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Biomedical subjects

V V Filatov

Publications and source records attributed to V V Filatov.

At least 19 recordsLinked to original sources
PubMed2002

[Urgent problems of medical aid in infectious endocarditis].

The authors analyze the incidence of infectious endocarditis (IE), the influence of diagnostic time on the lethality, the significance of surgical treatment. The main ways of further improvement of IE patient therapy are defined. They include the training of medical staff, centralization of the patients in the military medical institutions of the center by transfer from the districts after making the diagnosis in order to conduct the adequate medicamentous and appropriate surgical treatment.

Anti-Bacterial Agents↗
PubMed1997

Effects of 50% ethanol and mechanical epithelial debridement on corneal structure before and after excimer photorefractive keratectomy.

PURPOSE: The corneal epithelium is generally removed before photoablation in photorefractive keratectomy (PRK) because laser transepithelial PRK may result in surface irregularity caused by variability in epithelial thickness and differing ablation rates between epithelium and stroma. We compared the effects of mechanical deepithelialization with chemical epithelial removal by using 50% ethanol on the corneal structure. METHODS: Fourteen rabbits underwent corneal deepithelialization by using a blade in the left eye and 24 h later in the right eye. Another 14 rabbits underwent corneal deepithelialization by using 50% ethanol solution. Half of the eyes treated with each technique underwent PRK after deepithelialization. Pachymetry was performed before and after each procedure on right eyes. Keratocyte and neutrophil densities were assessed by light microscopy. RESULTS: Among non-laser-treatment groups, eyes that underwent mechanical deepithelialization had decreased corneal thickness (p = 0.001), increased keratocyte densities (p = 0.03), and no significant difference in neutrophil densities (p = 0.91) compared with chemically treated eyes 24 h after surgery. Among laser-treatment groups, eyes that underwent mechanical epithelial removal had increased keratocyte densities (p = 0.001), decreased corneal thickness (p = 0.03), and increased neutrophil densities (p = 0.03) 24 h after surgery compared with chemically treated eyes. CONCLUSION: Deepithelialization with 50% ethanol causes more keratocyte loss with perhaps more corneal edema, but less stromal influx of neutrophils, than does a mechanical technique 24 h after PRK in a rabbit model. Corneal deepithelialization with dilute ethanol may be a viable option in PRK. However, further investigation into the safety of this technique is warranted before it can be widely applied clinically.

Administration, Topical↗
PubMed1982

[Carcinoid tumor of the mediastinum].

A carcinoid tumor of the mediastinum in a man of 58, incidentally detected at a roentgenological examination is described. Its histological structure was identical with that of carcinoids of other localization. The tumor cells contained argyrophilic granules. The patient died 41/2 years after the operation in the presence of extensive lymphogenic and hematogenic metastases. The authors believe that signs such as cellular and nuclear polymorphism, outgrowth of the tumor cells into the capsule, lymph vessels detectable even in limited area should be considered as criteria of malignancy of the neoplasma and the basis for prescription of radiation and chemotherapy.

Carcinoid Tumor↗
PubMedDate not supplied

[Clinical assessment of infrasonic phonophoresis efficacy in the treatment of bacterial keratitis].

Therapeutic efficacy of infrasonic phonophoresis is studied in 30 patients with bacterial keratitis. Control group consisted of 87 patients with the same diagnosis. Clinical studies included comparative evaluation of the therapeutic efficacy of infrasonic phonophoresis and traditional local instillations of the same drugs. Before treatment, visual acuity was the same in both groups, while after regression of inflammation after treatment it was 0.13 higher in the phonophoresis group. Results of clinical studies indicate a higher efficacy of infrasonic therapy of patients with keratitis. The duration of therapy was decreased, number of bed-days decreased, and visual acuity after treatment improved.

Eye Infections, Bacterial↗
PubMedDate not supplied

[Experimental study of infrasonic phonophoresis].

A new method of drug administration, infrared phonophoresis, was experimentally studied. The method has no analogs in the world. The study was carried out on 20 Chinchilla rabbits. Water applications impregnated with equal volumes of the radiopharmaceutical (RP) were placed into the conjunctival cavities of both eyes. The right eye was control and the left was treated by infrasound (experiment). The information was recorded in live animals after removal of the application and thorough washing of the conjunctival cavity immediately, 30 min, and 1 h after infrasound phonophoresis session. Radioactivity measurements at all terms indicate its stable increase in the experimental eye and a progressive decrease in the control eye. Hence, infrasound promoted long accumulation of the RP in the eye at anterior route of the drug delivery without preliminary injection of the drug into ocular vessels.

Animals↗