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Biomedical subjects

V T Ivashkin

Publications and source records attributed to V T Ivashkin.

At least 19 recordsLinked to original sources
PubMed2006

[Methods of early diagnostics of hepatic fibrosis and cirrhosis].

The article covers the functional and clinical importance of hepatic fibrosis. Contemporary principles of invasive and non-invasive diagnostics of fibrotic changes are described. The article deals with the main types of fibrosis, chronic hepatic diseases in which they develop, and the most wide-spread systems of semiquantitative evaluation of fibrotic process' morphologic signs.

Biopsy↗
PubMed2006

[The diagnostic significance of laser 13C-urea breath test in various Helicobacter pylori-associated diseases].

The authors present the results of laser-based 13C-urea breath test (13C-UBT) application in diagnostics of Helicobacter pylori-associated diseases (chronic gastritis, duodenitis, and peptic ulcer). 13C-UBT data distribution before and after eradication therapy, as well as age distribution, were obtained. Correlations between the nosological forms and the rate of contamination were established.

Adult↗
PubMed2006

[Treatment of patients with essential hypertension using bifunctional 24-hour blood pressure and ECG monitoring].

The results of 24-hour blood pressure monitoring (BPM) help to divide patients into therapeutic groups according to the leading hemodynamic mechanism offorming essential arterial hypertension (EAH). In patients with a mean day heart rate of > or =73 bpm antihypertensive therapy should begin with beta1-adrenoblockers when not contraindicated. In patients with a mean day heart rate of < or =73 bpm antihypertensive therapy may be started with preparations of other pharmaceutical groups. In this study, Plendil or Concor was administered as a chronotherapy; later their combination was used, and diuretics or ACE inhibitors were added when necessary. At any stage of the study, starting from the second week of therapy, if blood pressure (BP) was normal and there were ischemic episodes according to matched 24-hour BPM and ECG, Cardiket and, when not contraindicated, Aspirin, were added. The offered algorithm of choice of therapy made it possible to achieve a good antihypertensive effect in 84% of patients and a satisfactory effect in 7% of patients, which was accompanied by a tendency towards the shortening of total ischemia duration and lowering the frequency of myocardial hypokinesia. The effect of the therapy was poor only in 9% of patients, 2% of whom one left the study due to adverse reactions before BP was normalized. BP was normalized on the 8th week of treatment in 75% of patients. It is appropriate to include matched 24-hour BPM and ECG in the follow-up of patients with EAH and coronary artery disease upon discharge under the conditions of routine physical load. According to 24-hour BPM, mean day heart rate and total length of ischemia grow during this period due to an increase in physical and emotional load, which requires correction of the therapy.

Adult↗
PubMed2006

[Apoptosis of peripheral blood mononuclears and evaluation of the effectiveness of antiviral therapy of chronic C hepatitis].

The effects of combined antiviral therapy on the apoptosis of peripheral blood mononuclears (PBM) were investigated in 54 patients with chronic hepatitis C (CHC), including patients with chronic viral-and-alcohol hepatitis (CVAH). Simultaneously, serum concentrations of cytokines (tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and interleukins 10 and 12) using flow cytofluorimetry were taken. The results demonstrate an increase in the intensity of PBM apoptosis in patients with CHC and CVAH vs. controls; there was a tendency of lesser apoptosis intensity in the CVAH subgroup. In both groups IFN-gamma and TNF-alpha concentrations were increased, and there was a direct correlation between the level of apoptosis and TNF-alpha concentration. The study found an increase in the intensity of apoptosis in CHC patients with primary virological response to antiviral therapy with IFN-alpha and riboflavin, which can be considered an additional prognostic factor of the effectiveness of treatment.

Adolescent↗
PubMed2005

[Nitric oxide and cardiac failure].

AIM: To study the synthesis of nitric oxide II (NO) in patients with acute myocardial infarction (AMI) and patients with postinfarction cardiosclerosis (PICS) with chronic cardiac failure (CCF). MATERIAL AND METHODS: The study included 125 patients: 35 patients with Q-wave AMI and 90 PICS patients. AMI patients were examined clinically, device and laboratory tests were made to measure NO metabolites in the urine, plasma, culture medium of peripheral blood mononuclear cells on MI day 1 and 21, iNOS was estimated in mononuclear cells of peripheral blood on MI days 1, 2, 7, 14 and 21. PICS patients examination incorporated assays for NO metabolites in 24-h urine and plasma, in blood lymphocytes on MI day 1, 14 and 28.2 days before NO tests, all nutritional nitrates and nitrites were excluded from the diet. Control group consisted of 15 nonsmokers aged 33 to 53 years (mean age 43.7 +/- 9.3 years). The level of NO metabolites in the urine was 49.7 mcM, in plasma--19.7 mcM, in lymphocyte culture--28.8 mcM. RESULTS: By urinary nitrites/nitrates all the MI examinees were divided into three subgroups: with low, moderate and high levels content of nitrites and nitrates (subgroups 1, 2 and 3, respectively). The correlation analysis has established significant correlations between NO metabolites in urine and plasma in the first MI hours and the data on the clinical status, device characteristics of myocardial lesion extention and prognosis of the disease. The most severe MI course and PICS was seen in subgroup 1, of moderate severity--in subgroup 3, a favourable course--in subgroup 2. CONCLUSION: Assay for nitrites and nitrates in the urine and plasma is necessary for selection of pathogenetically validated prescription of nitrates to AMI and PICS patients.

Adult↗
PubMed2005

[Current methods of early diagnosis of hepatic fibrosis].

The article covers the functional and clinical significance of hepatic fibrosis. Contemporary principles of invasive and non-invasive methods of diagnostics of fibrotic alterations are described. The article also covers the main forms of fibrosis, chronic hepatic diseases in which they are found, and the most wide-spread systems of half-quantitative evaluation of morphological signs of the fibrotic process.

Early Diagnosis↗
PubMed2004

[Characteristics of nitric oxide synthesis in patients with chronic cardiac failure].

Synthesis of nitric oxide (NO) in patients with chronic cardiac failure (CCF) is specified. It is shown that CCF runs differently in patients with different NO production. Significant correlations exist between content of nitrites/nitrates (end NO metabolites) in 24 h urine, plasm of CCF patients and principal clinical, laboratory and device tests results in CCF. Basal levels and accumulation of nitrites/nitrates in 24 h urine and plasm of CCF patients are of prognostic importance.

Aged↗
PubMed2002

[Cytokine system in patients with chronic hepatitis C during treatment with interferon-alfa].

AIM: To study changes in serum levels of interleukine-1 beta (IL-1b), IL-6, TNF-alpha (TNFa), HM-HMF and TFR-1 beta (TFR-1b), expression of surface antigens CD14 and CD95 on blood monocytes from patients with chronic hepatitis C (CHC) treated with interferon-alpha (INFa). MATERIAL AND METHODS: Examinations covered 25 CHC patients and 25 healthy controls. Concentrations of proinflammatory cytokines and growth factors in blood serum were measured with ELISA (kits by "R&D systems", USA). CD14 and CD95 antigen expression on monocytes of venous blood were studied using flow cytoflowmeter (Partes, USA) before and after a 12-week course of INFa. RESULTS: Before INFa treatment CHC patients had significantly elevated serum concentrations of TNFa, HM-KSF and TFR-1b. Coexpression of antigens CD14+ and CD95+ was found on 61% of blood monocytes. Three-month INFa treatment lowered levels of TNFa, GM-KSF and CD95+ expression on monocytes as well as TFR-1b concentration in the serum which correlated with a positive trend in the standard clinicolaboratory and virusological indices in the examinees. CONCLUSION: Changes in serum indices of proinflammatory cytokines and growth factors, in expression of CD95 on blood monocytes from CHC patients treated with INFa show an important role of cytokines system activation and mechanisms of programmed cell death in pathogenesis of chronic HCV infection.

Adolescent↗
PubMed2002

[Management of patients with raised and non-raised ST acute coronary syndrome].

Unstable angina pectoris has been regarded for many years as an intermediate state between chronic stable angina and acute myocardial infarction. Recently it has been found that unstable angina pectoris and myocardial infarction are consequences of the same pathophysiological process--rupture or erosion of atherosclerotic plaque and joining thrombosis and embolism of distal vessels. It would be valid to use the term "acute coronary syndrome" (ACS) as a provisional diagnosis. Among AC8 patients there are patients with and without ST segment elevation. This dictates therapeutic policy and predicts the patients' survival. Two clinical cases illustrate the validity of the above division and effectiveness of adequate policy of the above patients therapy.

Anti-Inflammatory Agents, Non-Steroidal↗