Incidence and character of lipoproteinemia in underground and surface workers at the Goroubso Works, Zlatograd.
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Biomedical subjects
Publications and source records attributed to V Markova.
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The course of pregnancy and its final outcome--delivery of alive and viable fetus, is of special significance for women becoming pregnant after artificial insemination because of their limited possibilities for new pregnancy. 131 pregnancies, occurring after artificial insemination with fresh and frozen seminal plasma, were investigated. Analysis of the results showed that in basic lines the course of pregnancy and delivery as well as the state of the newborns did not differ substantially from those of normally conceived women. There was no statistical difference (p greater than 0.05) in the frequency of still-births, preterm deliveries and congenital anomalies of the fetus. In the course of pregnancy of women with artificial insemination two risk periods are determined. a) first trimester because of the greater frequency of spontaneous abortions b) delivery because of the increased operative activity and greater frequency of multiple pregnancy.
The fight against sterility in the family is of great psychosocial significance. Male infertility has not a small part of the causes for sterile marriage. 1470 sterile married couples were recorded in the dispensary system of the consulting room for the fight against sterility in the family at the district hospital in the town of Varna during the period of 1975-1986. Seminological examinations of the husband were performed three times and the final seminological diagnosis was established. The performed examinations showed clearly that almost 1/3 of men had seminological disturbances. The male infertility in sterile married couples increased on the average with 10.28% per year during the investigated period as for men with oligospermia this increase was higher (12.08%) in comparison with azoospermia (6.56%). Prognosis for advancement of disturbances in spermatogenesis was made on the basis of the collected information. The results showed a tendency to a general increase of the frequency of male infertility during the following years. An inference is made that it is necessary to improve work connected with prophylaxis, early discovery and treatment of diseases, which cause male infertility.
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Peripheral blood chromosomes of 13 patients with retinoblastoma and of their 20 first degree relatives were examined. In three of them chromosomal aberrations were found. Chromosomal anomalies were revealed in one case the patient's father only (the child died and the examination could not be performed) [del(13)(q12.11-q12.13)] and in another case both in the patient [t(13;14)] and in the father as well. This data support the view that some cases of retinoblastoma are closely linked to chromosomal rearrangements in the parental karyotype.
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The effect of piracetam on lipid peroxidation (LPO) in the rat brain was investigated. Piracetam was shown not to catalyze LPO and not to stimulate production of active forms of oxygen but to increase LPO only in the presence of traces of transition of metal ions. In all probability, the reason of this is the capacity of piracetam to chelate these metals. In this case their catalytic activity with respect to LPO increases. The performed studies demonstrate that the observed increase in LPO in the rat brain during the use of piracetam is an artefact due to the presence of traces of transition metal ions.