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Biomedical subjects

V I Kandror

Publications and source records attributed to V I Kandror.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[TRH test after subtotal thyroid resection for diffuse toxic goiter].

Altogether 25 patients were examined one month after subtotal resection of the thyroid for diffuse toxic goiter. A wide spectrum of the TSH to TRH reaction was detected. The nature of this reaction made it possible to single out 4 groups of patients with a progressively decreasing and even paradoxical response of TSH to TRH. There were no correlations between the nature of the TSH to TRH reaction and the patients' thyroid status in the pre- and postoperative period, time-period of disease and the expression of autoimmune processes. Profound changes in function of the pituitary-hypothalamo-thyroid system were found in most of the patients at the above mentioned time after operation.

Antibodies↗
PubMedDate not supplied

[State of the insular apparatus in experimental thyrotoxicosis].

The oral intravenous glucose tolerance tests revealed an increase in the rate of glucose utilization in rabbits fed high thyroidine doses. Hypoglycemia and hypoinsulinemia on fasting stomach, as well as a reduction of insulin reaction to intravenous glucose load were seen in such animals. A fall of insulin secretion in thyrotoxicosis is considered to be a compensatory reaction permitting glucose output from the liver to meet increased tissue demands in the oxidative substrates.

Animals↗
PubMedDate not supplied

[Determination of autoantibodies to pancreatic beta-cells, non-islet endocrine cells and fibroblasts in patients with newly detected diabetes mellitus].

The clinical onset of insulin-dependent diabetes (IDD) is characterized by the onset of circulation of autoantibodies to beta-cells. Thirty-three newly detected IDD patients and 14 newly detected patients with noninsulin-dependent diabetes mellitus were examined for autoantibodies to antigen P 64-69, to surface antigen of islet cells, to thyrocyte microsomal fraction, thyroglobulin, hypophysis, fibroblasts; the levels of circulating immune complexes were measured as well. IDD debut was found associated with the appearance of antibodies to pancreatic islet cells, thyroid, thyroglobulin, hypophysis, fibroblasts, this indicating a polyclonal activation of the immunity system. A relationship was revealed between antifibroblast antibody and anti-islet-cell antibody. Antihypophyseal antibodies were detected in 43% of patients with noninsulin dependent diabetes. Nine per cent of IDD patients and 24% of patients with noninsulin dependent condition were negative in the tests.

Adolescent↗