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Biomedical subjects

V Lakshminarayanan

Publications and source records attributed to V Lakshminarayanan.

At least 55 records · Page 3Linked to original sources
PubMed1993

Optics of phakic, pseudophakic, and aphakic eyes: effects on the Stiles-Crawford (SCE I) function.

In many experimental situations one has to work with suitable optical corrections for ocular elements which have been eliminated (lens in aphakia, for example). Analysis of the optics of the total system (eye plus correction and other optical elements) shows substantial changes in the positions of the cardinal points. These changes are meaningful and must be taken into account in subsequent analysis. We discuss the pertinent optical considerations and show as an example the results of measurements of the Stiles-Crawford effect of the first kind in an aphakic subject with spectacle and contact lens correction.

Aphakia↗
PubMed1992

Spontaneous symmetry breaking and the onset of chaos in a muscle model.

The Hill length-tension curve of a muscle fibre is not linear. This had led us to investigate the behaviour of a model muscle sarcomere. The muscle is modelled as an oscillator of mass m subject to a nonlinear restoring force, a periodic external driving force and friction. We have found that this simple, idealized model exhibits spontaneous symmetry breaking and transition to chaos via a period doubling sequence. This result suggests that the nonlinearity in the length-tension curve of a muscle fibre could be responsible for irregular temporal behaviour and muscle tremor.

Animals↗
PubMed1992

Variation of the hyperacuity gap function with age.

Responses to hyperacuity stimuli are processed in quite a different manner by the central nervous system than many other stimuli such as resolution targets or increment threshold stimuli. With increased attention being paid to visual response in aging individuals, it is important to study how these response paradigms are affected by age. In this analysis, otherwise normal observers 20 to 85 years of age were studied. The hyperacuity gap test was used. As defined, this is a vernier test using a two-point test array. This particular format was chosen because the resultant data are less distorted by image blur, scatter, and astigmatism than other designs we have studied. The gap or feature separation between the two small targets (which were aligned vertically) was increased logarithmically using octave steps and the hyperacuity threshold (setting variance) was measured for each step. No systematic variation of vernier hyperacuity threshold was found with increasing age within the range of ages or gaps tested. This is important because it can serve as a valuable control and reference for other clinical studies of aging.

Adult↗
PubMed1991

Anomalous kinetic visual fields found in family members of patients with a confirmed diagnosis of Gilles de la Tourette syndrome.

Three visual manifestations of Gilles de la Tourette syndrome (TS), a neuropsychiatric disorder, have been previously reported. In this paper we report anomalies in the measured kinetic paracentral visual field of TS patients and their family members. We found that 96% of TS patients exhibited paracentral kinetic visual field defects (nasal and temporal steps, enlargement, "ringing," and/or baring of the blind spot). Ninety-three percent of fathers of TS children and, surprisingly, about 80% of mothers exhibit these characteristic visual field anomalies. Sample data and examples of family studies are reported.

Adolescent↗
PubMed1991

Quantification of metamorphopsia using hyperacuity techniques.

We have developed a new technique for quantification of metamorphopsia using a simplified and modified Amsler grid. Furthermore, the technique used is a bisection task, a form of hyperacuity determination. This allows for very fine assessments of metamorphopsia even in the presence of cataracts.

Aged↗
PubMed1990

Discrimination of relative spatial position.

Subjects can accurately discriminate small changes in the relative position of features within a pattern. Simple patterns (intersected line segments) can undergo magnification and a variety of transformations without significantly affecting the discrimination thresholds. Features to be localized and compared need not be similar. We suggest that such relative position discriminations could support complex object identification.

Discrimination, Psychological↗
PubMed1990

Effect of bleaching on the width and index of refraction of goldfish rod and cone outer segment fragments.

Data on goldfish rod and cone fragments were obtained before and after a strong bleach by using a Zeiss Jamin-Lebedeff infrared interference microscope and computer image processing techniques. The receptor fragments were fractured in the inner segment and were immersed in goldfish aqueous humor medium. On bleaching we found that: (1) there is a small increase in rod diameter. This effect is of the same magnitude reported earlier in Rana pipiens outer segments (Vision Res 1973; 13:171). (2) There is an inferred decrease in rod refractive index. (3) There is a decrease in cone width. (4) There is a slight increase in inferred cone refractive index. These data are presented.

Animals↗
PubMed1990

Dopamine and myopia.

Dopamine may play a role in form-deprivation myopia in chickens. Anomalies of the dopaminergic system are believed to be responsible for manifestations of symptoms in Tourette Syndrome (TS), a neuropsychiatric disorder. Visual anomalies have been identified in TS. In this paper, refractive error in people suffering from TS is compared with available population studies. Refractive errors in TS are found to be similar to those in the normal population.

Adult↗
PubMed1989

Visual field defects detected in patients with Gilles de la Tourette syndrome: preliminary report.

The presence of visual field anomalies was measured using Goldmann kinetic perimetry in twelve patients, age 7 to 39 with Gilles de la Tourette syndrome. Refraction to the cupola was carefully controlled. The visual acuity of the group was good to excellent. Visual field alterations were prechiasmal, generally non-symmetric, and best described as arcuate defects, steps, baring of the blind spot and enlargement of the blind spot. Central fields were most commonly affected, i.e., I/2e to I/1B isopters. There was no evidence of glaucoma in any of the patients although two patients exhibited keratoconus and another one manifested moderate to high astigmatism. Visual involvement other than ocular and lid tics have not been reported in Tourette syndrome. This research represents clear evidence of additional physical components in this condition. Automated visual field measurements are not recommended in this population because of the presence of non-predictable tic and vocal behavior (both may result in head/eye movements). Suppression of tic behavior can be very fatiguing. (Eight of twelve of the patients reported exhibited signs of marked fatigue during testing.)

Adolescent↗
PubMed1989

Optical matrices of lenticular polyindicial schematic eyes.

The optical matrices for modified schematic eyes are derived. The primary modification is to replace the usual isoindicial or bi-indicial crystalline lens with a polyindicial lens so as to more closely approximate the living human lens. Further modifications are made to simulate the accommodated state. The use of optical matrices to solve an optometric problem is demonstrated.

Accommodation, Ocular↗
PubMed1988

Measurement of metamorphopsia in the presence of ocular media opacities.

Opacities in the cornea, crystalline lens, and vitreous may make conventional measurements of retinal/visual function of little value. Here, we present two psychophysical hyperacuity tests that are designed to detect and quantify retinal distortions even in the presence of substantial opacities. One test makes use of a two-dot vernier display in which directional bias as well as vernier acuity can be estimated. The second test is a multi-dot hyperacuity bisection task, which resembles a simplified Amsler grid test. By varying the spatial parameters of these stimuli, metamorphopsia may be quantified. The method is applicable both in clear and occluded ocular media.

Adult↗
PubMed1988

Changes in accommodation with age: static and dynamic.

Accommodative amplitude decreases with age, not with aging. The decrease is largely completed by age 40 years; only minor residual accommodation is present in most subjects after the mid-40s. Dynamical measurements show the accommodative response of subjects over 30 years of age to be significantly slowed (time constants of accommodation increases). Accommodation amplitude is less than 3 D by 30 years of age. Thus prepresbyopia is a sign of continual development, not of deterioration of the accommodative mechanism. Accommodation, or the change of clear vision with change in lens power, has been studied by many distinguished scientists including Descartes and Thomas Young. Helmholtz's "Theory of Accommodation" is a dual, indirect, active theory. There are both lenticular, including lens and capsule, and also extralenticular mechanisms, comprised of the zonule of Zinn or suspensory ciliary ligament and the ciliary muscle itself. The ciliary muscle does not act directly on the lens but indirectly through its action on the zonule of Zinn. Active contraction of the ciliary muscle, a unified muscle, produces accommodation; relaxation of the ciliary muscle permits relaxation of accommodation.

Accommodation, Ocular↗
PubMed1987

Effect of monocular light exclusion on the Stiles-Crawford function.

Contrary to previously published studies, monocular light exclusion did not alter the shape of the Stiles-Crawford function in a substantial manner in four subjects who were patched in this laboratory for one full week. In order to rule out methodological differences, an experimenter from each of the two sets of experiments (current and prior) patched one eye for 1 week, then tested each other. For one subject, there was little effect of patching. For the other, patching had a measurable effect, but it was different from that originally reported. However, the much larger, symmetrical broadening of the Stiles-Crawford function reported in earlier studies was not replicated. A testable working hypothesis to explain the earlier results is discussed.

Female↗
PubMed1987

Comparison of two fast quantitative methods for evaluating the Stiles-Crawford function.

Stiles-Crawford (SCE) functions are determined using an increment threshold procedure. The customary technique requires considerable time to obtain a full SCE function and in many situations, both clinical and experimental, it is imperative that the SCE function be evaluated at many retinal loci in as short a time as possible. We have been using two different variants of the standard method, one requiring a very limited number of threshold settings at five fixed entry points in the entrance pupil (5-point method) and in the other, thresholds are determined at only three preselected entry points (3-point method). The time required to obtain a complete SCE function is the order of 5 to 8 min using either method. Comparison and statistical evaluation of the techniques are presented.

Evaluation Studies as Topic↗
PubMed1987

Initial field and energy flux in absorbing optical waveguides. I. Theoretical formalism.

An exact formulation of the electromagnetic field striking an optical waveguide is presented and compared with the decomposition relationship used in the literature. The expression for the critical angle is derived as a natural consequence of this formulation. Equations for the total fraction of power confined within a waveguide are derived and analyzed for the special case of absorbing waveguides. An explicit expression is derived for the fraction of energy confined within a waveguide supporting two sets of modes.

Humans↗
PubMed1987

Initial field and energy flux in absorbing optical waveguides. II. Implications.

We present here numerical estimates of the density and flux of energy based on physical parameters associated with the absorption properties of certain types of absorbing optical waveguides. These results are based on a theoretical formalism established previously for the initial field incident upon the entrance pupil of an absorbing optical waveguide. Based on these results, the mechanisms of confined energy transmission and possible cross talk between neighboring waveguides are discussed. Some comments on the behavior of Bessel functions with complex arguments are also included in the discussion.

Mathematics↗