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Biomedical subjects

V Lakshminarayanan

Publications and source records attributed to V Lakshminarayanan.

62 records · Page 4Linked to original sources

Refractive changes induced by intraocular lens tilt and longitudinal displacement.

There is a tendency for the posterior chamber intraocular lens to tilt about the points of insertion. This is found clinically and in postmortem studies of eyes that have had intraocular lenses surgically implanted. One end is often located in the lens capsule and the other end is located in the ciliary sulcus. The possibility of anteroposterior displacement also exists. Using a modified Gullstrand schematic model eye, we have computed the amount of spherical and cylindrical errors that are induced due to the tilt and/or displacement of the intraocular lens. If a cylindrical error of approximately 90 degrees from the axis of insertion (lens plus haptic loops) and/or axis of tilt is detected, further careful investigation is warranted.

Astigmatism↗

The Stiles-Crawford effect of the first kind (SCE I): studies of SCE I in an aniridic observer.

The Stiles-Crawford effect of the first kind (SCE I), discovered in 1933, represented a major breakthrough in our understanding of retinal physiology and the modern beginning of the science of photoreceptor optics. The current status of knowledge in this area is briefly reviewed. A study is presented of a white adult female observer with aniridia, clear media, only traces of nystagmus, rather good visual acuity, and good fixation. It is shown that this individual exhibits approximate alignment of her photoreceptors with the center of the retinal sphere, clear evidence of side lobes on functions, and surprisingly steep SCE I functions. The implications of these findings are considered.

Adult↗

Optokinetic and vection responses to apparent motion in man.

Apparent motion was investigated as a stimulus for optokinetic nystagmus (OKN) and self-motion perception (vection). Apparent motion was stimulated by stroboscopically illuminating vertical stripes on the interior of a large drum that rotated about the observer at 20, 40 and 60 deg/sec. We determined threshold stroboscopic frequencies (f) for the appearance of smooth continuous apparent motion and measured responses of pursuit, OKN, optokinetic after nystagmus (OKAN) and vection, to stroboscopic frequencies at, above and below f. Pursuit occurred for all of these stimuli. However OKN, OKAN and vection only occurred for frequencies equal to or greater than the threshold for continuous apparent motion. Our results suggest that pursuit can occur as a response to apparent motion generated by both small and large image displacements, while OKN and vection are responses to apparent motion generated by small image displacements only. These results suggest that different afferent sources are utilized for the control of pursuit and of the slow phase of OKN.

Afterimage↗

Electromyographic evidence of neurological controller signals with viscous load.

Ensemble averaging after pre-editing of surface EMG potentials has enabled construction of underlying controller signals from stereotyped head movements. Carefully controlled, intended time-optimal movements by trained, actively participating human subjects have been found to yield repeatable, multi-pulse controller signals. Also, adaptive changes in these horizontal head movements in response to added viscous loads showed further causal relationships between movement dynamics and EMG signals from left and right splenius muscles. These experimental results are a base from which modeling studies can be performed to explicate the neurological control strategies used in the performance of this class of movements.

Journal Article↗

Refractive astigmatism acts predominantly as a source of high spatial frequency image distortion: the associated lineal distortions can be overcome by using a low pass spatial filter!

PURPOSE: Surprisingly, an important characteristic of astigmatism has been overlooked by ophthalmic and clinical scientists. Apparently, refractive astigmatism is due largely to a form of high spatial frequency image distortion. METHODS: Characteristic astigmatic image distortion can be minimized or eliminated by using a low-pass spatial filter (here, a ground glass plate was employed for this purpose). The ground glass is placed a short distance in front of a visual acuity chart, or it may be used with other tests, such as vernier acuity. RESULTS: This test has been performed by us on large numbers of patients and test subjects. A clinician can try this test for himself/herself. Place a +2.00 D.C. (any axis) lens in front of the eye; the usual distortions will be observed. Locate the ground glass plate as described. The usual distortions associated with the conoid of Stürm will not be visible or will be virtually eliminated, although some image blur will remain. CONCLUSIONS: This technique has significance, e.g., in visual screening programs in developing nations, or in assessing patients with media disorders prior to ophthalmic surgery.

Astigmatism↗