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Biomedical subjects

V N Orlov

Publications and source records attributed to V N Orlov.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Assessment of blood platelet status in acute myocardial infarction].

Circulating platelet morphology (using scanning electron microscopy), platelet adhesion and flattening on silicone slides (interference contrast microscopy), and spontaneous platelet aggregation were investigated. Platelet status was thus assessed in patients with acute myocardial infarction (AMI), chronic coronary disease (CCD) and normal subjects (controls). In AMI patients, the majority of circulating platelets were inactivated: 70% and more were of smooth discoid shape, a finding similar to that of the controls. On the contrary, platelet flattening, adhesion and spontaneous aggregation were changed in AMI patients, and also, though on a smaller scale, in CCD patients. Changes in platelet flattening ability were most pronounced, the latter parameter being sharply increased in 73% of AMI patients.

Adolescent↗
PubMed1982

[Indices of sympathetic-adrenal system and renin activity in ischemic heart disease before and after obzidan treatment].

In 78 patients with ischaemic heart disease prior to and after treatment with obsidan the authors examined relationship between the indices of activity of the sympatho-adrenal and renin systems. A correlation analysis was made between the data adrenalin excretion, noradrenalin, dopamine and DOPA in the urine and renin activity in the blood. After obsidan treatment the excretion of adrenaline and renin activity in blood plasma diminish. After obsidan treatment different links of activity of the sympato-adrenal system function more conjointly. Change in the activity of one of the links produces corresponding changes in the activity of the others. Dependence of renin activity is shown to exist on the activity of the sympatho-adrenal system after treatment as compared to their levels prior to treatment . The initial background recorded prior to treatment influences significantly the final result of treatment. A negative correlation exists between the activity of the sympatho-adrenal system and renin which is regarded as evidence of protective compensatory reaction of the body. It is suggested that the increase of noradrenalin secretion, causing rise of the blood pressure is associated with the compensatory decrease of renin activity.

Adrenal Glands↗
PubMed1982

[Effect of lidocaine on thrombocytic hemostasis].

New antiaggregative and antianginal effects of an oral antiarrhythmic drug, lidocaine, are reported. Platelet hemostasis was investigated in 55 patients, with platelet function and morphology examined prior to and seven days after the onset of the lidocaine treatment. A significant decrease was noted in platelet aggregation with the dose of 2.5 (2.3-2.7) mg lidocaine per 1 kg of body weight taken four times daily at least. As the dosage increased, the drug antiaggregative properties were enhanced accordingly. Large doses, however, were associated with side-effects. The reported dose produced a nearly two-fold reduction in platelet aggregation rate, and anginal attacks were arrested in 80% of the patients, whereas platelet morphology was not affected.

Adolescent↗
PubMed1981

[Modern concepts of the ECG changes in branch block of the bundle of His and of the ramifications of the left branch].

The author reports on the modern conceptions on the structure of the interventricular conduction system, classification and the diagnostic signs of the block of pedicles of His bundle and the branches of the left pedicle. ECG signs of the block of the left and right pedicles of His' bundle are described. ECG changes in the block of the anterior and posterior branches of the left pedicle are given. The combined types of blocks are discussed: block of the right pedicle of His' bundle and the anterior branch of the left pedicle, block of the right pedicle and the posterior branch of the left pedicle. It is pointed out that the combination of the block of the left pedicle and of the anterior branch of the left pedicle is possible. The symptoms of a bilateral and three bundle blocks are given. A focal intraventricular and non-specific intraventricular blocks, and masked block of the pedicle are described. The intraventricular blocks are subdivided into complete and incomplete and their ECG characteristics are given.

Bundle of His↗