Search PubMed⌕ Search

Biomedical subjects

V Kambic

Publications and source records attributed to V Kambic.

At least 37 records · Page 2Linked to original sources
PubMed1989

Alterations in the laryngeal mucosa after exposure to asbestos.

The laryngeal mucosa of 195 workers in an asbestos cement factory (Salonit Anhovo, Yugoslavia) and in a control group was examined. The factory manufactures asbestos cement products containing about 13% of asbestos (8% amosite, 12% crocidolite, and 80% chrysotile) of different provenance. Alterations in the laryngeal mucosa were more frequent in the factory workers than in the control group. The changes, mostly consistent with chronic laryngitis, were closely related to the degree of workplace pollution and less so to the duration of employment Ten workers exhibiting the most severe clinical changes underwent biopsy, the results of which showed histomorphological changes characteristic of hyperplastic chronic laryngitis. Four tissue specimens were examined also by scanning electron microscopy and in three of them asbestos fibres were found on the epithelial surface. No case of laryngeal carcinoma was identified. On the basis of our results it is thought that asbestos related changes of the larynx should receive more attention and that the use of the term "laryngeal asbestosis" is justified. The clinical picture is non-specific but in view of their frequency such changes should be considered a consequence of exposure to asbestos.

Adult↗
PubMed1989

[Anatomical markers of Reinke's space and the etiopathogenesis of Reinke edema].

On the basis of histological examination of normal human larynges, the authors have defined the anatomical and histological features of Reinke's space. It is sharply demarcated by dense fibrous tissue in the anterior commissure, along the vocal process of the arytenoid and beneath the free margin of the vocal cord. The upper limit is not always sharply demarcated, and on the upper surface Reinke's space varies considerably in size. It may include a half of the upper surface of the vocal cord, reaching usually to the bottom of the laryngeal ventricle and occasionally extending to include also the inferior surface of the ventricular fold. The authors suggest that the upper boundary of Reinke's space is functional. On the basis of the morphologic structure of Reinke's space a hypothesis of aetiopathogenesis of Reinke's oedema was set up. The patient's attempt to compensate the hoarseness by the use of the false vocal cords forces the fluid within Reinke's space towards the free edge of the vocal cord.

Capillaries↗
PubMed1989

[The significance of psychological factors in the early diagnosis of laryngeal and hypopharyngeal tumors].

The clinical course of malignant disease is influenced by the patient's personality and his attitude to disease and to treatment. The authors interviewed 150 patients scheduled to undergo microlaryngoscopy, indicated to identify pathologic aberrations of the larynx and pharynx. - Analysis of the data showed that fear of cancer was less common in patients found to have a carcinoma than in those with benign aberrations. Patients with cancer were more inclined to postpone medical examination and showed a significantly greater degree of denial of their symptoms. A positive family history of malignant disease was significantly more frequent in patients who had marked fear of cancer than in those who did not have such fears. Female patients fearing cancer had a significantly greater frequency of neurotic symptoms, compared to females who had no fear. For nearly a half of smokers (45%) the proposed microlaryngoscopy provided a motive to give up smoking.

Adult↗
PubMed1986

A simple and inexpensive method for laryngeal photography with the operating microscope.

After a brief review of the history of laryngeal photography, a simple and inexpensive method as used at the ENT Clinic of Ljubljana is described. The equipment consists of a standard 35 mm Olympus OM-1 camera attached to the Olympus of OME-J operating microscope and an Olympus T-32 flash unit connected via a large bore flexible light cable to a specially designed laryngoscope. With the equipment described excellent photographs can be obtained even in inexperienced hands without interference with endoscopic procedures.

Humans↗
PubMed1985

[Testosterone--an etiological factor in the development of laryngeal carcinoma?].

To evaluate the etiological connection between the development of hyperplastic lesions of the laryngeal mucosa (including cancer) and the male sex hormones, the authors determined the level of testosterone in the serum of patients with cancer of the larynx (25 women and 25 men) and patients with hyperplastic lesions of the mucous membrane of the larynx (15 women and 15 men). In patients who suffered from cancer of the larynx the serum level of testosterone was significantly increased compared to the control group. In the patients who had hyperplastic lesions (including precancerous lesions) of the laryngeal mucosa the differences in the concentration of the serum testosterone were not statistically significant from the control group. The same was also true of the testosterone-estradiol index. The results of the study do not help to explain the success of hormonal therapy for hyperplastic lesions of the laryngeal mucosa. The authors consider that endogenous factors, especially the male sex hormones, should be taken more into account, alongside exogenous factors, in the genesis of laryngeal cancer.

Adult↗
PubMed1984

Topographic anatomy of the external branch of the superior laryngeal nerve. Its importance in head and neck surgery.

The authors have studied the anatomy of the external branch of the superior laryngeal nerve in its entirety on 40 fresh cadavers, and they have drawn the following conclusions: the nerve ramifies from the vagus immediately below the nodose ganglion or in the ganglion itself. The nerve splits into two branches approximately 1.5 cm below the ganglion nodosum. In four cases, both branches originated from the vagus itself. In one case, anastomosis of the external branch of the superior laryngeal nerve with the recurrent nerve was found. The external branch of the superior laryngeal nerve is not usually severed at supraglottic laryngectomy but the nerve is at risk during neck dissections, resection of Zenker's diverticula and thyroidectomy. An accurate knowledge of its course should reduce the incidence of injury to the branches of the superior laryngeal nerve during surgery.

Humans↗
PubMed1984

Acid posterior laryngitis. Aetiology, histology, diagnosis and treatment.

The authors have treated 44 patients with posterior chronic acid laryngitis. Biopsy was performed in all patients. Characteristic changes typical of the hyper-regenerative or atrophic phase of reflux oesophagitis were identified in all specimens. Gastric hypersecretion was proven in all but two patients. The aetiologic factors of acid posterior laryngitis are gastro-oesophageal reflux, with friction of both vocal processes during phonation and vocal abuse. The preferred therapy is removal of circumscribed lesions with a suitable medical regimen.

Adult↗
PubMed1984

Nasopharyngeal rhabdomyoma. Report of case (light and electron microscopic studies) and review of the literature.

Rhabdomyoma is an extremely rare benign tumor originating from the skeletal or cardiac muscle cells. Only 87 cases of rhabdomyoma have been reported to date, 70% occurring in the head and neck areas. The authors present the fourth case of rhabdomyoma of the nasopharynx. The tumor appeared in an 18 year old woman with hypacusis. Examination of the epipharynx showed a 2 x 1,5 cm tumor, extending from torus tubarius down to the soft palate. Light microscopy disclosed areas and islands of polymorphous large cells with abundant eosinophilic cytoplasm. Cross striations were focally visible with special PTAH staining. Electron microscopy revealed parallel and haphazardly arranged fibrillar bands (myofibrils) with irregularly and periodically arranged densities corresponding to Z lines. The pecularities of our case were abundant cystically dilated rough endoplasmatic reticulum and the absence of cytoplasmatic glycogen.

Adolescent↗
PubMed1982

Warty dyskeratoma of the vocal cord. First reported case.

Warty dyskeratoma is a tiny, nodular lesion with a characteristic histologic picture that resembles that of Darier's disease. Until now, these changes have been described only on the skin and the mucosa of the oral cavity. To our knowledge, our case includes the first description of this lesion on the vocal cord. This study presents clinical and histologic features in detail, dealing also with the differential diagnosis, which is very important for distinguishing the warty dyskeratoma from the squamous cell carcinoma.

Carcinoma, Squamous Cell↗
PubMed1981

[Immunological aspects of infantile tonsilloadenoidectomy (T&A) (author's transl)].

Authors studying the frequency of tonsillectomy and adenoidectomy (T&A) have found three times more operations in their country than in the U.S.A. The indication for operation is given by the general practitioner and pediatrician without previous sufficiently long treatment of the underlying disease. The cytological analyses of tonsillar tissues showed a highly active transformation and differentiation of immunologically competent cells and the phagocytes. A close negative correlation between the percentage of the immunologically competent cells and a close positive correlation between the percentage of phagocytes and the frequency of tonsillitis was calculated. The volume, consistency and adhesion of tonsils do not block the highly active transformation and differentiation of the lymphocytes in the tonsillar tissue. The percentage of T-lymphocytes was found to be significantly higher in hypertrophic tonsils, representing a mean value of the percentage of T-lymphocytes in the tonsils of 31 children. Furthermore, in the tonsils with adhesions there was a statistically significant higher percentage of B lymphocytes then in the tonsils which were free from adhesions.

Adenoidectomy↗
PubMed1978

Intubation lesions of the larynx.

One thousand patients were examined immediately after extubation of the trachea at the end of anaesthesia. Severe lesions of the larynx were detected in 62 patients (6.2%). The lesions encountered included haematoma, laceration of the mucous membrane, laceration of the muscle and subluxation of the arytenoid cartilage. In spite of early diagnosis and adequate treatment, it was not possible to avoid an effect on the voice in nine patients.

Hematoma↗
PubMed1978

Difficulties in management of vocal cord precancerous lesions.

Hyperplastic aberrations are differently classified and the term of precancerosis diversely interpreted; therefore, it is extremely difficult to evaluate the effectiveness of particular therapeutic methods. A standardized classication would enable an objective assessment of the treatment for precanceroses. Our own conception of the histologic patterns in precanceroses is presented. In the period 1960-1975, a total of 2,700 biopsies were performed in patients with hyperplastic aberrations in the vocal cord mucosa. In 133 patients, histology revealed precancerosis. In the patients who had received medical therapy, no improvement was obtained; on the contrary, in 16 patients the process became malignant. Among the patients who had undergone de-epithelialization (61), 44 were cured. After the de-epithelialization, no precancerous case turned malignant. De-epithelialization has been shown to be the procedure of choice for the treatment of precanceroses of the vocal cord.

Epithelium↗
PubMed1977

[Clinical and functional results in tracheotomized children (author's transl)].

Twenty-nine children between the ages of 2-months- and 7-years-old were tracheotomized at the Department of Otorhinolaryngology, Med. Centre, Ljubljana, from 1965 to 1974. Decannulation was performed 6 days postoperatively, on the average. Complications of tracheotomy were observed in 2 children only; one child died on the 7. postoperative day to basic disease. Twenty tracheotomized children were subject to follow-up examination consisting of history taking, clinical, otorhinolaryngologic, anthropometric and allergologic examinations. In eleven school children spirography and bodyplethysmographie for a possible tracheostenosis was performed. The calculated FEV1/FIV1 quotient, e.g. statistically significant values higher than 1.0 revealed tracheostenosis in two patients.

Adolescent↗
PubMed1977

H incision--method of choice for radical neck dissection.

To prevent skin necrosis, fistula formation and rupture of the carotid arteries after RND, vascularization of the skin of the neck has been considered. The neck vessels (in cadavers) were injected with coloured media and specimens of the skin were cleared (Spalteholz method). The arteries supplying the skin of the neck followed in general an obviously longitudinal course: one group of cutaneous arteries descending from the branches of the external carotid; another group ascending from the branches of the subclavian artery. The upper and lower groups of arteries joined approximately in the middle of the neck. The density of cutaneous arteries in the neck was much poorer than in the facial skin. On the basis of these anatomic data, an incision for RND has been proposed in the form of an H or three-quarter H, in which the transverse line of the incision follows the least vascularized skin region of the neck, without interrupting the great skin vessels. Incisions in the form of a Z or a double Y, OR McFee's incision, do not fulfil this requirement. The authors also report the results of wound healing after RND in 184 patients who were operated in the period fron 1968 to 1975 at the E. N. T. clinic of Ljubljana, where the H incision or one of its modifications was used.

Humans↗