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Biomedical subjects

V I Levin

Publications and source records attributed to V I Levin.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Characterization of the immune status of patients with vaccine-associated poliomyelitis].

Specific humoral immunity, total immune status and typing of HLA antigens, class 1, in loci A and B were studied in children with vaccine-associated paralytic poliomyelitis (VAPP). The immune status investigation revealed that changes in the content of serum immunoglobulins were most frequent. Out of 8 examined children, 5 children had IgA deficiency and 1 child had total variable immunodeficiency. In one case disturbances in cell-mediated immunity prevailed. Tissue typing revealed the presence of HLA A2 and B44 in 5 out of 6 examined children, which considerably exceeded their average occurrence among the Belorussian population. In spite of frequent detection of immunological disturbances in VAPP patients, out of 38 serologically examined children 36 (95%) were found to have virus-neutralizing serum antibodies to poliovirus, which was indicative of the capacity of their immune system for response to the administration of vaccine virus. To minimize the risk of VAPP in children and to achieve the goal of poliomyelitis eradication the combined immunization scheme consisting of 1-3 vaccinations with inactivated poliovaccine with subsequent administration of oral vaccine prepared from attenuated Sabin viruses is regarded as most promising.

Alleles↗
PubMedDate not supplied

[Generation of active forms of oxygen by human peripheral blood neutrophils and lymphocytes during adhesion to glass].

Oxygen activation by neutrophils and human blood lymphocytes at adhesion to glass have been studied by luminol--dependent chemiluminescence. It has been established that the cell interaction with glass leads to the formation of O2-., O2', .OH and H2O2. Chemiluminescence kinetics and the excited--oxygen forms ratio at adhesion were different for neutrophils and lymphocytes. The desorption of cells resulted in a decrease of the chemiluminescent response to neutrophils and lymphocytes when they again adhered to glass and in practically complete inhibition of chemiluminescence induced by adding concanavalin A. It has been determined that at adhesion of neutrophils and lymphocytes to glass different mechanisms of oxygen activation take place.

Cell Adhesion↗
PubMedDate not supplied

[Structural properties of leukemic and normal lymphoid cells].

DNA synthesis intensity and spectral and fluorescent properties of leucemic, PHA-induced and intact normal mouse spleen cells and of nuclei isolated from these cells were investigated. The cell electrophoretic mobility and DNA-protein interaction in the nuclei were studied. Similarity in cell and nuclei fluorescence, fluorescence of the probe ANS conjugated with the cells, the electrophoretic mobility and tightness of DNA--protein interaction for leucemic and PHA--induced cells and also the similarity of the tightness of DNA--protein interaction for leucemic and normal intact cells were found inspite of the differences in DNA synthesis intensity and cell functional peculiarities.

Animals↗