[Kinin dynamics and inhibitor therapy of thyrotoxicosis patients].
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Biomedical subjects
Publications and source records attributed to V P Fesenko.
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Under investigation were 151 patients with peptic ulcer (68), postresective disorders (8), non-incarcerated hernias (20), chronic gastritis (11), appendicitis (7), cholecystitis (5) and healthy people (32). The ulcerous disease, especially when complicated, is accompanied by increased activity of the kallikrein-kinin system. Certain deviations are observed in postresective disorders. These disorders were found to increase within the first day after operations on the stomach and in less degree after other interventions. Later these symptoms tended to normalize. The kinin activity was influenced by the severity of the operation trauma and anesthesia. Sufficient preoperative preparation and use of kontrikal resulted in less disturbance in the kinin system.
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A new technique for prevention of asphyxia in tracheomalacia has been developed. The technique consists in suturing the softened portion of the trachea to the dura mater graft which had been previously fixed to its healthy portions. Such a technique allows performing reliable fixation of the tracheomalacia portion in an extended state and thereby to prevent asphyxia, The technique was used in 11 operated patients and gave good results.
The authors used paranephric, vagosympathetic and vagoganglionic blockade in 253 patients with acute cholecystitis, cholecystopancreatitis and pancreatitis. The universally adopted methods were used for the estimation of the results with the recording of electrogastrogram before the blockade, immediately after novocaine injection and on hour later. The arrest or subsiding of pain syndrome occurred after paranephric blockade in 78.8% of patients, after vagosympathetic blockade in 95.2% and after vagoganglionic blockade in 92.6%. 20 patients were operated upon.
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The authors studied 939 patients with acute pancreatitis; 144 of them were operated upon. Total postoperative mortality was 18%; of them 1.05% mortality was due to a mild form and 51.0% mortality occurred in pancreonecrosis and purulent pancreatitis. In extensive necrosis and abscess formation the drainage of the abdominal cavity and retroperitoneal space is recommended. The authors believe that omentopancreatopexy should be applied in oedematous and hemorrhagic forms of pancreatitis and in focal necrosis, as well.
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