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Biomedical subjects

V V Maleev

Publications and source records attributed to V V Maleev.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Clinico-hemostatic characteristics of serum disease in toxic forms of diphtheria].

Coagulative changes at the height of serum disease were investigated in 28 patients with severe diphtheria. It was found that on day 10 after first injection of diphtheria antitoxin hemocoagulation underwent activation with prevailing thrombogenesis coinciding in time with acute period of serum disease. The severity of serum complications correlated with the degree of coagulation activity. A relationship exists between the amount of the given antitoxin, duration of hormone therapy and occurrence of serum complications. There were specific for serum disease biochemical alterations indicative of destruction of blood cells and vascular-endothelial structures on the disease day 12-14.

Acute Disease↗
PubMed1994

[Disorders in the plasma and cellular hemostatic components of patients with HIV infection].

Plasmic and platelet components of hemostasis were investigated in 100 HIV-infected subjects. Its degree depended on the infection stage and associated opportunistic infections. The key factor in pathogenesis of hemocoagulatory disorders is reduced count, abnormal function and morphology of platelets. A direct relationship exists between the number of CD4-lymphocytes, a decline in the number and functional activity of platelets. Intravenous injection of immunoglobulin made in Russia as an adjuvant to combined therapy of HIV-infected subjects contributes to recovery of platelet count and aggregation.

Antigen-Antibody Complex↗
PubMed1993

[Acute kidney failure as a complication of food poisonings].

Literature data and original experience are reviewed on the treatment of alimentary toxoinfections complicated with acute renal failure (ARF). Out of 192 patients prerenal ARF was recorded in 74.5%, renal in 25.5% of the cases. ARF resulted from hemodynamic disturbances, salt and water loss, intoxication. ARF clinical symptoms were poor, the patients developed decompensated metabolic acidosis and hyperazotemia. Pathological and histological evidence is available for 17 patients with "shock kidney". They died of infective toxic shock. The treatment of ARF complicating acute alimentary toxoinfections in 98.9% made a success if implied polyion crystalloid solutions. Hemodialysis was demanded in 1.1% of the cases.

Acute Kidney Injury↗
PubMed1992

[Pathogenesis of anemia in abdominal typhus].

Morphological parameters of the red cells were studied in 121 patients with typhoid-paratyphoid conditions. To obtain objective clinical data the authors studied the effect of LPS S. anatum on the intact red cells of healthy persons. The correlation of morphological disorders in the red cells of the patients and the controls revealed a significant role of intoxication in their origin. The research conducted revealed a relationship between the disorders in the erythrocyte membranes and the development of anemia in the patients.

Adolescent↗
PubMed1991

[Cholera].

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Cholera↗
PubMed1991

[The role of thrombocytes in blood coagulation disorders in infectious pathology].

Platelets play the leading role in circulatory disorders seen in patients with infectious diseases. Endotoxinemia leads to platelet activation which shows up by the transformation of platelet forms from disk-shaped to spheroidal and by changes in aggregation and secretion. The degree of those changes correlates with the disease gravity. Experimental endotoxinemia (in vivo and in vitro experiments) demonstrated the same changes in the morphofunctional properties of platelets together with a possibility of correcting circulatory disorders by blockers of prostaglandin biosynthesis, such as indomethacin++, trental and emoxipine.

Hemorrhage↗
PubMed1991

[Functional state of thrombocytes in Yersinia infection].

As many as 94 patients with yersiniosis were examined for the morphofunctional status of platelets (aggregation, disaggregation, endo-exocytosis and platelet forms). The data indicate that platelet from patients with yersiniosis possess a high ability for aggregation and a low ability for disaggregation. According to the experimental and clinical data, emoxipine can restore disturbed function of human platelets.

Culture Media↗
PubMed1991

[The evaluation of the efficacy of 1st- and 2d-generation oral rehydration solutions in treating patients with acute intestinal infections].

The efficacy of the solutions of oral rehydration salts (ORS) of the first and second generations was estimated in the treatment of patients with acute intestinal infections. 150 patients with food toxicoinfections were examined. Two groups of the patients received the solutions of ORS of the first generation (glucosalan and citroglucosalan) and one group were given the second generation ORS solution based on the rice and salt, manufactured by Galactina (Switzerland). The clinical cases were analyzed. Some biochemical parameters that characterize certain aspects of homeostasis and bioenergetics were explored. The authors emphasize a greater effectiveness of the second generation solutions of ORS producing not only detoxification and rehydration but also serving as a food.

Acute Disease↗