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Biomedical subjects

V V Kozlov

Publications and source records attributed to V V Kozlov.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Diagnosis and surgical treatment of relative valvular insufficiency of deep veins of the lower limbs].

The experimental and clinical findings obtained by the authors have evidenced the rationale of using an autovein or large femoral fascia for application of a cuff. While using synthetic materials, some cases of venous thrombosis under a cuff were observed. Late results of the operation during 2-5 years were followed up in 25 patients, 13 of them had crural ulcers. No varicosity and ulcers were noted in outpatient examination.

Animals↗
PubMedDate not supplied

[Urodynamic studies in the diagnosis of infravesical obstruction in men].

The authors have performed urodynamic investigations pressure-flow in 39 males (mean age 57.9 +/- 1.8 years) to detect infravesical obstruction. Interpretation of the findings rested upon Abrams-Griffits index (AGI) derived by the formula AGI = PdetQmax - 2xQmax, where Qmax is the maximal speed of urine flow and PdetQmax is detrusor pressure when the maximal urine flow is reached. Definite conclusion on the presence or absence of infravesical obstruction was feasible for 21(53.8%) of 39 examinees, was not possible for 18(46.2%) patients. Statistical processing yielded non-linear relationship between PdetQmax and Qmax (cubic parabola) requiring correction for AGI (coefficient K calculated according to the formula K = 58.7 - 0.00554x(Qmax)3). This correction for nonlinearity K allowed classification of 11 out of 18 patients who were initially indefinite. By standard AGI technique, the uncertainty zone made up 46.2% while correction for nonlinearity reduced this zone to 18.0% (p < 0.008). Thus, the account for nonlinearity of the relationship between PdetQmax and Qmax may contribute to a rise in diagnostic value of urodynamic investigations.

Humans↗
PubMedDate not supplied

[Clinical significance of the determination of R-proteins in the ejaculate of patients with chronic prostatitis].

Products of cell receptor (R-proteins) catabolic lysis were measured in ejaculate of 121 patients with chronic prostatitis and 15 healthy males. R-protein levels were higher in the patients (U = 172.5; p = 0.047). When immunological indices of the ejaculate (IgA, sIgA, IgG, IgM, interleukin-8) were measured, it was found that in patients with chronic prostatitis there is a positive correlation between concentration of interleukin-8 and content of R-proteins (r = 0.43; p = 0.028). Positive correlation also exists between R-protein content and prostate volume (r = 0.24; p = 0.034) while negative one--between R-proteins concentration and size of the hypoechogenic sites in the prostate (r = -0.25; p = 0.039), between R-proteins in the ejaculate and serum level of fibrinogen B (r = -0.25; p = 0.021). It is inferred that elevation of ejaculate R-protein level occurs in alteration of the prostate. The test for R-proteins in ejaculate can be helpful in detection of early stages of chronic prostatitis.

Adolescent↗
PubMedDate not supplied

[Diagnostic role of interleukin-8 determination in chronic prostatitis].

Measurements were made of interleukine-8 (IL-8) levels in ejaculate, prostatic secretion, blood serum of 60 patients with latent chronic prostatitis (CP). These levels were higher in CP patients than in healthy subjects. A rise in concentrations of IL-8 in prostatic secretion and ejaculate correlates with other inflammation markers. This may indicate the degree of CP activity. No relationship between IL-8 levels in ejaculate and prostatic secretion, and large dispersion of this marker allow using this criterion for diagnosis in combination with other indices of local immunity.

Adolescent↗
PubMedDate not supplied

[Informative value of immunologic analysis of blood and ejaculate in diagnosing chronic prostatitis].

Ejaculate and blood serum from 40 patients with chronic prostatitis were studied immunologically, IgG, IgA, sIgA, IgM concentrations in ejaculate may be greatly influenced by multicomponent composition of ejaculate. This means that it is impossible to diagnose chronic prostatitis only by changes of immunoglobulin concentrations in ejaculate. Data on IgA, sIgA concentrations plus on leukocyte count in ejaculate give more information for precise diagnosis of chronic prostatitis.

Adolescent↗
PubMedDate not supplied

[Prognostic implication of morphometric stromal parameters of renal pelvis and ureteral transitional cell carcinomas].

To evaluate prognostic value of morphometric studies of the stroma of transitional cell carcinomas of the renal pelvis and ureter, we studied retrospectively the data of primary examination and follow-up of 75 patients (49 males, 65% and 26 females, 35%; mean age 61.9 +/- 1.2 years) given radical surgical treatment for cancer of the renal pelvis and ureter. Five-year survival in the absence of tumor progression was 23%. Morphological examination diagnosed transitional cell carcinoma with invasion pT1, pT2, pT3 and pT4 in 3(4%), 15(20%), 47(63%) and 10(13%) cases and differentiation degree G1, G2, G3 in 31(41%), 15(20%) and 29(39%) cases, respectively. In addition to the standard morphological examination of the tumor, we made morphometry of stromal and tumor area, analysed composition and count of stromal effector cells (lymphocytes, eosinophilic and neutrophilic leukocytes, macrophages, mast and plasmic cells), the degree of stromal vascularization. Prognostic value of the above parameters was estimated according to significance of their correlation with postoperative survival of the patients. The survival correlated with the depth of cancer invasion (p = 0.005) and differentiation of tumor tissue (p = 0.006), high cell infiltration of tumor stroma is prognostically unfavourable (R2 = 0.03; F = 3.41; p = 0.069) as well as weak presentation of stromal component of the tumor (p = 0.056). The lowest survival was observed in patients with cancer of the renal pelvis and ureter with a great number of mast cells (p = 0.056), macrophages (p = 0.037) and neutrophils (p = 0.029) in the tumor stroma. According to the results of multiple regression analysis (R2 = 0.08; F = 5.42; p = 0.024), five-year postoperative survival most closely correlated with cancer invasion depth (p < 0.001), degree of tumor cells differentiation (p < 0.001) and number of macrophages infiltrating tumor stroma (p < 0.001). Significance of survival prognosis for patients with cancer of renal pelvis and ureter can be raised by estimation of mean number of free stromal cells and expression of stromal component.

Carcinoma, Transitional Cell↗
PubMedDate not supplied

[Endoscopic operations in invasive cancer of the urinary bladder].

Long-term results of conservative treatment of 153 patients with invasive cancer of the urinary bladder were studied retrospectively. The patients had stage T2 (n=121, 79.1%), T3 (n=26, 17%), T4 (n=6, 3.9%). All the patients had transitional cell cancer. GI, G2 and G3 tumors were registered in 104 (68%), 35 (24%) and 12 (8%) cases, respectively. 88 (57.5%) patients received combined treatment, 65 (42.5%) patients--only surgery. In the patients with a small invasive tumor of the urinary bladder subjected to surgery alone (TUR-vaporization), overall 5-year survival was 70.4%. In patients with advanced cancer of the urinary bladder who had received curative radiotherapy in case of superficial residual tumor had TUR-vaporization of the urinary bladder overall 5-year survival was 76.5%. In patients exposed to large-fraction (TFD 20-25 Gy) preoperative radiotherapy followed by TUR-vaporization, survival at this moment was 84.6%. Three-year overall and recurrence-free survival at stage T2 was 97.5 and 47.4%, respectively; at stage T3 and T4 overall 3-year survival was 57.1 and 26.6%, respectively. Thus, the conclusion is that transurethral electrosurgery in conservative therapy of patients with invasive cancer of the urinary bladder is a promising approach.

Adult↗
PubMedDate not supplied

[Enterosorption in experimental acute kidney failure].

The paper provides the results of 32 experiments on 22 mongrel male dogs with a view to measuring creatinine levels in the lumen of various intestinal segments before and after bilateral nephrectomy and evaluating the effects the enterosorbent brand SKN administered into isolated portions of the intestinal tube on alteration of intraluminal concentrations of creatinine, serum creatinine, and "middle-sized" molecules. Four parts of the intestine were identified: (1) proximal; (2) middle and (3) distal portions of the small intestine, and (4) the large intestine up to the anal sphincter. Two days following bilateral nephrectomy, creatinine levels were increased in the proximal, middle, distal portions of the small bowel and in the large bowel by 18, 11, 5, and 1.4 times, respectively, as compared to the baseline creatinine concentration in the intestinal parts mentioned. The administration of the enterosorbent into the different intestinal parts revealed that with its 6-hour exposure, the most potent effect (lower concentrations of creatinine and "middle-sized" molecules in serum) was observed in the proximal portions of the small bowel. This phenomenon is likely to be attributable to greater vascularization and the maximal creatinine and "middle-sized" molecule concentration in these intestinal portions. With this, it was shown that the higher baseline concentrations of serum creatinine and "middle-sized" molecules were, the more actively they absorbed on the charcoal enterosorbent brand SKN in the intestine.

Acute Kidney Injury↗
PubMedDate not supplied

[Comparative evaluation of the selectivity of proteinuria in various types of diabetes mellitus].

The results are presented on the comparative studies of proteinuria selectivity in 62 patients with diabetes mellitus depending on the age, diabetes type, duration and severity of the disease. In the absence of clinical manifestations of diabetic glomerulosclerosis affected proteinuria selectivity indices were found only in patients with insulin-depending (the juvenile type) diabetes. The study of the data obtained has shown a close correlation between proteinuria selectivity and severity of diabetic glomerulosclerosis clinical manifestation.

Adolescent↗
PubMedDate not supplied

[Effect of trental on indices kidney function in diabetes mellitus].

Effect of trental on some renal function parameters was studied in 11 patients with diabetes mellitus, 7 of these patients had clinical signs of diabetic nephropathy. Trental was administered by intravenous drip in a dose of 300 mg daily during 3 weeks. Marked improvement of renal function under the effect of trental was recorded: glomerular filtration increased, proteinuria diminished, and the level of glycemia reduced. No side effects of trental treatment were observed. It is suggested that trental be used in comprehensive treatment of diabetes mellitus patients

Adult↗