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Biomedical subjects

V I Stoliarov

Publications and source records attributed to V I Stoliarov.

At least 37 records · Page 2Linked to original sources
PubMed1991

[The choice of the extent of the surgical intervention in patients with soft tissue sarcomas of the extremities].

The analysis of data on 446 patients with soft tissue malignancies showed overall five-year survival rate to be 48.9%. The extent of tissue to be removed during sparing surgery is specified. In case of intramuscular location of tumor, it is enough to leave a 4-5-cm margin above and below the tumor border, as assessed by palpation. Indications for limb amputation at various levels were developed. Limb-sparing surgery could be employed on a larger scale if advances of modern plastic (skin, bone and vascular) surgery were adopted wider. A complex of rehabilitative measures was developed. Patients undergoing limb amputation need early prosthetics.

Amputation, Surgical↗
PubMed1991

[Metastatic involvement of regional lymph nodes and long-term results of the treatment of patients with cancer of the thoracic part of the esophagus].

The patients who underwent the radical operations for cancer of the thoracic esophagus were subdivided into three groups: group 1--patients with no metastatic involvement of the regional lymph nodes (N0); group 2--with enlarged regional lymph nodes because of their hyperplasia, but without metastatic involvement (NX); group 3--with metastatic involvement of the regional lymph nodes (N1). The best results of 5-year survival after radical operation (50.2%) were noted in patients with a tumor size less than 3 cm, infiltration of only muscular layer, high degree of cancer differentiation, without metastatic involvement of regional lymph nodes. In presence of metastases, the 5-year survival was 6.01%. Discovering at operation the enlarged lymph nodes is a poor prognostic sign, 5-year survival of these patients do not exceed 9%.

Esophageal Neoplasms↗
PubMed1991

[Concentrated irradiation as a stage of multimodal treatment of cancer of the proximal part of the stomach].

The postradiation changes in carcinoma of the proximal part of the stomach were studied in 32 patients: the parenchymal volume (PV), the damage index (DI), and the mitotic index (MI). The controls were 15 cases in which radiotherapy was not applied. Radiotherapy with large fractions (5 Gy 4 times daily) reduced the PV to 27 +/- 0.8 u on average as compared to the controls (77 +/- 1 u) and lowered the MI to 2.3 +/- 0.5% as compared to the controls (8% +/- 1), the DI ranged widely (3-67%). The methods of quantitative morphological study of tumors may be useful in objective evaluation of the efficacy of various schemes of preoperative concentrated irradiation.

Adenocarcinoma↗
PubMed1990

[The prognostic significance of the anatomical forms of esophageal cancer].

Among the great variety of anatomic patterns of esophageal cancer growth, three basic patterns--exophytic, mixed and endophytic--should be distinguished. Anatomic pattern of growth is one of the basic prognostic criteria for tumor stage assessment. This finding is supported by five-year survival evidence for cases of radical surgery: 58.8 +/- 10% with exophytic form, 16.6 +/- 10%--ulcerative infiltrative and 3.3 +/- 6% with diffuse infiltrative pattern of tumor growth.

Esophageal Neoplasms↗
PubMed1989

[Combined treatment of soft tissue sarcoma].

The five-year results of surgical and combined (irradiation + operation) treatment of 451 patients with sarcoma of the soft tissues are analysed with due account for the principal prognostic factors. It is shown that the survival of patients may be prolonged if the operation is supplemented by irradiation. Comparison of three variants of combined treatment showed the advantages of combined treatment with subsequent postoperative irradiation. Radiotherapy does not increase the number of postoperative complications.

Adolescent↗
PubMed1989

[Combined surgery in cancer of the proximal section of the stomach].

The investigation showed combined surgery for cancer of the gastric cardia to be justified from the oncological point of view. Such intervention reaches out to the limit of radical treatment. However, combined surgery should not be performed unless there are substantial indications. Basic indications for excision or resection of an adjacent organ should be gastric tumor extension through organs and tissue or dissemination to the regional lymph nodes which cannot be radically removed unless surgery is performed on adjacent organs.

Cardia↗
PubMed1989

[Effect of ethanol on N-nitrososarcosine ethyl ester-induced carcinogenesis in the esophageal and forestomach mucosa of mongrel rats].

Administration of N-nitrososarcosine ethyl ether (50 mg/kg, per os, every day during 4 months) to rats induced after 8 months multiple tumours (most often papillomas) of oesophagus and forestomach. Total incidence of tumour-bearing animals was 42.4% in oesophagus and 21.2% in forestomach, distribution of tumours being 85.6 and 14.4%, respectively. The combined administration of carcinogen with 40% water solution of ethanol (0.5 ml, per os, every day during 8 months) did not change general incidence and multiplicity of all tumours, but decreased the relative incidence of oesophagus tumours and increased that of forestomach tumours. Possible mechanisms of organotropism shifts are discussed.

Animals↗
PubMed1989

[Effects of thermal burns of the esophagus on carcinogenesis induced by ethyl ethers of N-nitrososarcosine in rats].

The study was concerned with the effect of electro-thermocoagulation burn of the rat gullet on carcinogenesis induced by esophagotropic carcinogen--ethyl ester of N-nitrososarcosine (50 mg/kg, five times a week, four months). Treatment was started on day 15 postburn, and at 8 months tumors of the esophagus occurred in 71.8% including tumors in the burn area (46.8%). Forestomach neoplasms were observed in 15.6%. Animals treated with the carcinogen alone showed a significant decrease in both overall frequency of esophageal tumors (42.4%) and that for the burn area (18.1%) while frequency of forestomach neoplasia remained nearly the same (21.2%). Most tumors were benign papillomas. It was concluded that burn--induced cicatricial changes in the esophageal mucosa predispose to development and growth of tumors of this site.

Animals↗
PubMed1988

[Stimulating effects of 3% acetic acid on the induction of esophageal tumors in rats].

The probe--mediated intragastric injection of 50 mg/kg ethyl ether of N-nitrososarcosine (EENS) 5 times a week for 6 months was followed by the development of multiple tumors in 91.8% of 120 noninbred male rats supplied by a local animal farm: esophagus--85.7%, fore-stomach--73.4% and throat--22.4%. The lesions in the esophagus and the fore-stomach entry were similarly frequent (61.2-75.5%) which was matched by a much lower incidence rate (22.4%) for the remaining parts of the fore-stomach. The combined intragastric injection of 3% acetic acid (0.5 ml thrice a week) for 8 months and EENS for 6 months boosted the total frequency of neoplasms to 100% and resulted in increased multiplicity of tumor--from 9.8--10.7 for EENS alone to 14.5 for EENS + acetic acid. Most lesions occurred in the fore-stomach entry as far as the level of tumor (squamous cell carcinoma and papilloma) development, frequency and relative risk (number of tumors. v. actual number of animals) are concerned. A long--term treatment with 3% acetic acid alone was followed by chronic inflammation of the esophageal mucosa rather than tumor development.

Acetates↗
PubMed1987

[Medical care for patients with cancer of the upper thoracic segment of the esophagus].

Out of 350 hospitalized cases of esophageal carcinoma in the upper thoracic segment, stage III-IV tumors were identified in 82.8%. A retarded seeking of medical advice was chiefly responsible for the advancement of tumors. Radical surgery was performed in 32 (9.1%) patients only. The percentage of radically-treated cases could have been greater, if there had been fewer refusals to operate and to be operated on both on the part of patients and doctors who would object to surgery on the grounds of concomitant pathology or the patient's age. Radiotherapy, used in 197 (72.7%) patients as a sole method of treatment, was followed by remission in 68%.

Aged↗
PubMed1987

[Comparative analysis of clinical data on pigmented villonodular synovitis and sarcoma of the soft tissues of the legs].

Pigmentary villonodular synovitis was isolated in an independent nosological unit in 1941. A comparative analysis of data on 278 patients with soft tissue sarcomas of lower extremities (262 observations) and pigmentary villonodular synovitis (16 observations) is presented. Clinico-historical data, results of instrumental methods of examination evidence the absence of any definite symptoms of these diseases. Findings of punctures are most informative.

Adolescent↗