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Biomedical subjects

V V Lebedev

Publications and source records attributed to V V Lebedev.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

[The information value of the EEG in the acute period of subarachnoid hemorrhage as a consequence of rupture of intracranial aneurysms].

The article deals with the results of electroencephalographic (EEG) examination of 65 patients in the acute period of subarachnoid hemorrhage of nontraumatic genesis. The revealed changes in the electrical activity of the brain are compared with the level of disturbed consciousness, the severity of the clinical condition, and the presence of complicated or noncomplicated form of subarachnoid hemorrhage. The main factors determining the degree of disorders of the EEG pattern are discussed. It is shown that the EEG data possess high prognostic significance in determining the outcome of operative treatment of patients in the acute period of the disease.

Acute Disease↗
PubMedDate not supplied

[Digital subtraction angiography in the diagnosis of emergency neurosurgical states].

Digital subtraction angiography (DSA) was used in the examination of 203 patients with various forms of acute diseases and injuries of the brain. The method of the examination is described and its advantages and shortcomings in each type of pathology are revealed. DSA meets the requirements placed upon angiographic examination of patients with acute diseases of the brain and craniocerebral injury and may be used successfully in the diagnosis of emergency neurosurgical conditions.

Adult↗
PubMedDate not supplied

[Prognosis of the outcome of early surgery of rupture of arterial aneurysm of the brain].

The prognostic significance of 10 preoperative and 3 intraoperative factors was studied. The severity of the patient's condition, the EEG changes, an intracranial hematoma, and correspondence of the region of the operation with the zone of the vascular spasm were the most informative preoperative signs of the prognosis of the outcome of early operations. Bleeding during the operation and the duration of the arrest of the blood flow in the main vessel were the most informative intraoperative signs.

Adolescent↗
PubMedDate not supplied

[Function of the cardiovascular system and treatment outcomes in arterial brain aneurysms in the hemorrhagic period].

Study of the ECG and central hemodynamics and the results of mathematical analysis of the heart rhythm in patients with rupture of arterial aneurysms in the pre- and postoperative period showed that the values of cardiovascular activity are prognostic signs of the outcome of surgical and nonoperative treatment. Postponement of operation on patients with arterial hypertension for 1-3 days from the onset of the disease may be fatal. Correction of increased systolic pressure and high cardiac output after the operation is inadmissible because they are favourable responses of the organism to the operative trauma. Moderate activation of the sympathetic and parasympathetic nervous system on the eve of the operation has a favourable effect on its outcome.

Adult↗
PubMedDate not supplied

[Surgical treatment of intracranial hematoma in the acute period of rupture of cerebral aneurysm].

The authors analyse the results of surgical treatment of intracranial hematomas in the acute period of ruptures of arterial aneurysms in 38 patients. The surgical tactics and volume of surgical intervention are determined according to the rate of the clinical manifestations of the hematoma and the severity of the patients' condition. Rupture of the hematoma into the ventricles of the brain and a hematoma more than 60 cm3 in volume are of unfavourable prognostic significance in ruptures of aneurysms attended by the formation of a hematoma. A vascular spasm in the presence of a hematoma is not a dominant factor determining the outcome of the operation.

Acute Disease↗
PubMedDate not supplied

[Testing of visual function by the evoked potential method before and after surgical treatment of optico-chiasmal arachnoiditis].

Dynamics of changes of visual evoked potentials recorded in patients with optico-chiasmatic arachnoiditis in response to a flash of light were revealed during restoration of visual function in the postoperative period. In improvement of visual functions no changes were found of evoked potentials recorded in a chess pattern in the immediate postoperative period.

Arachnoiditis↗
PubMedDate not supplied

[Surgical treatment of cerebral aneurysms complicated by vasospasm in the acute period].

The results of clipping of an aneurysm in the acute period of subarachnoid hemorrhage are analysed. It is shown that vascular spasm is an increased risk factor if it involves up to 3-4 and more arterial basal segments and is attended by marked general cerebral and focal neurological symptomatology and gross disorders of cerebral function. Such vascular spasm is unfavourable from the standpoint of prognosis in determining the outcomes of the operation.

Acute Disease↗
PubMedDate not supplied

[Effect of temporary interruption of blood flow through the major intracranial vessels on the outcome of surgical treatment of arterial aneurysms].

During operations for clipping an aneurysm, the blood flow along the artery supplying this aneurysm was temporarily arrested in some patients to prevent intraoperative hemorrhage. It has been proved that the arrest of blood flow along the main vessel for more than 20 minutes during an operation in the acute period of subarachnoidal hemorrhage, particularly in the presence of a vascular spasm, aggravates the course of the postoperative period and is conducive to the lethal outcome.

Acute Disease↗
PubMedDate not supplied

[Various characteristics of growth kinetics and exohydrolase synthesis in Aspergillus foetidus and Zygofabospora marxiana].

The kinetics of growth and synthesis of exohydrolases (polygalacturonases and proteinases) were studied in Aspergillus foetidus and Zygofabospora marxiana. The processes of growth and synthesis of polygalacturonases were found to be shifted in time. Endopolymethylgalacturonase of the micromycete and endopolygalacturonase of the yeast are not accumulated in the cells, but are mainly secreted into the growth medium. The maximal value of polygalacturonase bound to the cell coincides with the maximal rate of synthesis of the enzyme secreted into the medium and with the maximal level of cell-bound alkaline and acid proteinases. The activity of alkaline proteinase is not found in the growth medium of the cultures, and only traces of acid proteinase were detected. It is possible that proteinase are involved in processing of endopolygalacturonases.

Ascomycota↗
PubMedDate not supplied

[Results of surgical treatment of intracranial arterial aneurysms].

The results of surgery for arterial aneurysms of the brain are analysed. It was found that the severity of the patient's condition rather than the time of the operation had an effect on the outcome of surgery. The severity of the patient's condition and the outcome of the operation were determined first of all by the presence of the intracranial hematoma, cerebrovascular spasm, escape of blood into the ventricles of the brain, and the degree of manifestation of subarachnoid hemorrhage. The advantage of early operations for the prevention of repeated ruptures of the aneurysm is pointed out.

Adolescent↗
PubMedDate not supplied

[Analysis of causes of death in the acute period of ruptured intracranial aneurysms].

The causes of death of 80 patients with ruptured aneurysms of the brain are analysed; 37 of them underwent operation. Intracranial hypertension with edema and dislocation of the brain was the main cause of death both of patients who were operated on and of those not subjected to surgery. Intensive subarachnoid hemorrhage, vascular spasm, intracranial hematoma, and the escape of blood into the ventricles of the brain lead to the development of intracranial hematoma. Besides, in patients who were operated on, edema of the brain developed as a consequence of its injury during manipulations and clipping of a large vessel. In some cases, death of patients with ruptured intracranial aneurysms was due to extracranial factors.

Adolescent↗
PubMedDate not supplied

[Tentoriotomy in severe craniocerebral injuries].

The results of surgical treatment of 110 patients with severe craniocerebral trauma and acute midbrain dislocation syndrome are discussed. The principal operation for removal of the injured site (hematoma or focus of brain crushing) was supplemented in all cases by mildly injurious tentoriotomy. As a result, lethality in the group of patients subjected to tentoriotomy decreased. Criteria (clinical, electrophysiological, and angiographic) are characterized on the basis of which the indications for tentoriotomy in craniocerebral trauma are determined.

Adult↗