Fifty-five patients with fixed drug eruption were investigated to determine the drug(s) causing the reaction. History, classic clinical features of well circumscribed erythema, edema and violaceous pigmentation, and the recurrence of the eruptions on the same sites on readministering drug were used as diagnostic criteria. This was confirmed by a provocative test. Sulfonamides and analgesics either alone or in combination were the most common causes of reaction.

Adolescent↗

PubMedDate not supplied

Significance of histopathological classification in leprosy.

A retrospective blind study was carried out on 2640 patients of leprosy to correlate the histopathological and clinical classification of leprosy using the criteria laid down by Ridley and Jopling. There was complete agreement between histopathological and clinical classification in 81.8% of the cases, with one step deviation in 5.1% of the cases. Histopathological diagnosis of indeterminate leprosy in high percentage (15.9%) as against 3.3% of indeterminate leprosy clinically in our series was an interesting feature. Type-wise correlation between histopathological with clinical classification was very high, it being the highest in LL (98%) followed by TT (97%), BT, BB and BL (95%, 89% and 87% respectively).

Adolescent↗

PubMedDate not supplied

Single dose ROM therapy in Goa.

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Adolescent↗

PubMedDate not supplied

The age of onset of leprosy.

The age of onset was determined in 1,053 consecutive patients having different types of leprosy. There were 675 males and 378 females. The majority had onset of the disease between ages 20 and 39, although all age groups were affected. The age of onset was significantly related to the type of leprosy; the mean was lowest in tuberculoid, highest in neuritic, while in borderline and lepromatous it was in between. The comparison of reports of the age of onset from India and elsewhere suggest that this varies in different regions with the country, and from country to country.

Adolescent↗

PubMedDate not supplied

Correlation between clinical and histopathologic classification in leprosy.

A detailed histopathologic study, utilizing hematoxylin and eosin stain, was done in 95 fresh uncomplicated cases of leprosy. The microscopic features were classified according to Ridley's (1974) definition, while the clinical grouping was done using the criteria of Ridley and Jopling (1962). The disparity between them on comparison was explicit. In one third of the cases the two were in consonance with each other. In many there was a shift of one step either towards the tuberculoid or lepromatous end of the spectrum. The remaining were classified as indeterminate because of early histopathologic changes. This disparity was expected because the parameters used for the histopathologic classification were precise and also took into account the immunologic aspect. The histologic definitions seem practical and may prove useful in assessment of the status of the disease with or without treatment.

Humans↗

PubMedDate not supplied

The prevalence and pattern of leprosy in a school survey.

The prevalence of leprosy in a school survey conducted in Panaji, India was found to be 5.3 per 1,000 with males predominating. The majority of patients had a single lesion on exposed parts of the body showing the clinical characteristics of tuberculoid leprosy. However, clinical features of indeterminate leprosy were seen in two patients and borderline tuberculoid in a single case. On the other hand, histopathologically, the majority of the patients were classified as having borderline tuberculoid or indeterminate leprosy. A disparity between the clinical and histopathologic diagnosis was evident. This observation emphasizes the importance of studying both the clinical and histopathologic features in deciding the precise status of a patient in the leprosy spectrum.

Adolescent↗

PubMedDate not supplied

Dapsone syndrome in Goa.

Daspone syndrome was noted within six weeks of starting treatment in 1.3% of about 700 leprosy patients on MDT reporting to the skin department of Goa Medical College. Skin rash, photosensitivity, fever, lymphadenopathy, sore throat, hepatosplenomegaly, abnormal liver function tests and raised reticulocyte count were consistent features in all the patients. Other drugs, infectious mononucleosis and viral exanthemata were considered in differential diagnosis. Withdrawal of dapsone and administration of prednisolone controlled the condition within three to four weeks in majority of the patients. One patient died of ischemic heart disease unrelated to dapsone syndrome.

Adult↗