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Biomedical subjects

V I Kozlov

Publications and source records attributed to V I Kozlov.

At least 37 records · Page 2Linked to original sources

[Erythrocyte concentration in vessels of the microcirculatory bed of the mesentery of the white rat (according to the results of in vivo microcinematography)].

The red cells velocity and hematocrit value were studied with high-speed microfilming in microvessels of albino rat mesentery. Decrease of the red cells velocity and increase in the number of microvascular branching were followed by a decrease in the hematocrit value: 20% in the precapillary arterioles and 16% in capillaries. The concentration of erythrocytes increased to 26% in venules. The magistral communication between arterioles and venules has a specific place among microvessels. These channels are relatively wider, the red cells velocity is high (0.9 mm/sec) as well as the hematocrit value (23%). Variation of hematocrit value in capillaries is not solely the function of their volume but also the function of their position in capillary net.

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[Structural changes and hemodynamic relations in the microcirculatory bed of the mesentery of the white rat during the period of sexual maturation].

Structural changes and hemodynamic relations have been studied in the microcirculatory bed of the white rat small intestine mesentery during sex maturation (from the 3d up to the 10th week of the postnatal development). All calculations are performed regarding the mesenteric segment limited with two intestinal arteries, which is considered as an elementary microvascular module. Complication of the microcirculatory bed construction takes place at the expense of increasing number (nearly five-fold) of microvessels in the segment and increase of the capillary network density. The hemodynamic factor plays a certain role for stimulating the process of the capillary growth. The definitive structure of the mesenteric microcirculatory bed is completed by the 7th week. The main rearrangement of the microcirculatory system during the developmental process from a simple arterio-venular loop up to a complex microcirculatory bed with a branching capillary network is performed within the limits of the mesenteric segment.

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Demography↗

[Structuro-functional organization of the microcirculatory bed of the skeletal muscles].

Structure of the microcirculatory bed in the white rat musculus spinotrapezius and m. quadriceps femoris has been studied by means of biomicroscopic methods, as well as by means of injection and non-injection methods for revealing microvessels. Spatial arrangement of the microvessels has been followed and certain zonal functional complexes of microvessels in the muscle--myoangions--have been revealed. Polymeric-homonomous form of the microcirculatory bed organization in the muscle is substantiated. Capillary bed capacity is calculated and its reserve possibilities are estimated in the resting muscle. It has been demonstrated that geometry on distribution of functioning capillaries in the muscle is arranged in such a way that to ensure the most optimal conditions for metabolism in the muscle tissue, while keeping maximal reliability of the transorganic circulation pathways.

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[Change in the permeability of vessels in the microcirculatory bed of skeletal muscles in conditions of working hyperemia].

Permeability of m. quadriceps femoris and m. gastrocnemius mimicrocirculatory bed of albino rats was studied by fluorescent biomicroscopy at rest and under work hyperemia. Fluorescein-labeled bovine globulin (FBG) was used as an indicator of permeability alteration. Quantitative fluorescent analysis was carried out on a microspectrofluorimeter. In work hypermia the FBG concentration in the muscle exceeded such at rest by 40--45%; this evidenced an increased transendothelial transport. The results of the experiments on the measurement of FBG concentration about a single capillary suggested that the microcirculatory bed permeability increased under work hyperemia.

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[Reaction of vessels of the microcirculatory bed of subcutaneous tissue to exposure to an argon laser beam].

The effect of argon laser irradiation on the microvessels of the subcutaneous fat tissue of rabbit's ear placed into Clark's transparent chamber was studied. Capillaries and venules were found to be sensitive to argon laser irradiation; functional disturbances of microcirculation were most distinct. Following laser irradiation an active reconstruction of the microcirculatory bed with the redistribution of the blood stream took place along with destruction of the vascular wall and perivascular inflammation.

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[Morphofunctional characteristics of the microcirculatory bed of the cochlear portion of the otic labyrinth].

It has been shown that the microcirculatory system of the cohlear portion of the labyrinth is a complex of vessels adapted to the organ function. The analysis of the blood passages in the cochlear channel has shown that in accordance with the organ structure there occurs a spacious subdivision of the micrcirculatory bed into working units (segments) which are functionally integrated into a single microcirculatory system. Quantitative estimation of the microcirculatory system parameters has shown that 1) the blood volume which comes into the microcirculatory system is distributed between the vessels as following: 26%--arterioles: 8%--precapillaries; 29%--capillaries; 8%--postcapillaries and 29%--venules. 2) 639 capillaries fall on 1 mm-2 of the vascular strip and their diffuse surface is 1,3 mm-2.

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[Analysis of the structural parameters of the blood flow pathways in the microcirculatory system].

The reconstruction of the mesenterium microcirculatory bed was performed intravitally in albino rats and cats after biomicrophotograms. The number, length and caliber of arterioles, pericapillary arteriolec, capillaries, postcapillary venules and venules of the mesenterium were measured. According to these data summary indices of the cross section, surface and volume of the vessels of various functional subdivisions of the microcirculatory bed were calculated. The blood volume entering the microcirculatory system of the albino rat's mesenterium is distributed in the vessels as follows: 8,4% -- arterioles, 10,2% -- pericapillary arterioles, 41,9% -- capillaries, 22,1% -- postcapillary venules and 17,4% -- venules. Similar correlations were found in the cat. The working surface of capillaries is 60--70% of the working surface of all the vessels of the mesenterial microcirculatory system. The evidence of the functional variability of the microcirculatory bed geometry depending on the tissue needs in blood supply is presented.

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[Study of the microcirculation of the wall of the stomach of white rats by the vital microscopy method].

Microcirculation of the gastric wall in the albino rat was studied by the method of vital microscopy in passing light. The conditions of the experiment permitted watching the microcirculation state during 5-6 hours. Intravital morphometry of the microcirculation bed vessels was made. The obtained data concerning the intravital angioarchitectonics of the gastric wall vascular bed were in good agreement with a conventional scheme of its blood supply. The role of arteriolevenular anastomoses in redistribution of blood within the bloodflow pathways was noted.

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