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Biomedical subjects

V I Skvortsova

Publications and source records attributed to V I Skvortsova.

At least 55 records · Page 3Linked to original sources
PubMed2003

[The influence of the hormones of hypothalamo-pituitary-adrenal, renin-angiotensin, and thyroid hormonal systems on formation of vascular encephalopathy].

The aim of the study was to investigate the concentration changes of free (f) thyroxine (fT4), triiodothyronine (fT3), thyrotrophic hormone (TTH), adrenocorticotrophic hormone (ACTH), aldosterone and renin in the blood plasma of patients with vascular encephalopathy (VE) and to evaluate their influence on formation of chronic blood circulation deficiency. Thirty-nine patients with VE of stages I and II, aged 45-73 years, without current acute or chronic (in exacerbation stage) other somatic diseases have been studied. The results revealed that a different extent of diffuse lesion of brain tissue was accompanied by an own pattern of thyroid homeostasis: 1) significantly higher TTH levels with intact regulatory negative feedback "fT3-TTH" in patients with VE, stage 1; 2) significant TTH concentration decrease, with pronounced suppression of thyroxine conversion to triiodothyronine and interaction disturbance in the "fT3--pituitary gland" system, in patients with VE in stage II. A distinct trend towards plasma cortisol level increase as well as significantly lower active plasma renin levels were found in the patients with VE in stage II comparing to those in stage I. Correlation analysis demonstrated the absence of an interaction between patient's age and hormonal homeostasis state and an extent of vascular stenosis. The data suggest involvement of the hormones of hypothalamopituitary-adrenal, thyroid and renin-angiotensin systems in VE formation thus enabling using of the results of their testing as an additional criterion for estimation of brain diffusive lesion severity.

Adrenocorticotropic Hormone↗
PubMed2002

[Neurotrophic factors and autoantibodies to them as molecular predictors of cerebral dysfunctions].

A complex of clinical and immunochemical studies was made in patients with chronic brain ischemia and ischemic stroke and in neonatal infants with CNS dysfunctions and retarded intrauterine development. Enzyme immunoassay was used to measure the levels of brain proteins with trophic properties--S100b, the major protein myelin, lectins CSL, R1, and the levels of primary and antiidiotypic antibodies to these proteins in the biological fluids of the patients. The findings suggest that the study brain proteins and autoimmune processes against these factors are involved in the mechanisms of the pathogenesis of the diseases in question and they enable changes and variations in the levels of neurotropic factors and their autoantibodies to be considered as predictors of brain ischemia and perinatal cerebral lesions.

Autoantibodies↗
PubMed2002

[Clinico-immunological comparisons in evaluation of interferon system functioning in patients with multiple sclerosis].

In search for rational approach for immunotherapy individualization in patients with multiple sclerosis (MS) assigned to interferon (IFN) treatment, an evaluation of IFN-alpha and IFN-gamma production by peripheral blood leucocytes (PBL) under standard induction and exogenous IFN priming in comparison with clinical characteristics was made. Fifteen patients with MS (6 males and 9 females, aged 25-58 years) with verified diagnosis of MS were examined. IFN production priming allowed to obtain characteristics of IFN system deficiency, which could not be detected by standard induction methods. Correlation between induced and primed PBL. IFN-gamma production and MS severity, duration and course was found. Patients with no PBL blood cells dissociate response to IFN-alpha and IFN-gamma exhibited less neurological deficit than those with associations in response. A use of blood cell sensitivity to exogenous IFN in individualization of MS immunotherapy with IFN-medications is discussed.

Adult↗
PubMed2002

[Principles of early rehabilitation of patients with stroke].

Basing on general pathophysiological data, the main outlines and principles of early rehabilitation of patients with acute disturbance of cerebral blood flow are considered. Clinical ENMG analysis of peripheral neuromuscular apparatus in 32 patients with right- and left-side location of the lesion in acute and early rehabilitation periods of ischemic stroke is presented. Different variants of ENMG interrelations between paretic and intact extremities and their correlations with functional rehabilitation degree are shown. Different sanogenetic mechanisms of movement functions rehabilitation in patients with right- and left-side lesions are hypothesized. The results of early rehabilitation of patients with stroke in neurological clinic of Russian State Medical University (General Municipal Hospital N20) are presented.

Electromyography↗
PubMed2002

[Disrupted circle of Willis and crisis course of arterial hypertension].

Two patients, aged 17 and 55 years, with partly or completely open circle of Willis were examined using cerebral magnetic resonance angiography. A role of anatomical structure of circle of Willis and other anastomotic peculiarities of brain blood supply in cerebral vascular crises development is demonstrated. The latter can proceed as hypertensive ones on the background of emotional overloading and also reflect other features of brain blood supply in its clinical picture e.g. an absence of one of spinal arteries on the background of atherosclerosis and arterial hypertension.

Adolescent↗
PubMed2002

[Secondary stroke prophylaxis: the advantages of care in neurological center for specialized outpatient treatment].

In neurological center for specialized course outpatient treatment, a higher level of medical care, comparing to general clinics, is provided for post- stroke patients. The continuous antiaggregants intake and modern antihypertensive therapy allowed to reduce significantly a frequency of secondary stroke in comparison to standard care for such patients in general outpatient clinics (4.6% versus 24% during a year; p < 0.05). A combined treatment in neurological center promoted a decrease of neurological deficit in 92.6% of all the cases. Positive experience of the secondary stroke prevention unit gives grounds for its introduction in clinical practice.

Ambulatory Care↗
PubMed2001

Sporadic ALS associated with the D90A Cu,Zn superoxide dismutase mutation in Russia.

Twenty blood samples from Russian patients (Moscow) with idiopathic motor neurone disease were analysed for mutations in the Cu,Zn superoxide dismutase (Cu,Zn SOD) gene. Two patients (10%) with the amyotrophic lateral sclerosis (ALS) form of the disease were found to have a disease-related mutation. One patient appears to have autosomal recessive adult-onset ALS associated with homozygosity for D90A and presents the characteristic phenotype of very slowly ascending paresis with both lower and upper motor neurone signs. Another patient, heterozygous for D90A, presents ALS with lumbar onset and rapid progression. This is the first report of a Cu,Zn SOD mutation in ALS in Russia.

Adult↗
PubMed2001

[Change of bioelectric brain activity registered at the distance from the focus of cerebral tissue injury].

The focal delta-waves and the remote influences of the stroke in the form of the sinusoidal flashes of delta-waves with a maximal amplitude exceeding an amplitude of the focal delta-waves (frontal flashes--FF) in frontal-polar leads were investigated in 51 patients (22 men, 29 women) by means of mapping, dipole location (BrainLoc) and LORETA methods. The patients were examined in dynamics during the acute period of hemispheric stroke on days 1-3, 14 and 21 after the onset of the disease. The usage of the modern computer methods of EEG analysis permits to consider FF as an independent electrophysiological phenomenon and to localize a zone of the sources of such flashes, which does not coincide with the zone of generation of the focal delta-activity that corresponds to the perifocal zone of the stroke. According to the data of the three-dimensional location a probable zone of FF generation corresponds to the frontal pole and medial-basal areas of the frontal lobe. Comparison with the MRI data leads to the conclusion that a damage of anterior white substance was the most frequent cause of FF development, probably by deafferentation mechanism. FF may be an electrophysiological manifestation of the influence of the damage of the different brain structures on the frontal lobes according to diaschisis mechanism.

Acute Disease↗
PubMed2001

[Neurophysiological characteristics of transitory global amnesia syndrome].

Twenty seven patients with transitory global amnesia (TGA) in acute and remote (after 7 and more days) stages and 31 dyscircular encephalopathy patients with subjective memory disturbances (control group) have been examined. According to electroencephalographical (EEG) data and wave P300 cognitive evoked potential evaluation, the differences in the beta 1-activity between these groups have been found. beta 1-Activity expression on EEG correlated in different ways with latent P300 periods, increasing together with latent period (r = 0.43) in control group and decreasing in TGA (r = -0.23). The most distinct, changes were expressed in central cerebral regions. The authors hold that the relationship between changes of EEG and cognitive evoked potential in acute and remote TGA stages, as well as in control group, indicate functional character of TGA syndrome, being unrelated to cerebral structure damage.

Aged↗
PubMed2001

[ACE gene polymorphism in patients with ischemic brain disease].

The aim of the present study was to define participation of gene angiotensine converting enzyme (ACE) in the development of atherothrombotic ischemic stroke. 153 patients with cerebrovascular disease were enrolled. The first group consisted of 50 patients with hemispheric atherothrombotic ischemic stroke and their 55 siblings. The second group consisted of 23 patients with chronic cerebrovascular disease with not less than 10 year history but with no history of strokes, including silent ones, and their 25 siblings. All the patients underwent standard clinical and laboratory study, insertion-deletion polymorphism of ACE gene was determined with polymerase chain reaction. chi 2-Test found no statistically significant differences in frequencies of I/D alleles between two groups as well as between genotypes of each group: p < 0.05. During analysis of ACE gene polymorphism in relation to level of arterial hypertension, presence of type II diabetes mellitus as risk factors no statistically significant differences in frequencies of I/I, I/D and D/D genotypes in both groups were found. We studied correlation between insertion-deletion polymorphism of ACE gene and the development of stenosis significantly affecting haemodynamics (over 70%). We found that among patients with stenosis in both groups D/D genotype significantly predominated (p < 0.05).

Adult↗