[Possibilities of using anti-HLA sera in modulating the functional properties of lymphocytes and passive immunotherapy].
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Biomedical subjects
Publications and source records attributed to V I Levin.
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HLA-antigen distribution in 93 patients with amyotrophic lateral sclerosis did not differ from that in the control group. Yet, there were significant differences in antigen levels both between different variants of the disease and as compared to the control values.
Examinations of the HLA antigens (A and B loci) distribution in patients with neurologic manifestations of lumbar osteochondrosis (NMLO) has revealed a statistically more rare incidence of A11 antigens and a more frequent one, of B7 and B18 ones. A different distribution of the antigens in cases with the major clinical forms of lumbar osteochondrosis was noted. Patients with discogenic lumbosacral radiculitis differed from normal subjects by the same antigens as all NMLO patients. For patients with lumbar ischialgia increased concentrations of B7 and B18 antigens were characteristic, whereas in radicular ischialgias A11 and B15 antigens were less incident and B40 one, more incident. The findings confirm the polygenic nature of hereditary predisposition to NMLO.
Distribution of HLA antigens of A and B loci was studied in 200 schizophrenics, 77 patients with manic-depressive psychosis of different forms, and in 350 healthy individuals. The findings included a significant elevation in the levels of the B7 antigen in both groups of patients, of antigen B12 in individuals with paroxysmal schizophrenia as well as a decrease in the concentrations of antigen B35 in recurrent schizophrenia. Patients with monopolar manic-depressive psychosis showed increased content of antigen B14 and decreased levels of antigen B5. The data obtained confirm heterogeneity of endogenic psychoses with regard to this sign.
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A study was made of the rate of HLA system antigens in 75 patients with different clinical versions and immuno-pathological manifestations of systemic lupus erythematosus (SLE). A total of 350 normal subjects comprised the control group. During SLE, a high rate of DNW3, B8 and AI antigens was revealed. Associative relations were established between individual clinical syndromes of SLE and immuno-pathological manifestations of the disease and definite antigens of the HLA system. The results of typing HLA system antigens can be used as additional criteria of SLE diagnosis, disease prediction, and choice of adequate therapy schemes.
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Preparations of RNA and histones change the electrophoretic mobility of lymphoid cells, the intensity of their respiration and anaerobic glycolysis, and thermo-merchanical properties of DNA-complexes isolated from lymphoid cells. RNA and histones exert their influence on the properties of DNP-systems and the rate of anaerobic glycolysis in the opposite manner. But both these preparations depress the electrophoretic mobility and oxygen consumption.