Intestinal function in malnourished children.
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Biomedical subjects
Publications and source records attributed to V Reddy.
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The secretory IgA system was investigated in children with protein-calorie malnutrition (PCM). The results of the study indicated that in children suffering from kwashiorkor and marasmus the concentration of IgA in duodenal fluid, saliva, nasal secretions, and tears was significantly reduced on admission and returned to normal 4 weeks after treatment. However, the concentration of secretory IgA in children with mild to moderate PCM was similar to that of normal children. Secretory IgA deficiency may be an important factor in promoting bacterial growth and this may account for the increased incidence and severity of mucosal infections in children with severe PCM.
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Absorption of labelled vitamin A was studied in normal children and in children with round-worm infestation. Absorption of the vitamin was significantly low in children with ascariasis. In two subjects, in whom the studies were repeated, absorption of vitamin A was significantly increased after antihelminthic treatment. These results suggest that ascariasis may aggravate vitamin A deficiency by interfering with the absorption of the vitamin.
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