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Biomedical subjects

V Schulz

Publications and source records attributed to V Schulz.

At least 127 records · Page 7Linked to original sources
PubMed1980

[Autoradiographic distribution of 14C after administering tracer-marked nitroprusside, cyanide and thiocyanate to pregnant mice and rats (author's transl)].

Doses of ca. 2--3 mg/kg of nitroprusside, cyanide and thiocyanate, tracer-marked with 14C, were applied i.v. to pregnant mice and rats. Autoradiograms of the whole animal were taken 1 min, 10 min and 60 min after administration. After administering nitroprusside two phases of the tracer pattern could be distinguished: the phase of removal of the cyanide poisoning with tracer-markings predominant in the liver and the lungs, followed by the phase of thiocyanate excretion, with tracer-markings predominantly in the stomach and urinary system. Tracer-markings in the foetuses were observed during the thiocyanate phase, but not during the cyanide phase. The therapeutic consequences are discussed.

Animals↗
PubMed1979

Counteraction of cyanide poisoning by thiosulphate when administering sodium nitroprusside as a hypotensive treatment.

A 42-year old patient received a continuous infusion of sodium nitroprusside (SNP) at a dosage rate of 600 microgram/min for approximately four days. On the third day of treatment a dangerous high level of cyanide was measured in the blood. When an additional continuous infusion of sodium thiosulphate at five times the molar concentration of the SNP was given, this cyanide level dropped over a period of 7h to one-seventh of its initial value. The thiosulphate did not reduce the effectiveness of the SNP in lowering the blood pressure.

Adult↗
PubMed1979

Kinetics of elimination of thiocyanate in 7 healthy subjects and in 8 subjects with renal failure.

The concentration of thiocyanate in the serum of eight test subjects with renal failure and seven healthy control subjects was measured, as it declined with time, after oral doses of thiocyanate or i.v. injections of nitroprusside had been administered. Additional measurements were taken, on the healthy subjects only, of the concentrations of thiocyanate in the urine, and also of the influence of an increased chloride intake on the rate of elimination of thiocyanate. For the healthy subjects an elimination half-life of between one and five days (mean c. 3 days) was found. Increasing the chloride elimination rate to approximately twice normal did not significantly speed up the rate of thiocyanate elimination. The amounts of thiocyanate which had been administered as doses reappeared almost exclusively in the urine. For the subjects with renal failure, the elimination half-life had a mean value of approximately nine days. The elimination constants were found to be proportional to the creatinine-clearance rates. The ke value at a creatinine-clearance of zero ml/min was approximately 15% of the ke value at a creatinine-clearance rate of 120 ml/min. The distribution volumes for thiocyanate were greater for the patients with renal failure than for the healthy subjects. The conclusions for therapies using nitroprusside are discussed.

Adult↗
PubMed1979

[Early diagnosis of small airways disease in young smokers (author's transl)].

Investigations during the past years have established that determinations of closing volume, flow-volume curves and frequency-dependent compliance are capable of detecting pathological changes in the bronchial system at a time when the customary lung function tests (FEV1.0 resistance as measured by bodyplethysmography) are still normal. These observations have been made use of to diagnose incipient damage in persons exposed to bronchial noxae. In the present investigation the effect of smoking on the airways was studied in a group of 25 persons aged 20-25 years by determining the closing volume and differences in ventilatory distribution (Thews method). The results were compared with those obtained in a group of 27 non-smokers in the same age group.

Adult↗
PubMed1979

[Polychemotherapy of inoperable bronchogenic carcinoma: preliminary results (author's transl)].

Preliminary results indicate that BACO and SAKK are capable of inducing remission in 80-90% of cases of small-cell bronchogenic carcinoma; these remissions last for about 6 months and not only prolong, but improve the quality of, life. In view of the small number of cases so far observed no assessment can as yet be made of the superiority of one or the other method concerning the incidence and duration of remissions and survival time. In cases of squamous cell cancer the two therapeutic methods succeeded in only 30-40% of the patients in inducing partical remissions and they did not appear to improve the quality of life. The question whether the treatment actually prolongs life as compared with the natural course of the disease remains open.

Antineoplastic Agents↗
PubMed1978

[Desquamative interstitial pneumonia. Peripheral eosinophilia in DIP: a new clinical aspect (author's transl)].

It were Liebow et al. (1965) who, for the first time, described the desquamative interstitial pneumonia (DIP) as one clinical and morphological unit. The etiopathology of this disease is still unknown and there exist many controversial opinions as to its role within the interstitial pneumonias. For the clinical-physician the DIP represents a difficult problem because there seems to be no uniform appearance to this disease. So a lung-biopsy is the unique way to make a definitive diagnosis. The following description represents a case of DIP observed at our hospital. At the same time we tried to give a review of our present knowledge concerning the morphology, course and therapy of this disease. We think it should be note that the DIP was accompanied by an extreme peripheral eosinophilia. To our knowledge this is the first time such a phenomenon is described. In the course of the treatment with steroids the eosinophilia disappeared parallel to the normalization of the radiographic findings.

Adrenal Cortex Hormones↗
PubMed1978

[Pathological and roentgenographic morphology in different stages of pulmonary shock (author's transl)].

Pulmonary shock syndrome may be better understood by comparing morphological and patho-physiological alterations in different stages. In the very early stage only fine structural tracer studies in experimental animals elicit morphological alterations of the microcirculation in the alveolar wall. These findings can be related to changes of ventilatory and blood-gas parameters. After a short interval microscopic and radiological features correspond. Interstitial pulmonary edema is the main syndrome of shock lung.

Adult↗
PubMed1977

[Cardio-pulmonary parameters after myocardial infarction in the late period of recovery. Investigation at rest and during exercise (author's transl)].

From 22 patients in the late period of recovery from myocardial infarction, cardio-pulmonary data were recorded at rest and during exercise. The physical work was increased stepwise until patients reached their individual limit of exercise. According to the different work capacity four groups of patients were formed with the aim to demonstrate the adaption processes of cardio-pulmonary parameters until reaching the peak of work capacity. In one half of the patients we still found signs of cardial insufficiency at rest. After only slight physical work signs of cardiac insufficiency appeared also in the other half of patients.

Female↗
PubMed1976

[Pulmonary gas exchange after myocardial infarction in the late period of recovery. I. Investigation at rest].

In the late period of recovery after myocardial infarction (13-25 months p. infarctum) lung function of 23 patients was examined at rest. Spirometric values and parameters of pulmonary gas exchange showed alterations caused by pathological left ventricular function. Arterial Po2 was slightly decreased (chi=74.5 +/- 5.9 Torr), AaDo2 (chi=33.6 +/- 7.7 Torr) and aADco2 (chi=8.6 +/- 3.7 Torr) were increased. Pathological changes of arterial Pco2 (chi=40.6 +/- 2.5 Torr) were not observed. Mixed venous Po2 and cardiac output in 9 patients suggested cardiac failure. In a number of pulmonary parameters measured at rest correlations could prove a dependence on the patients physical work capacity.

Carbon Dioxide↗