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Biomedical subjects

V Jayanthi

Publications and source records attributed to V Jayanthi.

At least 109 records · Page 6Linked to original sources

Faecal chymotrypsin assay in tropical and alcoholic chronic pancreatitis.

Faecal chymotrypsin (FCT) levels were estimated in a group of patients with tropical chronic pancreatitis (TCP) and compared with patients with alcoholic chronic pancreatitis (ACP), 'gastrointestinal' controls and 'healthy' subjects. Exocrine pancreatic insufficiency as assessed by low faecal chymotrypsin levels (less than 5.8 mu/g) were present in 85.7 per cent of TPC and 84.6 per cent of ACP patients. Mean FCT levels as well as the distribution of FCT values were similar in TCP and ACP patients and significantly lower than the two control groups (P less than 0.001). There was also no difference with respect to mean FCT levels between subgroups of TCP patients with and without diabetes and those with and without calcification. Faecal chymotrypsin assay is a simple test for diagnosis of chronic pancreatitis in gastroenterological centres in tropical countries.

Alcoholism↗

Oesophageal manometry in noncardiac chest pain.

Chest pain of oesophageal origin is an important differential diagnosis in patients with cardiac chest pain. A preliminary survey of 40 patients with noncardiac chest pain (NCCP) revealed oesophageal motility disorder in 47.5%; achalasia cardia being the most frequent disease (47.3%). 15.8% of these patients with motility disorder had features of progressive systemic sclerosis and another 15.8% had non specific oesophageal motility disorder (variants). Compared to barium swallow, oesophageal manometry was found to be superior in the diagnosis of oesophageal motility disorder.

Adult↗

Budd Chiari syndrome and pericaval filariasis.

A young girl presented with Budd-Chiari syndrome (BCS) with narrowing of the retrohepatic segment of inferior vena cava (VC). Dorsal cavoatrial bypass (DCAB) was unsuccessful due to thrombotic occlusion of the graft. A limited autopsy revealed occlusion of the retrohepatic segment of IVC and the terminal parts of the three major hepatic veins. Caval occlusion was just above the level of the superior hepatic veins, and caused by a transverse fibrous shelf. An adult filarial worm was found amidst pericaval fibrosis. Filariasis should be included as a possible aetiological factor in chronic BCS.

Adolescent↗

Traumatic eventration of diaphragm complicated by mesenteroaxial volvulus of the stomach.

Diaphragmatic disruption is an uncommon consequence of blunt trauma and is often overlooked unless there is a high index of clinical suspicion. A case of eventration of left dome of diaphragm following trauma with mesenteroaxial volvulus of the stomach is presented. Anatomical considerations on levels of diaphragm on chest x-ray has been elaborated.

Adult↗

Betel nut and smoking. Are they both protective in ulcerative colitis? A pilot study.

Two-hundred and twenty-three Asian patients with inflammatory bowel disease were sent a questionnaire about smoking and betel nut chewing habits. The 116 responses from patients with ulcerative colitis were compared with answers from 79 healthy members of the community. Twelve per cent of male patients were currently smokers compared with 31% of healthy controls (chi 2 = 20.9 P < 0.05). No such differences existed between female patients and controls. Thirteen per cent of male patients regularly used betel nut compared with 20% (chi 2 = 3.9 P < 0.05). Both smoking and betel nut chewing appear to reduce the risk of developing ulcerative colitis, although these effects may be linked.

Adult↗

Quality of life after colectomy. A comparison of conventional ileostomy and sphincter saving continent procedures.

The quality of life before and after both ileostomy and continent procedures. Park's pouch with an ileoanal anastomosis a straight ileoural anastomosis and Koch's ileostomy was compared amongst members of the Ileostomy Association. Of 860 patients who were asked to complete questionnaires about aspects of their quality of life, 80% replied. They were all matched for symptoms preoperatively. Fourty-eight had undergone continent procedures. Postoperatively patients with continent procedures had significantly more symptoms. Although the mean frequency of "defaecation" improved in all patients, except those with ileoanal anastomoses, faecal incontinence remained a problem in 26% of those with Park's pouch, 33% with an ileoanal anastomosis and 9% with Koch's ileostomy. Mood improved most in those with either Park's pouch or ileoanal anastomosis. Sexual problems were similar regardless of operative procedure. Our results cast serious doubts on the efficacy of continent procedures.

Adult↗

Diet of South Asians with inflammatory bowel disease.

The diet of South Asian patients with inflammatory bowel disease was studied using a postal questionnaire and compared with controls matched for age and ethnic group. Hindus with Crohn's disease are sweets significantly more often than either healthy controls (chi 2 = 13.0, P < 0.005) or Hindus who had ulcerative colitis (chi 2 = 9.8, P < 0.05). Hindus with ulcerative colitis were significantly less likely to drink milk than their matched controls (chi 2 = 7.4, P < 0.01). Hindu patients were also less likely to use spices and eat flour than controls (chi 2 = 12.5, P < 0.005). No difference was found in the diets of patients belonging to other religious groups and controls. This study again suggests that a high intake of refined carbohydrate is associated with Crohn's disease, while patients with ulcerative colitis have significantly altered their traditional diet.

Adult↗

Bronchogenic cyst presenting as dysphagia.

We report an adult patient who masqueraded as a case of gastroesophageal reflux disease for over 6 years. On close questioning he was found to have severe constricting pain in the retrosternal region and non progressive dysphagia for 6 years. Cineradiography of the oesophagus and CT scan chest revealed a large bronchogenic cyst compressing the oesophagus and the trachea. Excision of the cyst relieved the symptoms.

Adult↗

Is vegetarianism a precipitating factor for gallstones in cirrhotics?

AIM: To study the association of factors such as alcohol, smoking and vegetarianism with presence of gallstones amongst cirrhotics. PATIENTS AND METHODS: Data on alcoholism, smoking and vegetarianism was collected from the case records of 669 cirrhotics with (76) or without gallstones (593) retrospectively. Relative risk for the factors was computed individually and in combination controlling for the effects of alcoholism and smoking on vegetarianism. RESULTS: Alcoholism and smoking were of low relative risk [R.R-1.27 (95% CI 0.82 to 1.96), and 1.02 (95% CI 0.65 to 1.61) respectively] while vegetarianism was associated with high risk for gallstone formation in cirrhotics [R.R 2.74 (95% CI 1.65-4.53)]. Vegetarian men had a relative risk of 3.02 (95% CI 1.75-5.22) irrespective of their alcoholic status. If women were alcoholic the relative risk increased to 7.03 (95% CI 3.26-15.12). Controlling for effects of gender and alcoholism, vegetarian cirrhotics had a 3 times greater risk for gallstone formation [Mantel Haenszel Relative Risk 3.18 (95% CI MHRR 1.82-5.56)]. CONCLUSIONS: Cirrhotic, vegetarian women in South India have a much higher risk for gallstones, if they are alcoholic. Alcoholic men who are vegetarians are at a greater risk for gallstone disease.

Alcoholism↗