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Biomedical subjects

V Singh

Publications and source records attributed to V Singh.

At least 325 records · Page 18Linked to original sources
PubMed1988

Adenosine deaminase activity in leprosy (a preliminary study).

Adenosine deaminase (ADA) activity was studied in 25 patients having different types of leprosy and 25 healthy volunteer as control. There was definite rise of ADA activity in BL (72.9 +/- 6.85), LL (56.7 +/- 3.35) and BT (39.1 +/- 8.28) which was statistically significant when compared to ADA activity in healthy control (9.7 +/- 0.53).

Adenosine Deaminase↗
PubMed1987

Tuberculous meningitis: role of CT in management and prognosis.

Serial computed tomographic scans were performed during the course of tuberculous meningitis in 25 patients aged 1-70 years. Hydrocephalus rarely occurred without other abnormalities. Marked ventricular enlargement was associated with extensive basal enhancement. Basal meningeal enhancement was not a good indicator of the clinical state although marked enhancement was a risk factor for the development of basal ganglia infarction. Infarcts were much more common in children than in adults and were sometimes asymptomatic. Radiological abnormalities sometimes developed during treatment and often did not resolve completely. Many patients had severe residual neurological problems.

Adolescent↗
PubMed1987

Thoracic pressure and nasal patency.

Maximum nasal flow rate in the right and left nostrils was simultaneously determined during expiration with the help of two flowmeters in 10 healthy subjects in different postures and in two patients, one with Horner's syndrome and the other with facial palsy. It was found that pressure on the hemithorax from any surface (i.e., lateral, anterior, posterior, or superior) leads to reduced patency of the ipsilateral nostril but increased patency of the nostril on the opposite site. In the patient with Horner's syndrome, the nostril on the affected side remained blocked even on compression of the opposite hemithorax, and in the one with facial nerve palsy, the nostril on the affected side remained patent despite compression of the hemithorax on that side. The findings suggest that compression of hemithorax leads to changes in the congestion of the nasal mucosa that may be mediated through autonomic nerves.

Autonomic Nervous System↗
PubMed1987

Effect of respiratory exercises on asthma. The Pink City lung exerciser.

Twelve subjects with mild asthmatic episodes in the form of nocturnal precipitation were studied. A two-week schedule of placebo administration, pranayamic breathing exercises using a Pink City lung exerciser alone, and exercises using the lung exerciser with hot, humid air were performed. Five of the 12 asthmatics showed highly significant increases in peak expiratory flow rate (PEFR) with the lung exerciser alone, while eight of the 12 cases showed highly significant increases in PEFR with exercise using hot, humid air. The frequency of nocturnal wheezing also declined. It can be inferred that slow breathing alone and in combination with hot, humid air has a nonspecific bronchoprotective or bronchorelaxing effect.

Adolescent↗
PubMed1987

Structure-anticonvulsant activity relationships of cannabidiol analogs.

Cannabidiol (CBD) exhibits anticonvulsant activity in experimental animals and in man. As part of a structure-activity study, analogs were prepared wherein the terpene unit, the aryl unit, and/or the side chain were modified. Thus, several pinenyl and carenyl derivatives, aryl ethers and acetates, and a variety of 1",1"-dialkylhexyl and 1",1"-dialkylheptyl analogs were synthesized. The compounds were evaluated for anti-convulsant activity in seizure susceptible (AGS) rats and for neurotoxicity in the rat rotorod (ROT) test. Comparisons of stereoisomers of CBD and several analogs revealed a general lack of stereoselectivity for anticonvulsant and other CNS properties of this class of compounds.

Animals↗
PubMed1987

Immunospecificity and affinity studies on the monoclonal anti-gonadotropin releasing hormone (GnRH) antibodies: monoclonals produced by azotized GnRH preferentially recognise to native GnRH.

Monoclonal anti-GnRH(MoAb) antibodies generated by using azo-GnRH-TT conjugate were purified by affinity chromatography using azo-GnRH-BSA-Sepharose 4B column. The affinity column bound (A-MoAb) and unbound (U-MoAb) fractions were tested for immunoreactivity towards GnRH(NH2), azo-GnRH(NH2) and GnRH free acid and its fragments of sequence 4-6, 7-10 and 4-10. Both fractions reacted best with native GnRH and about 20 times less to azo-GnRH. The cross-reactivity with other GnRH(OH) fragments and affinity characteristics of A-MoAb, and U-MoAb was comparable with those of MoAb. The immunoreactivity of both the fractions was regained when C-terminus of GnRH free acid was blocked by MDP-Lys, Lys or Ala-Ala-Thr-Lys-Pro-Arg-OH indicating the importance of C-terminus amide in the recognition ability of antibodies.

Amino Acid Sequence↗
PubMed1986

Evaluation of E and EAC rosette-forming cells in patients with thermal injuries.

Thermal injuries lead to changes in both the cell-mediated and humoral responses of the patient. This study was undertaken to assess these responses in the post-burn period and also to see if bacterial infection altered these responses. It has been concluded that alterations in the cell-mediated and humoral immune responses following thermal injuries are altered by infection and consequently are also important in the healing process.

Bacterial Infections↗