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Biomedical subjects

V Zeman

Publications and source records attributed to V Zeman.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Medullary carcinoma of the thyroid gland with Cushing's syndrome].

The authors describe generalized medullary carcinoma of the thyroid gland with a typical slow 23-year progression which due to prolonged hypercortisolism led to the development of classical "paraneoplastic" Cushing's syndrome. The authors describe the diagnostic difficulties as regards laboratory tests. The case confirms not only the need of early radical treatment of these carcinomas which is the optimal solution, which however can be implemented only in exceptional instances, but also of the detection of this syndrome in all patients with medullary carcinoma of the thyroid in the preclinical stage. Clinically developed Cushing's syndrome or hypokalaemic alkalosis are in the majority of cases a late symptom associated as a rule with advanced generalization of this carcinoma.

Adult↗
PubMed1980

[Unusual cause of death of a parturient from circulatory failure (author's transl)].

Bilateral phaeochromocytoma was histologically recorded from a primigravida and primipara, 22 years of ager, who had died 13 hours after precipitate spontaneous birth of a living mature child. Mucosal neurofibroma on the tongue and solid medullary carcinoma of the thyroid gland with amyloid, associated with Hashimoto's lymphocytic thyreoiditis, were additional findings. Coincidence of such carcinoma with Hashimoto's thyreoiditis so far has not been described in international literature. When the abdominal cavity was relieved of pressure after parturition, bleeding started into the phaeochromocytoma on the left side. Death then was caused by resulting peripheral circulatory failure.

Adrenal Gland Neoplasms↗
PubMed1980

Thyroidectomy as a pathogenic factor in the evolution of thyroid cancer.

In a group fo 860 patients with thyroid cancers (TC), 66 were found having had thyroid surgery for benign disorder more than 5 years before the diagnosis of TC. More than 70% of these patients were operated upon 10 or more years ago. The incidence of cancers developing in thyroid postsurgical remnants could thus be estimated to 5.5-7.7% of all thyroid cancers. These patients had predominantly follicular cancers and usually were older than 40 years at the age of diagnosis of TC. Unusually high incidence of distant metastases (pulmonary or osseous) was proved compared to other patients with TC, while the increase of patients having both pulmonary and osseous metastases was not found. It seems that the risk of developing TC late after thyroid surgery is somehow connected with endemic goitre areas, as all such reports arise from the central European area. Whichever the pathogenic mechanism may be, all patients following surgery for benign eumetabolic goitres should be checked up in regular intervals with regard to the possible benign or malignant recurrence. Patients operated upon because of hyperthyroidism do not seem to carry any similar risk.

Adenocarcinoma↗
PubMed1980

Metastatic thyroid cancer with severe hyperthyroidism mimicking independent hyperfunctioning thyroid adenoma, showing transition to water-clear-tumour.

A case of different thyroid cancer is reported in detail, showing unusual behaviour both clinically and bioptically. The patient suffered from severe hyperthyroidism, with a scintigraphic finding of independent thyroid adenoma and simultaneous function in pelvic mass proved to be a metastasis of follicular thyroid cancer. Bioptical finding confirmed the aspiration biopsy conclusion that the independently functioning thyroid nodule had been in fact a follicular thyroid cancer. Microscopically, a transition of the usual type of follicular thyroid cancer to solid cancer consisting of water-clear cells was found. Thyroidectomy led to enhancement of uptake in pelvic metastasis but the general condition deteriorated rapidly leading to death by pulmonary embolism. The problem is discussed with regard to the development of hyperthyroidism in thyroid cancer.

Adenoma↗
PubMed1980

Fully developed picture of Cushing's syndrome in a female patient with medullary carcinoma of the thyroid gland: some diagnostic difficulties in this paraneoplastic syndrome.

The authors present a further description of the classical picture of Cushing's syndrome in a female patient with medullary carcinoma of the thyroid gland (MCT). Analysis of data reported in the literature and the author's own experience indicate the necessity of radical treatment of MCT before the development of the clinical paraneoplastic syndrome and of efforts to detect it in the preclinical stage. Developed Cushing's syndrome or hypokalaemic alkalosis are in the great majority late symptoms associated as a rule with advanced dissemination of the tumour. Metastases in the liver are particularly frequent. As regards therapy, bilateral adrenalectomy is recommended when it is obvious that attempts to eradicate MCT are hopeless, even where the affection of the adrenals seems to be unilateral. Radical surgery of the tumour and of regional metastases, if there is no remote dissemination, is the optimal solution, which can be used, however, only in exceptional cases.

Adrenal Glands↗
PubMed1979

Mode of spread of thyroid cancer.

Metastatic dissemination of differentiated cancer was studied in a personal group with the following results. Invasion of cancer to adjacent structures can be encountered even in children with typical increase with age. The lymphatic spread to regional lymph nodes is typical of papillary cancers and in young patients. The same type of spread without the age-dependent decrease can also be proved, with lower incidence, in follicular cancers. Pulmonary metastases are frequently the only type of distant metastases and may originate from previous spread to lymph nodes. The isolated bone metastases a;e probably brought about through the vertebral venous system. Patients having multiple bone metastases or both bone and lung lesions are probably the only typical examples of metastasizing through the systemic blood flow. As the above types of distant metastases carry different prognosis they should also be recognized by the TNM system.

Adult↗