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Biomedical subjects

V K Gupta

Publications and source records attributed to V K Gupta.

At least 145 records · Page 8Linked to original sources
PubMed1984

Spectrophotometric determination of vanadium in complex materials using N-m-TMBHA and thiocyanate.

Vanadium(V) reacts with N-m-Tolyl-p-methoxy benzohydroxamic acid to form 1:2 (metal to ligand) complex containing a basic V = O group and an acidic V-OH group, which forms addition compounds with thiocyanate to give a hyper and bathochromic effect in chloroform. On the basis of this bathochromic effect of thiocyanate a rapid, selective and sensitive method for the spectrophotometric determination of vanadium(V) has been developed. The blue coloured complex of vanadium(V) is extractable in chloroform having absorption maxima at 580 nm and max 7100 +/- 50 1 X mole-1 cm-1. The method is free from interferences of Mo(VI), W(VI), Zr(IV) and has been successfully applied for the analysis of steels and other complex materials.

Chemical Phenomena↗
PubMed1984

Proliferative and stimulatory effects of PGA2 on nucleic acids in the adrenal and kidney of squirrel, Funambulus pennanti.

Effects of exogenous prostaglandin A2 (PGA2) on DNA and RNA contents of the adrenal and renal tissues have been examined histochemically. Loss of DNA from the chromatin was observed in both the tissues; however, cells of the capsular regions showed normal cytochemical reactions. Stimulated reactions for RNA in both the tissues but with topographical differences signify the elevated functional capacity. Results further prove the proliferative nature of PGA2. Irregularities in the endogenous secretion of PGA2 and other hormones thus caused, seems to be responsible for these effects.

Adrenal Glands↗
PubMed1983

E-rosette forming cells (E-RFC) in squamous cell carcinoma of the larynx and laryngopharynx.

The percentages of early and late E-RFC were measured in 25 proven cases of squamous cell carcinoma of the larynx and laryngopharynx. Both counts were depressed significantly in the patients compared to the controls (p less than 0.001). There was also a significant correlation of these counts with the severity of the disease, but there was no correlation between the counts and the duration of the disease.

Carcinoma, Squamous Cell↗
PubMed1983

A study on lipids in the adrenal and kidney of squirrel after prostaglandin A2 treatment.

Prostaglandins have been assigned both physiological and pharmacological properties. Moreover, they have been identified in the renal tissue. Nevertheless, effects of exogenous prostaglandins on different systems are not fully known. Since PGA2 escapes destruction in the lungs, it functions as circulatory hormone. How prostaglandins of A group effect lipid metabolism in renal and adrenal tissues has been studied during this investigation. Qualitative and quantitative studies thus performed showed that PGA2 stimulated lipid activities in both the tissues. Whether they inhibited the transport of lipids away from these tissues or enhanced their biosynthesis is not known at present. However, histochemical studies on neutral lipids and phospholipids show that PGA2 stimulates lipid synthesis in these two issues.

Adrenal Glands↗
PubMed1982

Lipids in the kidney and adrenal of squirrel, Funambulus pennanti, after sex-hormones treatment.

Interference of sex-hormones viz. testosterone and progesterone with adreno-renal lipids have been determined employing histochemical and biochemical parameters. The results show that both the hormones stimulate accumulation of triglycerides and phospholipids in the kidney and adrenal glands. It has been suggested that testosterone and progesterone manipulate an increase in the input of free fatty acids (FFA) causing triglyceride formation and inhibit mitochondrial phosphorylation. Inhibition of esterases has also been proposed as the reason for the accumulation of phospholipids. Over all results have been discussed with special reference to 1. pathological exaggeration by these hormones 2. hormonal carcinogenesis, and 3. protein and carbohydrate metabolism.

Adrenal Glands↗
PubMed1981

Renal vein thrombosis in nephrotic syndrome--a prospective study and review.

The incidence of renal vein thrombosis (RVT) and other thrombo-embolic phenomena was evaluated in 44 unselected patients with nephrotic syndrome. Renal vein thrombosis was demonstrated by selective renal venography in 10 patients and at post-mortem in one. Extension of the thrombus from the renal veins into the inferior vena cava was seen in 3 patients. Evidence of thrombo-embolism elsewhere in the body was seen in the form of thrombophlebitis in the lower extremities in 4 patients (9.1%), pulmonary embolism in 3 (6.8%) and myocardial infarction in one (2.3%). Of the 11 patients with RVT, renal histology showed membranous glomerulonephritis in 3, minimal change nephritis in 5, membrano-proliferative in one and focal and diffuse proliferative glomerulonephritis in one patient each. The characteristics clinical findings such as gross haematuria and flank pain were noted in only 3 patients with RVT. No significant difference could be detected between the plasma fibrinogen, serum cholesterol, beta-lipoprotein, triglycerides and phospholipid concentration of those who showed RVT and the remainder in whom RVT was not demonstrated. The possible mechanisms involved in the pathogenesis of RVT in nephrotic syndrome are discussed.

Adolescent↗
PubMed1980

Pulmonary function in nonsmoking chronic alcoholics.

To our knowledge, this is the first published report to describe pulmonary function in nonsmoking alcoholics who also do not have a history of respiratory illness. This study, in sharp contrast to those that include smokers, shows that pulmonary function, including diffusing capacity, is within normal limits. The "true shunt" noted in all subjects who underwent blood gas studies is probably related to liver disease. Our study also suggests that gas exchange may be impaired even in patients with mild alcoholic liver disease (table 3). When the airway closes prematurely as a result of blood vessel dilatation and/or interstitial pulmonary edema, ventilation decreases. This results in appreciable shunting via portopulmonary and intrapulmonary communications and in a very low ventilation/perfusion ratio of the dependent lung zones. We consider that application of any formula to separate the effects of tobacco from those of alcohol will produce, at best, approximate values.

Adult↗
PubMed1979

Modulation of Chloroplast Fructose-1,6-bisphosphatase Activity by Light.

Inhibitor experiments indicate that light effect mediator(II) which is reductively activated by transfer of electrons from the photosynthetic electron transport system at or beyond ferredoxin, is involved in activation by light of fructose-1,6-bisphosphatase in the pea plant. Activation proceeds optimally when the pH is low and Mg(2+) is 10 millimolar. Modulation by light results in increases in maximal velocity, apparently as a result of changes in enzyme conformation. Pea leaf thylakoids are effective in modulating the activity of glyceraldehyde-3-phosphate dehydrogenase but not of fructose-1,6-bisphosphatase or glucose-6-phosphate dehydrogenase in Kalanchoë stromal extracts. There is apparently species specificity for modulation of some, but not all, of the modulatable enzymes.

Journal Article↗