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Biomedical subjects

V M Klimenko

Publications and source records attributed to V M Klimenko.

33 records · Page 2Linked to original sources
PubMed1987

[Morphofunctional changes in the adrenergic innervation of the major cerebral arteries during bilateral electrostimulation of the locus coeruleus].

The intramural adrenergic nervous apparatus of cerebral arteries was studied in adult rabbits after 3-10 sessions of electrical stimulation of locus coeruleus. The activity of nerve structures was determined by estimating the density of adrenergic perivascular plexuses and by semi-quantitative cytophotometry of changes in the catecholamine content of nerve varicosities. The stimulation was followed by a 28.2 +/- 1.5% increase in adrenergic innervation density. while catecholamine content in perivascular nerve structures displayed a tendency to decrease. The problem of central effects on cerebral blood flow autoregulation is discussed.

Adrenergic Fibers↗
PubMed1985

[Morphofunctional restructuring of the nervous system of the lymphoid organs during electrostimulation of the hypothalamus].

The intramural nervous apparatus of rabbit lymphoid organs was examined after 15 and 30 sessions of electric stimulation of the posterior hypothalamus. The function of nerve cells was evaluated by cytophotometry according to the content of catecholamines and acetylcholinesterase (ACE) activity. In the mesenteric lymph nodes, stimulation led to a decrease in the activity of both adrenergic and ACE-containing nerve cells. The spleen demonstrated a reduction in the catecholamine content in the perivascular nerve plexuses, with a simultaneous rise of the catecholamine content in the fibers located in the parenchyma, which evidences inhibition of the neurogenous mechanisms of vasomotor control and possible selective activation of the sympathetic mechanisms involved in the regulation of the immunogenesis. Thymic preparations impregnated with silver salts manifested high argyrophilia of the nerve cells, characteristic of the reactive phase of the destructive process. The problems of the hypothalamic effects on the blood supply and functions of the immune system organs are discussed.

Acetylcholinesterase↗
PubMed1984

[Space-time functional organization of the brain subcortical structures in the process of developing immune reactions].

The functional states of subcortical brain structures were investigated with the aid of DC potential and EPs in the course of immune response. Change of the hypothalamic structures' functional state was the same after different antigen immunization during the 1st day of immune process and the latency of this process varied from 9 to 13 min. The inductive and productive periods of primary immune response developed with successive phasic changes in a number of subcortical structures.

Animals↗
PubMedDate not supplied

Spatial-temporal organization of subcortical brain functions during immune responses.

In the course of long-term experiments on rabbits, functional dynamics of subcortical structures were studied by recording background (DC) and evoked potentials (EP) during immune responses elicited to various antigens. During the first day of the immune response process to the different antigens, changes in hypothalamus functioning were similar and occurred with a latency of 9 to 31 min. Inductive and productive primary immune responses were accompanied by successive phasic changes in the functioning of a number of subcortical structures.

Action Potentials↗
PubMedDate not supplied

[Cytokine neurobiology: behavior and adaptive responses].

Reactions of the brain to systemic LPS or IL-1 beta treatment were shown to have different thresholds, be mediated by different neurotransmitter systems, and have different mechanisms of realisation. Changes in behaviour and neurotransmitter systems activity of the hypothalamus induced by a systemic IL-1 beta treatment were shown to be mediated by its receptors in the brain. Expression of mRNA of the tumour necrosis factor was revealed in the rabbit brain following administration of high pyrogenic doses of the LPS. The data obtained corroborate the concept of the cytokines role in maintenance of the defence responses in activation of the immune system, as well as their probable role in normal mechanisms of physiological functions control.

Adaptation, Physiological↗
PubMedDate not supplied

[Role of licking and concomitant changes in the excitability of nerve centers in the elaboration of gustatory information in rats].

The mechanism of nervous control of licking was studied in the frame work of the electrophysiological analysis of conditioned taste aversion. The licking rhythm is so stable that the rats are unable to slow it down by 20 percent. If the solution which was previously used for establishing the conditioned taste aversion, appears in the drinking spout, the rat stops drinking after one or two licks. Analysis of temporal relationships between afferent and efferent impulse activity of licking shows that the comparison of gustatory signals with memory traces and the corresponding decision occurs within 80 to 120 ms after lick onset. Electrical stimulation of the hypothalamic centres through implanted electrodes has shown that the amplitude of evoked responses and the impairment of licking increases, in proportion to the delay between lick onset and stimulus application. Isolated discharges of epileptic foci in the frontal cortex and the hypothalamus cause an omission of one or several licks, without interfering with the activity of the licking generator.

Animals↗