[Bronchoalveolar cancer].
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Biomedical subjects
Publications and source records attributed to V V Kozlov.
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A method of random sampling was applied to 10 CRI patients to analyze the results of 24 hemodialyses with acetate solution for dialysis (35 mmol/l) and 34 hemodialyses with bicarbonate solution for dialysis (35 mmol/l). Significant reduction of complications like headache, nausea, vomiting, tachycardia, dyspnea, extrasystole was observed in bicarbonate dialysis. The concentration of mean molecular uremic toxins was decreased from 5.75 +/- 0.84 mmol/l in acetate dialysis up to 2.63 +/- 0.21 mmol/l in bicarbonate dialysis. The content of intracellular potassium returned to normal. The concentration of serum cholesterol was decreased from 5.6 +/- 0.4 up to 4.8 +/- 0.2 mmol/l. These data indicated a favorable effect of bicarbonate dialysis on intracellular metabolism. Preliminary data did not confirm the normalizing effect of bicarbonate dialysis on the development of uremic osteopathy.
Morphological, immunological and biochemical aspects of pathogenesis and manifestation of the nephrotic syndrome in patients with chronic glomerulonephritis were considered on the basis of the authors' result and literature data. High clinical importance of the lymphocyte stimulation index for patients' follow-up was emphasized. 131I-albumin metabolism was studied in 105 patients phenotyping of nephrotic hyperlipoproteinemia was done in 28. The results obtained suggested the relationship of protein, lipid and carbohydrate metabolic derangements with severity of the nephrotic syndrome. Possible causation of the above phenomena was discussed.
Certain general problems on foundation of the hormonal regulation mechanisms during the prenatal and early postnatal ontogenesis are discussed basing on the authors' own results and on the literature data. They concern development of the hypophysis and peripheral target-glands in immaturely-bone Mammalia and fowls. The data on foundation of the endocrine glands functional activity are compared in rats and hens. The notion on a relative autonomous hormonal function of the peripheral endocrine glands at early stages of ontogenesis is motivated.
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A state of 131-albumin metabolism has been investigated in 70 patients with some diffuse renal disease. In patients with chronic renal insufficiency an intravascular albumin mass was in the normal limits, while an albumin concentration was decreased because of an anemia. A depression of albumin catabolism has been noticed in azotemia as well as in albuminuria. A conclusion has been made that serum albumin concentration cannot be a reliable index of the state of protein metabolism in patients with chronic renal failure.
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Globin synthesis rate (GSR) by nucleated erythroid cells was investigated in 40 patients suffering from chronic glomerulonephritis, in 24 subjects with other renal diseases and in 8 healthy controls. GSR was reduced in nephrogenic anemia; moreover, this reduction took place in a few patients without anemia. The correlation between GSR and some characteristics of erythropoiesis was examined. The supression of GSR is probably one of the important causes of nephrogenic anemia.
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