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Biomedical subjects

V Wagner

Publications and source records attributed to V Wagner.

At least 109 records · Page 6Linked to original sources
PubMed1975

Transformation of lymphocytes in patients with certain bacterial infections.

The state of cell-mediated immunity was measured by the morphological method of lymphocyte transformation with and without PHA, in a group of 56 patients with bacterial infections and in a group of healthy controls. The patients were divided into three subgroups according to the aetiology: 1. Patients with Gram-positive infections, 2. Patients with Gram-negative infections, and 3. mixed infections. The transformation values with PHA were significantly (t-test) higher in the Gram-positive subgroups than in the control group. Transformation in cultures stimulated by PHA was much higher in the subgroup of patients with Gram-positive aetiology; the difference between the values in the Gram-negative and in the Gram-positive subgroups was also significant. A decrease of transformation value below 50% was observed in 6 out of 18 patients with Gram-negative aetiology, whereas in the Gram-positive group it was noted in only 2 out of 21 patients.

Escherichia coli Infections↗
PubMed1975

Dispersed rat parotid acinar cells. II. Characterization of adrenergic receptors.

The in vitro characterization of adrenergic receptors in isolated rat parotid acinar cells was accomplished through investigations of the transmembrane influxes of K and of the secretion of amylase in response to interactions of the cells with selected agonists and antagonists. Interaction of epinephrine (EPI) at concentrations of 10(-3)-10(-9) M with the alpha-adrenergic receptors resulted in rapid efflux of K from the cells. This effect was inhibited by phentolamine but not by propranolol or atropine. The process of secretion of amylase by these cells involved the activation of the beta-adrenergic receptors by the adrenergic agonists DL-isoproterenol (IPR) and EPI at similar to above concentrations. The interaction of these agonists with the beta receptors was inhibited by propranolol but not by phentolamine or atropine. Dibutyryl clclic AMP stimulated secretion of amylase at concentrations of 10(-8) M. A progressive increase in the secretory response of the cells was observed with increases in the dibutyryl cyclic AMP concentrations up to 10(-5) M. This effect was not inhibited by propranolol. This study demonstrates that dispersed rat parotid acinar cells have functionally intact adrenergic receptors and could be used as experimental tools for the studies of receptor physiology and pharmacology as well as other aspects of secretion at the cellular level.

Amylases↗
PubMed1975

Investigation of immunoglobulin (IgG, IgA, IgM) levels in the blood serum of uranium miners after higher and lower exposure to ionizing radiation.

The levels of IgG, IgA and IgM were measured in the blood serum of uranium miners in a minin-district, where after a geological disturbance exposure to a high level of ionizing radiation took place. The mean exposure to 222-Rn daughters after first year was 7.35 WLM, after the second year 0.13 WLM only. Serum was sampled before miners started their occupation, for the second time after the first year and for the third time after the second year. The levels of IgG and IgM significantly decreased after one year of exposure, while the IgA changed only slightly. After the second year the levels of IgG and IgM significantly rose. IgG exceeded the initial levels: a regenerative hypercompensation took place. On the other hand IgA at the same time decreased. The IgG levels are only slightly correlated with radiation dose rate; for IgA and IgM the correlation is lacking. Individual Ig levels appear to be very variable. The reduction of IgG reached hypogammaglobulinemic levels in some miners after the first year and was followed by a propensity to infections of the respiratory tract. The significance of these observations is discussed from the immunological, radiological and radiohygienical point of view.

Accidents, Occupational↗
PubMed1975

Serum immunoglobulin levels in cancer patients. I. Serum immunoglobulins and primary tumor localization.

A comparison was made between the mean values of immunoglobulin IgG, IgA and IgM in patients sera in various primary localizations of malignant tumors. The values ranged generally above the upper limit stated for the so-called healthy population, the highest being in Ca of kidneys of Grawitz type, Ca laryngis and Co bronchogenes. In the IgG class higher values appeared mainly in Grawitz tumor, however, a certain elevated level with respect to the other groups of malignancies occurred also in Ca vesicae urinariae and in Ca bronchogenes, but the differences are without statistical significance. No changes were observed in the IgM group.

Antibodies, Neoplasm↗
PubMed1975

Immunoglobulins under the influence of nonspecific factors II. The influence of work-stress on levels of immunoglobulins (IgG, IgA, IgM) of miners in uranium mines.

In 2 groups of 22 miners each, exposed 5.4 and 10.8 years respectively to the environment of uranium mines, the serum levels of IgG, IgA, and IgM were measured before and after one workshift. In the group longer exposed the work-stress resulted in a significant decrease of all 3 classes of Ig. In the group exposed for a shorter time only the IgG decreased significantly. In the group longer exposed the initial levels of IgG were considerably lower in comparison with the group exposed for a shorter time.

Adult↗
PubMed1975

Immunoglobulin (IgG, IgA, IgM) values in a few population groups.

Certain significant differences were found between the mean IgG levels in four different population groups. No differences were found in the IgA and IgM classes. The highest IgG levels were found in food workers and the lowest levels in coal-miners working at the face. Surface mine employees and employees just taken on for underground work had intermediate values. On dividing the population groups into age sub-groups, significant differences were found between some of the latter. Physical stress, differences in exposure to infections, the influence of the macro- and micro-climate and spontaneous and controlled selection for given occupations are regarded as possible causes of the observed differences.

Adult↗