Content of free bradikinin, kininogen and kininase activity were studied using biological methods in blood serum of 112 patients with goiter, of 20 patients with instrangulated hernia and of 21 healthy persons. The patterns studied were similar to normal value in patients with euthyroid goiter and instrangulated hernia. Thyrotoxicosis (63 patients) was accompanied by increase in all the patterns studied and the alterations were most pronounced in severe form of the impairment. Content of kininogen and kininase activity were increased about 2-fold and bradikinin content--5-fold. Content of free bradikinin was increased and kininase activity was decreased in all groups of patient within 1--3 days after the operation. Content of kininogen was increased in euthyroid goiter and decreased in thyrotoxic one. Patterns of kinine system trended to normalization within 6 days after the operation.

Adult↗

PubMedDate not supplied

[Proteolytic enzyme inhibitor and the kinin system in thyrotoxicosis].

Free bradykinin, kininogen, kininase, protease inhibitors of alpha 1-antitrypsin, alpha 1-antichymotrypsin, alpha 2-macroglobulin, and antitryptic volume of the blood serum were examined in 25 patients suffering from goiter with thyrotoxicosis symptoms. Activation of the kinin system and reduction in the antitryptic volume were revealed before the operation. The level of the rest inhibitors was elevated. After operative intervention these changes became more expressed. alpha 2-Macroglobulin content increased. By the moment of discharge the above parameters tended to normalization. The content of the majority of inhibitors, however, did not reach normal. This should be taken into consideration during rehabilitation of patients with thyrotoxicosis.

Adult↗

PubMedDate not supplied

[Indirect thyroidolymphography in the diagnosis of thyroid diseases].

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Adolescent↗