Congenital anastomosis between the vertebral artery and internal carotid artery in the neck. Case report.
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Biomedical subjects
Publications and source records attributed to V Reddy.
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Plasma vitamin A and vitamin E levels were determined in 45 children. Seven normal children and 7 children with vitamin A deficiency were given daily supplements of 100 mg vitamin E for two weeks. Seven others received a placebo and served as controls. The mean levels of plasma vitamin E and A were 694 microgram/dl and 21 microgram/dl respectively. There was no correlation between plasma levels of the two vitamins. Administration of vitamin E resulted in a significant increase in plasma vitamin A concentration both in normal children and in those with vitamin A deficiency, while there was no change in the control group.
A hospital cum community based study indicated that rose Bengal staining of the eye could not only confirm clinically diagnosed cases of conjunctival xerosis but also detect those missed by clinical examination. However, some cases thus detected did not respond to a massive oral dose of vitamin A.
Alkaline RNase activity was measured in plasma and leucocytes of pregnant and non-pregnant women belonging to low and high socio-economic groups. It was observed that the enzyme activities were significantly higher in pregnant as well as non-pregnant women of the low socio-economic group as compared to women of the high socio-economic group. There was no correlation between the enzyme activities in maternal or cord blood on the one hand and birth weight of the infants on the other. These results suggest that RNase activities in maternal blood reflect the nutritional status of the mother but not that of the fetus.
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RNAase activity was measured in plasma and leucocytes of manourished children. In subjects suffering from kwashiorkor, alk. RNAase levels in plasma and leucocytes were markedly raised and they returned to normal after therapy. However, the enzyme activity was not altered in undernourished children. These data indicate that circulating level of alkaline. RNAase is not a useful parameter for detecting milder grades of protein-calorie malnutrition (PCM).
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Levels of immunoglobulins, lactoferrin and lysozyme were determined in milk samples obtained from well-nourished and under-nourished Indian women at different stages of lactation. The concentration of immunoglobulins and lactoferrin was higher in colostrum than in mature milk while the lysozyme levels showed a progressive increase with the period of lactation. There were no significant differences in the levels between the two groups of women. Administration of iron did not alter either the total or percentage saturation of lactoferrin in milk. These results indicate that antibacterial factors in milk are not influenced by the nutritional status of the mother and that iron supplementation does not interfere with the bacteriostatic function of lactoferrin.
Cell-mediated immune response and circulating levels of immunoglobulins were studied in 75 full-term newborn babies. The results showed that though the immunoglobulin levels were not altered, cell-mediated immunity was significantly depressed in infants with birth weight less than 2 500 g and this may result in lowered resistance of infection.
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Hematological studies were carried out in 110 children with varying levels of plasma retinol to investigate the relationship between vitamin A deficiency and anemia. In children with plasma retinol levels below 20 microgram/100 ml, the mean levels of hemoglobin and hematocrit were lower than those in children who had retinol levels above 20 microgram/100 ml. Following supplementation of vitamin A, there was a significant increase in the levels of hemoglobin, hematocrit and plasma iron. These findings suggest that apart from deficiency of iron, vitamin A deficiency may also have a contributory role in the development of anemia in children.
Various functional parameters involved in resistance to infection were investigated in children suffering from varying grades of protein-calorie malnutrition. It was observed that the phagocytic function was impaired in children whose weights were below 80% of the Indian Council of Medical Research standard, whereas the cell-mediated immune response was altered in those with weights below 70% of the standard. Antibody response to typhoid antigen was impaired in children with severe protein-calorie malnutrition, while the response to diphtheria and tetanus toxoids was normal in all. These observations suggest that malnourished children whose weights are below 80% of the Indian standard are likely to suffer from at least one functional handicap which may increase the risk of infection. In any action-oriented program, priority should, therefore, be given to this group of children.