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Biomedical subjects

V Masini

Publications and source records attributed to V Masini.

At least 19 recordsLinked to original sources
PubMed1993

Cutaneous bioavailability in hairless rats of tretinoin in liposomes or gel.

Topical bioavailability of drugs incorporated in liposomes is not well known. We compared the skin penetration of tretinoin in liposomes and in a classical alcoholic gel. [3H]Phosphatidylcholine dipalmitoyl (DPPC) and [14C]tretinoin (0.14%) were incorporated in the phospholipidic phase of the liposomes, and [14C]tretinoin was incorporated in a gel for comparison. Skin absorption was studied in vitro with Franz cells. In vivo distribution in cutaneous structures was studied according to Schaefer's method. Liposomes impregnated the stratum corneum, with a partial dissociation between tretinoin and phosphatidyl-choline dipalmitoyl. In dermis, tretinoin diffused alone. Tretinoin release seemed to be controlled, and steady state was reached later with liposomes than with gel. This phenomenon was linked with a significantly reduced absorption (1.60% for liposomes versus 3.09% for the gel) and higher retention in epidermis (mainly stratum corneum) and dermis (41 and 13%, respectively, with liposomal form versus 18 and 8%, respectively, with gel form). This study clearly shows that, compared with the gel, the liposome formulation tends to improve the local effect of tretinoin in the skin and decrease the systemic absorption.

1,2-Dipalmitoylphosphatidylcholine↗
PubMed1983

[Clinical aspects and diagnostic criteria in non-obstructive symmetric hypertrophic myocardiopathy].

We describe the clinical data, the standard and Holter electrocardiographic observations, the carotid pulse tracings, the M-mode and B-mode echocardiographic findings and the left ventriculographic aspects of 21 patients with non-obstructive symmetric hypertrophic cardiomyopathy (NOSHCM). NOSHCM was diagnosed when there was echocardiographic and/or left ventriculographic evidence of septal and posterior wall hypertrophy without signs of left ventricular outflow destruction (LVOTO). Compared to the asymmetric hypertrophic obstructive cardiomyopathy (AHOCM), NOSHCM reveals reduced excursion of the posterior wall of the left ventricle, whereas patients with AHOCM have more frequently systolic murmurs and carotid pulse changes suggestive of LVOTO. Proper classification and treatment of NOSHCM are discussed.

Adult↗
PubMed1983

[Health education: general concepts].

A short history of the birth and evolution of the concept and present definition of Health Education is presented. As the purpose of the Health Education is to change the individual and collective attitude to health, and since it is an active educational process, it is necessary to act on the cognitive and operative sphere. Health Education should be inserted in all the programs of the Social and Health Services including hospitals. Hospital cardiological units should also fulfil this important role with regard to the largest group of social illnesses: Cardiovascular Diseases.

Cardiology↗