Search PubMed⌕ Search

Biomedical subjects

V Kliment

Publications and source records attributed to V Kliment.

At least 37 records · Page 2Linked to original sources
PubMed1980

Aerosol deposition in the respiratory tract of the rat. Experimental results and mathematical modelling.

The deposition fraction in the respiratory tract of rats were determined experimentally using aerosol 85Srl2 in saline. The dimensions of the particles [MMD 1.63 /+- /+- 0.47 micron, Sg = 1.29] were measured by two independent methods. Rats weighing 200 g were exposed for a period of 60 min [t] in the inhalation apparatus PIANO 3 with a generator according to Lauterbach. From the volume activity [A] of 3 - 11 Bq/litre air a depot of 35-129 kBq was formed in the animals. Spirometric values measured with a modified Jäger ergospirometer were: V = 178.8 /+- 42.9 ml, VT = = 1.18 /+- 0.24 ml. f = 163.1 /+- 28.1 cycles/min. The total amount inhaled [Q] was calculated [Q = V.A.t], the deposited amount [D] was measured by a whole body counter. THe mean deposition fraction was 0.570 /+- 0.052 and was not related either to exposure time or to aerosol activity. In view of the broad validity of the conclusions for aerosols of round-shaped particles, the mean deposition fraction was determined with the help of a mathematical model according to Landahl. The theoretical values amounted to 0.609 [from 0.522 to 0.686]. The good agreement between the mean deposition fractions estimated by two independent methods indicates that on the basis of the probability theory and dimensional analysis, the mathematical model can also be used in humans for simulation deposition as one of the basis foundations for a quantitative evaluation of inhalation risk from any kind of aerosol.

Aerosols↗
PubMed1978

Contribution to the problem of the so-called nonpathogenic amoebae in the intestine of man.

Among 10,418 patients of a Prague hospital, a plain infection with intestinal parasitic protozoans was identified in 1,319 persons (12.7%). Of these, 3.5% were infested with Giardia intestinalis, 0.3% with Entamoeba histolytica forma minuta, 5.7% with Endolimax nana. We evaluated the frequency of findings of protozoans in various clinical diagnoses. A statistically significant increase in frequency was recorded for E. nana in diagnoses of eosinophilia, giardiasis, amoebiasis and helminthiasis. A slight increase above the average was found for Entamoeba coli in diagnoses of giardiasis and helminthiasis. Most cases of infection with Entamoeba histolytica were associated with a stay abroad. No increase in the frequency of these protozoans was recorded for patients with diarrhea. An analysis of the results indicated that a nonpathogenic amoeba might participate in the origin of intestinal disorders in man.

Adult↗
PubMed1978

The effect of lactation on thyroid activity of women.

The study comprised 12 lactating (L) women, 26 women who interruped the lactating during study (IL) and 6 women failing to lactate (NL). All women gave birth to normal fullterm infants after uneventfull pregnancy and vaginal delivery. Sampling was done during the 2nd day and 10th week after parturition. Lactating women showed more pronounced decrease of thyroxine, decreased thyroxine: triiodothyronine ratio and increased TSH level during the 10th week after parturition in comparison to IL group. The women on NL group showed similar changes as L women, but without increased level of TSH in comparison to IL ones. Results suggest the effect of lactation on the thyroid activity. This effect could be due to the loss of iodine and thyroid hormones to the milk.

Adolescent↗