowledged by the authorities as a standardized method. the following aspects were examined. A prolongation of the exposition times causes an increase of the sensitization rates. Freund's adjuvant should be used in every case, since the percentage of sensitized animals may be clearly increased. Outbred guinea pigs are well suited. the use of inbred animals is not necessary. In cases where more than 30% of the experimental group fall ill during the procedure of sensitization, the results are not reliable. Neither the sex of the animals nor the seasons influence sensitization rates. Per experimental group at least 25 animals should be used. Pilot studies with different quantities of allergens (potassium bichromate: 131 mg: 13.1 mg and 1.31 mg) did not show a clear influence on the results. Similar results we received also with nickel-2-sulphate. The sensitization rate corresponded well with our clinical experience in 19 out of 24 substances. With turpentine, nickel, mercury and a low-molecular phenol resin the number of the sensitized animals was somewhat too low, whereas with tetramethylthiuramdisulfide the percentage was somewhat too high.

Allergens↗
PubMed1978

[Dermatological incompatibility reaction to X5Cr-Ni-Mo 18.10 steel implants in animal experiments].

Metal allergy is surveyed in detail. Especially the development of eczema by means of metallic implantates containing chromium or nickel. The results from two series of experiments on guinea-pigs are presented. The first series proves that after preceding sensibilization by potassium bichromate or nickel-II-sulfate eczemas may be induced in the guinea-pig by X 5 Cr Ni Mo 18.10 steel implantates. Positive skin reactions in the patch test prove the possibility of sensibilization by X 5 Cr Ni Mo 18.10 steel in a second series of animals preoperatively negative.

Animals↗