Search PubMed⌕ Search

Biomedical subjects

V Kambic

Publications and source records attributed to V Kambic.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Laryngeal mucosal changes experimentally produced by endogenous and exogenous factors in mice (author's transl)].

Experimentally an attempt was made to demonstrate the effects of exogenous factors on the hormonally altered laryngeal mucosa of mice. Albany mice were divided into 4 groups of 8. In the first group of males, testosterone was injected daily; in the second group of males, no testosterone was given; in the third group of females with previously removed ovaries, testosterone was given daily; and, in the fourth group of females, no testosterone was given. All 4 groups were exposed to cigarette smoke for one hour daily for six weeks. Histopathological examination of the mucosa showed that the larynx can be considered a "target" organ for male hormones and that exogenous factors produce changes that lead to malignancy.

Animals↗
PubMed1975

[Intubation microtraumatic lesions of the larynx (author's transl)].

Laryngeal microtrauma and seeding of laryngeal malignancy to the lower respiratory tract after short-term intubation is reported. These findings have been confirmed by cytology of smears taken from the endotracheal tubes used on 40 patients. Dysphonia without macroscopically visible laryngeal changes is caused by microtraumatic lesions. The authors advise very gentle intubation to avoid such consequences. Dissemination of infection and malignancy remains unsolved.

Cytodiagnosis↗
PubMedDate not supplied

The role of testosterone in laryngeal carcinogenesis.

Testosterone levels in the plasma of 25 women and 25 men with carcinoma of the larynx and of 15 women and 15 men with hyperplastic aberrations in the laryngeal mucosa were determined to evaluate the etiologic relation between hyperplastic aberrations in the laryngeal mucosa (including cancer) and the male sex hormones. Patients with laryngeal cancer showed statistically significant increases in plasma testosterone levels compared with the control group. No statistically significant differences were found in plasma testosterone levels or in the testosterone/estradiol index between patients with hyperplastic aberrations of the laryngeal mucosa (including precancerous conditions) and the control subjects. The authors believe that greater attention should be paid to endogenous factors, particularly the male sex hormones, in further studies of the etiology of laryngeal carcinoma.

Adult↗
PubMedDate not supplied

Epithelialized microvascular iliac crest flap for reconstruction of subglottic and upper tracheal stenosis: a preliminary report.

A new method for the management of laryngotracheal stenosis using an epithelialized microvascular iliac crest flap is described. This flap offers firm support to the frontal wall, an inner epithelial lining, and is well vascularized. The operation must be carried out in two sessions: skin grafting the flap and transfer with interposition of the flap. In the reconstruction procedure, the otolaryngologist and an experienced microvascular surgeon should cooperate. The method is suitable particularly for solving severe stenosis of the cricoid region and of the upper part of the trachea.

Epithelium↗
PubMedDate not supplied

Significance of keratosis and dyskeratosis for classifying hyperplastic aberrations of laryngeal mucosa.

Retrospective study of 325 tissue samples of hyperplastic aberrations of the laryngeal mucosa by means of light and electron microscopy and immunohistochemical methods has demonstrated that superficial keratinization is not important for determining changes into precancerosis or "risky epithelium" or even for the progress from hyperplastic aberrations to carcinoma. The degree of keratinization of the epithelial surface in all three forms of hyperplastic aberrations is almost the same. In grouping the hyperplastic aberrations into "precanceroses" or "risky epithelium," the following morphologic changes have to be considered as extremely important factors: the occurrence of dyskeratotic cells, the basalification of the epithelium, and the response of the organism in the form of infiltration of immunocompetent cells in the subepithelial stroma.

Adult↗
PubMedDate not supplied

Local immune response in hyperplastic lesions of the larynx.

A retrospective morphologic and immunohistochemical study of 25 benign and 5 malignant laryngeal hyperplastic lesions was performed concerning a local immune response which might be characteristic and of prognostic value for each particular group of these alterations, using Kambic's classification, especially for precancerous and cancerous lesions. On paraffin and frozen sections, 7 monoclonal antibodies against various leukocytic antigens were used. CD43 and CD45RO T lymphocytes were the predominant cells in the infiltrates, and their frequency increased according to the degree of hyperplastic lesions. Next in frequency were CD4 cells, and a predominance of CD4 over CD8 cells was an obvious finding. The infiltration of CD68-, CD57-, and CD20-positive cells was generally weak. The intensity and composition of the local reaction in all cases of atypical hyperplasias was nearly identical, regardless of their subsequent behaviour. No apparent cytotoxic effects on the epithelial cells, either in precancerous or in cancerous lesions, were observed. Thus, the immunocompetent cells in the epithelial and stromal tissue are most likely not an effective defense in preventing hyperplastic lesions from becoming malignant. It seems that laryngeal hyperplastic lesions do not provoke an essential defense immune response, but the present local inflammatory reaction might be a constituent part of etiologically different inflammations which may lead to unfavorable lesions.

Adult↗
PubMedDate not supplied

The influence of cigarette smoke on the pharyngeal mucosa.

The influence of cigarette smoke on the pharyngeal mucosa was investigated in a clinical study and in an experiment on animals. Histologic reports were evaluated according to the Kambic-Lenart classification of hyperplastic aberrations of the throat mucosa. A close dependence of the degree of hyperplasia and the number of cigarettes smoked was revealed. The more cigarettes the patients smoked every day, the more evident were changes on the mucosa, more clearly manifested in male than in female smokers. It was observed that the changes related to the hyperplasia atypica were more evident the longer the patients smoked. They were also more intense the younger the smokers were when they started smoking. In the experiment on animals, a number of factors with additionally noxious influence on the pharyngeal mucosa were excluded. A great interdependence was observed between the number of daily inhaled cigaretes and the changes on the pharyngeal mucosa.

Adult↗