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Biomedical subjects

V N Polysalov

Publications and source records attributed to V N Polysalov.

At least 19 recordsLinked to original sources
PubMed2003

[Long-term results of local ethanol injection therapy in the treatment of hemangiomatosis of the liver].

During the period from 1989 till 1998 local ethanol injection therapy (LEIT) was used in treatment of 37 patients aged 39-78. The multiple focused form of hemangioma of the liver was observed in 15 (41%) patients, solitary in 20 (54%), the diffuse-focused in 2 (5%) patients. The distribution of the tumors according to the histological structure was as follows: cavernous hemangioma in 22 (60%) patients, capillary--in 2 (5%) patients, mixed in 13 (35%). Local injection therapy was the only method of treatment of 17 patients. In 13 patients this method gave insufficiently effective embolization of the hepatic artery, in 2 patients the injection therapy was combined with ligation of the hepatic artery and in 5 patients--with resection of the liver because of another tumor. The volume of a single use of ethanol varied from 6 to 60 ml. Long-term results were followed-up during 3-6 years. By the data of USI, CT, NMR in all the patients there were changes in the tumor typical of fibrosis. Positive results of the treatment such as a reduced size of hemangioma were noted in 27 patients (73.0%), pains disappeared in 10 out of 29 patients (35%) who had pain syndrome. A conclusion is made that local ethanol injection therapy with 96% ethyl alcohol is effective in treatment of hemangioma of the liver. It gives good long-term results including a combination with the endovascular treatment and resection of the liver.

Adult↗
PubMed2003

[Colorectal cancer with synchronous metastatic involvement of the liver: results of single- and two-stage operations].

The data on the treatment of colorectal carcinoma and synchronous metastatic involvement of the liver in 41 patients are presented. After extensive resections, complications were reported in 45.5%, partial--12%. Post-operative mortality was 4.9%. Relapse-free survival in group 1 was 8.9 +/- 2.7 months, group 2-9.7 +/- 3.1 months. Hepatic tumor progression within 3.5-39 months (9.1 +/- 2.4 months) was registered in 73.2%. Average survival in patients who had single-stage surgery was 23.1 months, after metachronous operations--23.7 months. Five-year survival rate was 12.1%.

Adult↗
PubMed2002

[Preoperative embolization of the portal vein in malignant tumors of the liver: preliminary results].

Preoperative embolization of the right portal vein and following hepatic resection were performed in seven patients with primary and secondary liver malignancies. The indication for the procedure was a small amount (30%) of the future remnant liver (FRL). The ultrasound-guided percutaneous transhepatic puncture of the portal vein and its embolization with gelatin sponge or silicon polymer was used. No complications of the procedure were noted. In 19-56 (mean 33) days computed or magnetic resonance tomography showed a significantly increased FRL volume (mean 40%). Right or extended right hepatectomy was performed in 5 and 2 patients respectively without lethal outcomes. A conclusion is made that the preoperative portal vein embolization is a safe and technically simple procedure that reduces the risk of postoperative hepatic failure after major liver resection.

Adult↗
PubMed2000

Ischemic complications of transcatheter arterial chemoembolization in liver malignancies.

OBJECTIVE: To determine the frequency, character, methods of treatment, and outcome of ischemic complications after transcatheter hepatic artery chemoembolization (TACE). MATERIAL AND METHODS: Between 1985 and 1998, 827 sessions of TACE with Doxorubicin mixed with iodized oil, and gelatin sponge particles were performed in 282 patients with primary and metastatic liver cancer. Post-TACE monitoring included clinical observation, US and CT. RESULTS: Ischemic complications appeared in 13 (4.6%) and included the following: hepatic (n=6) and splenic abscess (n= 1), cholecystitis (n=3), and bile duct necrosis (n=3). The treatment was US-guided drainage in 12 cases and systemic antibacterial therapy in 1. No negative influence of these complications on survival of patients was detected. CONCLUSION: Serious ischemic complications of TACE occur in about 5% of patients and can be successfully managed without open surgery. These complications do not worsen the survival of patients.

Adult↗
PubMed1999

[Arterial embolization in treatment of hepatic cavernous hemangioma].

Clinical and radiologic results of hepatic artery embolization (HAE) were retrospectively analyzed in 32 patients with cavernous hemangioma of the liver. Embolization was the only method of treatment of the hemangioma in 25 of 32 patients. HAE was effective for improvement of symptoms such as abdominal pain, anemia, rapid tumor enlargement, portal or systemic hypertension due to intratumoral arterioportal or arteriovenous fistulas. On the other hand, symptoms of hepatic tumor improved in only two patients but became worse in four of 14 patients with non-severe disease. During one to five years of follow-up, reduction of arterial supply of hemangioma was seen in all the patients, but the tumor size decreased in only 1/3 of them. It is concluded that individual approach to the use of HAE and other treatment modalities should be preferred in patients with hepatic cavernous hemangioma.

Adult↗
PubMed1998

Extraorganic hepatic artery aneurysm: failure of transcatheter embolization.

Hepatic artery aneurysm (HAA) was diagnosed in a 62-year-old man who was a poor candidate for surgery because of severe liver cirrhosis and diabetes mellitus. Two attempts to occlude the HAA by transcatheter embolization failed because of recanalization of the aneurysm. Moreover, aneurysmal dilatation of the superior mesenteric artery and the left renal artery developed and progressed. Both the literature and the present case show that an individual approach to treatment of extraorganic HAA should be chosen in dependantan location and anatomy of the lesion.

Aneurysm↗
PubMed1997

[Puncture sclerosing treatment of nonparasitic liver cysts].

The article describes the method and results of the puncture sclerotherapy of nonparasitic liver cysts in 30 patients. Cooled to -28 degrees C 96% ethyl alcohol was used as a sclerosing agent. The total destructive effect of the agent was obtained due to the combination of its chemical and physical (temperature) factors. Complete recovery was obtained in 86.6% of the patients. The puncture sclerotherapy can be used as a medical alternative for nonparasitic liver cysts.

Cysts↗
PubMed1995

[Combined radio-endovascular and percutaneous procedures in the treatment of liver hemangioma].

A spectrum of roentgenoendovascular and percutaneous procedures of hepatic hemangioma treatment is considered for situations in which resection of the liver is not justified. Stage I of therapy involved embolisation of hepatic artery and its branches. At stage II, ultrasonography and roentgenoscopy-controlled aiming percutaneous puncture and sclerosation of hemangioma were conducted. Said procedure was used in treatment of 12 patients. The results were evaluated using scintigraphy, ultrasonography, computed tomography and aiming puncture biopsies.

Administration, Cutaneous↗
PubMed1994

[Combined arterial and intraportal therapy of hepatocellular carcinoma: preliminary results].

Tentative results of consecutive arterial and portal chemoembolizations in 4 patients with advanced hepatoma are presented. Hepatic artery occlusion was achieved by administration of 20-60 mg adriablastin in 6-12 ml iodized oil and minced gelatin sponge. Said adriablastin-in-oil alone was used for transhepatic catheterisation and chemoembolization of portal vein 2-4 weeks later. The patients received a total of 10 courses of combined therapy, without any complication development. All the patients have been alive for 18 months and two of them have been in remission. The preliminary results of application of the new modification of transcatheter management of primary hepatoma are encouraging and make the case for undertaking prospective randomized clinical trials.

Adolescent↗
PubMed1992

[A differential approach to the surgical treatment of liver hemangiomas].

Treatment results and indications for surgery were analysed in 50 cases of hepatic hemangioma versus pattern of hemangiomatosis and size, site and extent of tumor. Surgery was performed in 41 (82%) patients. Radical surgery was possible and justified in as few as one-third of them. Palliative treatment including ligation and roentgen-endovascular occlusion of the hepatic artery and its branches, local ferromagnetic embolization of tumor and suturing and sclerotherapy of hemangioma were performed in 28 cases. End results were analysed in 33 cases followed up to as long as 8 years posttreatment. The extent and type of surgery for hepatic hemangioma should be different for each of the four patterns of the disease identified.

Adult↗
PubMed1992

[Blood group assignment--a genetic marker of hepatic hemangiomatosis].

There is no single point of view on pathogenesis of hemangiomas. The authors investigated the ABO blood types in 52 patients with hepatic hemangiomas (Group 1) and 1000 control patients (Group 2). The study demonstrated 61.5% of the A blood type among the patients of Group 1. This was significantly higher than in the Group 2 and representative groups from literature (P less than 0.001). Taking into account that the cells of both blood and blood vessels are formed in embryos through the mesenchyma and the heritability of blood group antigens, it is supposed that the results obtained support the genetic determination theory of pathogenesis of hepatic hemangiomas.

ABO Blood-Group System↗
PubMed1991

[Embolization of the hepatic artery in the treatment of malignant tumors of the liver].

The results of therapeutic hepatic artery embolization (HAE) in 25 patients with malignant unresectable tumors of the liver are discussed. The proximal segments of the hepatic artery were occluded by metal spirals. Thrombosis of the portal vein was accepted as an absolute contraindication for HAE, and a tumor involving more than 50% of the volume of the liver and chronic hepatic insufficiency were considered relative contraindications. After the intervention signs of subjective improvement were noted in 73.9% and signs of objective improvement in 65.2% of cases. The mortality after HAE was 4.2%. The obtained results are evidence of the efficacy of proximal HAE as a method for the treatment of inoperable malignant tumors of the liver.

Adenoma, Bile Duct↗