Biomedical subjects
Publications and source records attributed to V I Borisov.
The paper reveals shortcomings of medical care for cancer outpatients. Basing on cancer incidence and analysis of the activities of outpatient oncological units, measures are brought forward to advance prophylactic, diagnostic and therapeutic service for cancer outpatients.
Results of treatment of 433 patients with stage IIIb breast cancer were analysed. Large-fraction radiation treatment and combination chemotherapy followed by surgery proved superior to standard fraction irradiation plus surgery for the initial treatment of stage IIIb breast cancer.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Cooperative clinical trials of a newly-developed antibiotic--bleomycetin (a purified fraction of bleomycin A5) conducted in 172 patients at 7 oncological centers revealed a spectrum of antitumor activities similar to that displayed by Japanese-made bleomycin. When administered by intravenous or intramuscular injection in single or total doses amounting to only 50-70% of those of bleomycin (bleocin), bleomycetin proved effective in the treatment of extended squamous cell carcinoma of the head and neck, skin, cervix uteri, embryonal cancer of the testicle and, particularly, recurrent Hodgkin's disease and non-Hodgkin's lymphoma. Single administration of 15-50 mg bleomycetin (total dose--50-150 mg) to serous cavities was followed by the cure of specific pleurisy and ascites in 47%. Unlike bleomycin, bleomycetin treatment was free of pulmonary toxicity, and skin hyperpigmentation, hyperkeratosis, vomiting and alopecia were significantly less frequent.
Explore the source record for details and available documents.
Indications for and organization of outpatient radiation and chemotherapy of cancer are discussed. Schemes of treatment for cancer of major sites are described. Possible contraindications for this were identified. Fund saving is another advantage of outpatient therapy.
Explore the source record for details and available documents.
For the purpose of improving the effectiveness of the chemotherapy of gastrointestinal tract tumours, the experimental investigation of the possibility to deposit the various antitumour preparations in the abdominal cavity by including them into acetylcellulose microspheres was carried out. It was shown that the use of the polymeric drug complexes permits obtaining a significantly more pronounced antitumour effect than the introduction of the same preparation in a free form. A decrease of the toxic effect of the deposited preparations was established.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.