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Biomedical subjects

V Moore

Publications and source records attributed to V Moore.

At least 55 records · Page 3Linked to original sources
PubMed1984

Cerebral palsy in Riyadh, Saudi Arabia: I. Aetiological factors.

Aetiological factors predisposing to cerebral palsy were investigated in 190 children with this condition seen in Riyadh , Saudi Arabia since January 1980. Ninety-four (49.5%) of the cases were natal in origin, 63 (33.1%) prenatal and 33 (17.4%) postnatal. Anoxia was the most common aetiological factor, accounting for 38 cases (20%), followed by prematurity in 18 (9.5%). These two factors combined accounted for 29.5% of all cases and 59.5% of those in the natal group. Idiopathic cases, the third largest group, accounted for 9.0%. Certain factors were shown to predispose to specific neurological deficits, the majority of the 190 patients being spastic diplegic (31%) or quadriplegic (26.3%). Saudi Arabia is going through a process of massive economic, social and medical progress. In view of improvements in all these areas and of other factors, a change in the pattern of incidence of cerebral palsy in Saudi Arabia is expected in the future.

Age Factors↗
PubMed1984

Cerebral palsy in Riyadh, Saudi Arabia: II. Associations between gestational age, birthweight and cerebral palsy.

One hundred and ninety infants with cerebral palsy were studied in Riyadh , Saudi Arabia. Bleeding during pregnancy and toxemic complications seemed to be important causative factors, particularly in preterm and small-for-date infants. Infants born after breech presentation, assisted labour and failed obstetric procedures totalled 20.0% of all cases. Poor feeding, stiffness and infection were the main clinical presentations. Spasticity was the predominant neurological abnormality irrespective of birth weight, with spastic diplegia (31.0%) and quadriplegia (26.3%) contributing greatly to the overall pattern. Speech defects and, to a lesser extent, epilepsy were the most frequent associated handicaps. The majority of children with cerebral palsy (65.8%) were severely handicapped. Saudi Arabia is making rapid economic, social and medical progress, but currently facilities to meet the needs of cerebral palsy victims and their families are inadequate. Based on the above study it is recommended that: (1) paramedical services at community level be initiated; (2) more rehabilitative and educational programs be established; (3) better and more modern obstetric care be provided; (4) close co-operation among the medical professionals be facilitated since cerebral palsy cases can be managed best through a team approach.

Birth Weight↗
PubMed1983

Paroxysmal cold hemoglobinuria in a patient with Klebsiella pneumonia.

A case of paroxysmal cold hemoglobinuria (PCH) occurring in a patient with Klebsiella pneumonia is described. The first sign of PCH in the patient was erythrophagocytosis. The Donath-Landsteiner (D-L) antibody exhibited anti-P specificity both serologically and biochemically. The appearance of D-L antibody during fulminating Klebsiella pneumonia strongly suggests their causal relationship.

Bronchopneumonia↗
PubMed1979

A study of HLA-A, B, C, and DR specificities in pigeon breeder's disease.

The frequencies of HLA-A, -B, and -C antigens were determined among 51 symptomatic pigeon breeders, 102 asymptomatic pigeon breeders, and 100 normal blood donors. The HLA-DR specificities were also studied in 32 symptomatic and 29 asymptomatic pigeon breeders. All subjects were white. Symptomatic subjects were defined by the development of respiratory symptoms or decreased pulmonary function after aerosol challenge with pigeon serum. Asymptomatic subjects were comparably exposed to pigeons but had no pulmonary signs or symptoms after aerosol challenge. No significant association was found between any of the tested HLA specificities and pigeon breeders. This lack of association and the observed paucity of multiplex families indicate that HLA complex genetic factors tested in this study do not favor the development of pigeon breeder's disease in exposed persons.

Alveolitis, Extrinsic Allergic↗
PubMed1979

A randomized controlled trial of geriatric screening and surveillance in general practice.

A randomized controlled trial of geriatric screening and surveillance was undertaken on a practice population of 295 patients aged 70 years or more over a two-year period. In the screened group (145 patients) many social problems were found and a total of 380 medical conditions were reported during the study period, 144 (38 per cent) of which were previously undetected. Conditions found most frequently involved the circulatory, musculoskeletal and nervous systems; 67 per cent of the conditions found were manageable, half being improved and the remainder resolved completely.The screening programme was found to increase the use of social and health services but it did also decrease the expected duration of stay in hospital.Independent assessment of patients in the study and control groups at the end of the two-year period showed that the screening programme had made no significant impact on the prevalence of socio-economic, functional, and medical disorders affecting health.We formed the firm impression that the study patients were made more comfortable (by control of pain) and less disabled, although there was no unequivocal objective evidence of this. They were, however, kept independent for longer.The findings are discussed and a model of geriatric care is suggested combining conventional management on demand with comprehensive screening to identify the high-risk patients on whom care might need to be focussed.

Aged↗
PubMed1976

Pigeon breeder's disease. II. Pigeon antigen induced proliferation of lymphocytes from symptomatic and asymptomatic subjects.

Lymphocyte reactivity to pigeon antigens was demonstrated in a patient with severe symptomatic pigeon breeder's disease (PBD). The reactivity of the lymphocytes declined subsequent to cessation of exposure to antigen and in parallel with clinical improvement. Lymphocyte reactivity was also demonstrated in another patient with PBD, in a pigeon breeder with no evidence of PBD, and in a laboratory investigator with a history of exposure to birds other than pigeons. Lymphocyte reactivity in the latter subject increased following cutaneous injection of pigeon serum with the development of delayed-type cutaneous reactivity. Although lymphocyte reactivity to pigeon antigens may be a necessary immunologic feature for production of PBD, this reactivity does not occur only in symptomatic subjects.

Animals↗
PubMed1976

Pigeon breeders disease. III. A study of a family exposed to doves.

A family of five individuals exposed to doves in their home were studied to evaluate possible factors leading to sympotmatic hypersensitivity pneumonitis documented in one member of the family, while the other exposed members remained asymptomatic. Antbodies against pigeon serum were domenstrated by radioimmunoassay in all subjects, and significant lymphocyte reactivity against pigeon antigens was demonstrable in three of the five members. The presence of serum antibody activity or lymphocyte reactivity against avian antigens or both did not differentiate the sick from the well family subjects. However, the possibility that increased exposure to antigen may correlate with higher degrees of antibody and lymphocyte reactivity as well as clinical disease is suggested from observation made in this family. No correlation was found between HL-A type and either symptomatic disease or immunological reactivity in these subjects.

Adolescent↗
PubMed1975

A successful new primary health care provider in the newborn nursery.

The mothers' acceptance of the Child Health Associate ("CHA") as a qualified health professional and the documentation of CHA's clinical abilities to provide broad-based health care for normal infants attest to their capabilities to function as primary health care providers in a newborn nursery. In "low-risk" nursery settings, where other capable health professionals may not be available, the CHA can assume primary and direct responsibility for the care of the normal newborn infant.

Adult↗
PubMed1972

Production of metastases by a primary tumour irradiated under aerobic and anaerobic conditions in vivo.

The effect of local irradiation of a rapidly metastasizing sarcoma in the leg of the rat was measured in terms of (a) regression of the primary tumour and (b) growth of metastases produced in lymph nodes and lungs, by dissemination occurring after irradiation of the primary tumour. These effects on rats which had been irradiated while breathing air were compared with rats breathing 10% O(2)/90% N(2) in which a tourniquet had been applied proximal to the tumour to arrest blood flow during irradiation. Tourniquet anoxia increased radioresistance of growth of primary tumour by (OER) factors of 2·9-3·3. Corresponding factors for inhibition of growth of metastases in abdominal lymph nodes, and for the reduction in incidence of lung metastases produced by single tumour cells, were 2·7 and 2·4 respectively. These results suggest that this tumour was radiobiologically well oxygenated when it was irradiated in a poorly vascularized stage of growth where tumour necrosis had developed.

Aerobiosis↗
PubMed1971

Growth of metastases from P-388 sarcoma in the rat followig whole body irradiation.

The growth of an allogeneic rapidly growing and metastasizing sarcoma (P-388) in the rat is described. Quantitative and kinetic data are provided concerning the growth of individual metastases produced in three principal regional lymph node drainage groups, and are compared with growth of the primary tumour of origin in muscle; the incidence of pulmonary metastases is also given. The effects on growth of metastases and primaries produced by sublethal whole body irradiation (WBI) before inoculations of 10-10(8) tumour cells are described.Growth of P-388 sarcoma in unirradiated recipients (ED(50) ≃ 5 × 10(3) cells) obeyed the linear growth law proposed by the Mayneord model for tumour growth, but in irradiated recipients (ED(50) < 10 cells) early growth of primaries and metastases approximated more closely to an exponential rate of growth.The ratio M/P of weight of metastases (M) to weight of primary tumour of origin (P) increased at a linear rate with age (t) of tumour, and gave the same slope namely, 0·029 for pelvic node metastases) in unirradiated rats inoculated with a large (10(6)-10(7)) number of cells as in irradiated rats. The slope was decreased to 0·014 for pelvic node metastases in unirradiated rats challenged with fewer (10(4)) cells but not in irradiated recipients. It is postulated that the effects of WBI on growth of metastases are confined to causing a suppression of immunity, and that WBI does not affect tumour spread significantly through other mechanisms.In immunologically competent rats the phenomena of sequestrated progressive growth of isolated metastases in lymph nodes and of a chronic nonprogressive enlargement of nodes in which persistent tumour growth and destruction occurred side by side are described, and effects on prognoses and clinical behaviour, are discussed.The P-388 tumour is considered of value in quantitative and kinetic experimental studies of metastases, and particularly those in which the role of immunity needs to be assessed and measured to avoid confusion with other factors or agents which might affect the spread and growth of metastases.

Animals↗