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Biomedical subjects

V I Kandror

Publications and source records attributed to V I Kandror.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Citrate content in the myocardium and liver of rabbits in starvation and thyrotoxicosis].

Under starvation in rabbit blood plasma an increase in content of free fatty acids was accompanied by accumulation of citrate in myocardium and by maintenance of glycogen content in the organ. Contents of glycogen and citrate were decreased in liver tissue. In blood plasma under thyreotoxicosis an increase in concentration of free fatty acids was followed by decrease in contents of glycogen and citrate both in myocardium and in liver tissue. Under thyreotoxicosis the absence of the glycogenolysis block was associated with non-accumulation of citrate in myocardium. Difference in metabolic patterns of fatty acids in heart and liver tissues under starvation and thyreotoxycosis are discussed.

Animals↗
PubMedDate not supplied

[Experimental thyrotoxicosis under conditions preventin hyperlipacidemia].

Prolonged administration to rabbits of nicotinic acid was accompanied by a fall in glucogen level in the liver and hyperglycemia. Consumption of O2 by the animals, their weight, and also the volume circulation along the main vessels and the pulse frequency remained unchanged. Thyroidin administration to rabbits led to increase in the content of free fatty acids (FFA) in the plasma, reduction in the glycogen level in the liver and the myocardium a sharp fall in body weight of the animals, an increase of O2 consumption by them, tachycardia and an increase in the volume circulation. A simultaneous administration of thyroidin and nicotinic acid blocked an increase in the FFA level in the plasma and led to a greater fall in the glycogen content in the liver, but failed to alter any other manifestations of thyrotoxicosis. The authors concluded that the thyrotoxic hypermetabolism was independent of increase in the blood FFA level and their tissue oxidation. Various mechanisms of the calorigenic effects of catecholamines and of the thyroid hormones are analyzed; it is supposed that hypermetabolism of any genesis had an increase of free thyroid hormones in the blood as the common final link of its development.

Animals↗
PubMedDate not supplied

[Determination of autoantibodies to thyrotropin receptors in patients with diffuse toxic goiter].

The blood level of antithyroid autoantibodies to TSH receptors was determined in patients with toxic goiter (TG) before and during antithyroid therapy using two biological methods (by the increment in the cAMP level in slices and primary monolayer culture of human thyroid cells) and a radioreceptor method (by inhibition of TSH binding with its receptors from the animal thyroid). Comparison of the results of these three methods has shown that all methods are almost equally valuable for diagnosis of new cases of TG. However the biological method was shown to be more sensitive and informative with regard to predicting the time of immunological remission during antithyroid therapy.

Adolescent↗
PubMedDate not supplied

[Dynamics of thyrostimulating immunoglobulin levels during treatment of diffuse toxic goiter].

Twenty-five patients with diffuse toxic goiter, investigated at various time of mercazolyl therapy, demonstrated the presence of thyrostimulating immunoglobulins in 100% before treatment, in 91% after 6 months and in 50% after 12 months of treatment. Specific therapy reduced considerably not only the frequency of detection but also the activity of thyrostimulating immunoglobulins. Clinical and hormonal remission of disease did not always coincide with immunological remission.

Adolescent↗
PubMedDate not supplied

[The relationship of endocrine ophthalmopathy to the thyroid status and to the indices of an autoimmune lesion of the thyroid].

The paper is devoted to a study of the pathogenetic relationship of endocrine ophthalmopathy with thyroid diseases. Altogether 76 patients with endocrine ophthalmopathy combined with various thyroid lesions (diffuse toxic goiter, Hashimoto's disease, primary hypothyrosis) and without thyroid diseases were investigated. The serum level of thyroid hormones, the content of Ig A, M, G, thyroglobulin and the presence of antithyroid antibodies were analyzed. HLA typing by A, B, C, D2 loci was done for a group of patients. The results did not show correlation of the origin and gravity of ophthalmopathy either with thyroid function or with the factors determining thyroid affection. Some differences in the genetic markers of endocrine ophthalmopathy and autoimmune thyroid diseases were also established.

Adult↗
PubMedDate not supplied

[Characteristics of the endocrine function of the pancreas in diffuse toxic goiter in children].

The examination of 28 children with diffuse toxic goiter showed disturbance of glucose tolerance with a significant decrease in the level of C-peptide in the blood serum and its response to glucose. The concentration of immunoreactive insulin (IRI) and its increment under the influence of a glucose tolerance test in children was much above the normal. At the same time the molar C-peptide/IRI ratio in the patients' sera both on an empty stomach and during the glucose tolerance test showed a dramatic decrease indicating the reduction of insulin extraction by the liver as a cause of peripheral hyperinsulinemia. Distortion of the plasma immunoreactive glucagon reaction to a glucose tolerance test was observed in children with diffuse toxic goiter.

Adolescent↗
PubMedDate not supplied

[Reflexometry: an early prognostic test for assessing postoperative hypothyroidism].

The serum content of thyroxin (T4) and the duration of Achilles reflex was studied in 23 patients with toxic goiter 1-3 months after subtotal thyroidectomy. Concentration of T4 assessed in the serum revealed 9 euthyroid subjects and 14 patients with hypothyrosis. But as the duration of Achilles tendon reflex was within the norm in all 14 hypothyrosis patients reflexometry technique turned to be inconsistent in distinguishing between hypo- and euthyroidism. However the high prognostic value of this method for differential diagnosis of transient or long-standing forms of the disease was shown. Six months after the surgery hypothyrosis disappeared spontaneously, i.e. turned to be transient, in 5 patients whose Achilles tendon reflex parameters were normal, though in all 9 hypothyrosis patients with the reflex parameters higher than 350 m/s clinical and biochemical signs of thyroid under-activity were detected. The data obtained give evidence in favour of reflexometry to be used for early prognostic assessment of post-operative hypothyrosis.

Achilles Tendon↗
PubMedDate not supplied

[Mechanisms of hormonal regulation of blood glucose in thyrotoxicosis].

Rabbits with thyrotoxicosis develop at the early stages of this pathology hyperglycemia, and, as the disease persisted and grew more severe, hypoglycemia. The insulin level in the peripheral blood decreases progressively in the time course of thyrotoxicosis; insulin response to glucose, a specific stimulus, also weakens. The idea of glucose utilization by muscles regardless of the insulin effect is postulated basing on analysis of the authors' and literature data. Its main physiological function in the body is supposed to be the inhibition of glucose production by the liver and free fatty acids by the adipose tissue.

Animals↗