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Biomedical subjects

V I Borisov

Publications and source records attributed to V I Borisov.

At least 19 recordsLinked to original sources
PubMed1992

[The current status of the problem and the treatment possibilities in disseminated malignant neoplasms of the maxilla].

A study of the results of treatment of 170 patients makes a case for combined electrosurgical resection of the maxilla and local chemotherapy with deposited cytostatic drugs for localized malignant tumors of this site. No recurrences were detected within the first 12 months in 75.4% of patients and 52%--in control. Three-year survival in treated patients and controls was 67 and 48%, respectively.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1991

[Polymer-drug complexes in the treatment of extensive ovarian cancer].

The paper presents the results of intracavitary chemotherapy with deposited cytostatics of advanced ovarian cancer as well experimental, morphological, biochemical and pharmacological data. Intraabdominal introduction of microspheres filled with cyclophosphamide, 5-fluorouracil, doxorubicin can be a variant of drug therapy in multimodality treatment of ovarian cancer. Combination of intracavitary chemotherapy with a systemic one has the advantage of local and regional effect which is not inhibited by mediated action of the deposited cytostatics via the systemic blood flow. The method is indicated in residual tumor dissemination after cytoreductive surgery and ovarian cancer with ascites.

Adult↗
PubMed1991

[Repair of ventricular septal defects with pericardial xenografts in infants].

The article deals with the experience in the clinical use of pericardial xenografts in surgical correction of large ventricular septal defects in babies. Primary closure of the VSD under conditions of hypothermic perfusion at a low volume rate was carried out in 202 children whose ages ranged from 6 weeks to 12 months and body weight from 3.5 to 10 kg. The aorta was not clamped. In 142 patients the defect was closed with xenogenous pericardium treated with 0.6% glutaraldehyde solution on HEPE buffer and 1% sodium dodecyl sulfate solution. A pericardial xenograft treated by Carpantje's method was used before 1985 (59 patients). The hospital mortality rate was 6.4% (13 patients). The mortality rate was 5.1% among patients over 6 months of age and 11% among those under 6 months of age, which is explained by their initially extremely grave condition. The long-term results were studied in 133 patients by bidimensional and Doppler echocardiography. The pressure in the right ventricle was found to be normal (26 +/- 4.3 mm Hg) in all patients. The right- and left-ventricular end-diastolic volumes were normal, just like the ejection fractions (55.4 +/- 6.6 and 57.3 +/- 6.8%, respectively). A small escape of blood at the level of the graft was found in only 5% of patients. Mild incompetence of the tricuspid valve without clinical manifestations was revealed in 18% of patients. In none of the cases, signs of calcinosis or aneurysm of the graft were found, fatal outcomes in the long-term postoperative periods were not encountered.(ABSTRACT TRUNCATED AT 250 WORDS)

Bioprosthesis↗
PubMed1991

[Effect of potassium iodide on tumor growth].

In the experiments on mice with primary tumors the authors studied the effect of iodine potassium on tumoral growth. It was shown that tumors became smaller in those animals who obtained iodine potassium. Possible mechanisms of this effect are being discussed.

Administration, Oral↗
PubMed1990

[Chemotherapeutic pathomorphosis of breast cancer].

Features of pathomorphism of mammary carcinoma were studied in 177 women after a course of drug therapy. Qualitative and quantitative morphologic changes in the tumor were poorly manifest: they were detected in only 54 percent of patients and only in 9 percent the effect was manifest (third-fourth stage of involvement). Characteristic findings here were augmentation of cellular dystrophy, necrotic changes, enhanced nuclear polymorphism; significant injury to tumor parenchyma was paralleled by development of xanthomatosis foci and lymphoid histiocytic infiltration.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[Radical correction of tetralogy of Fallot in infants under 1 year of age].

The article generalizes the experience in surgical treatment of Fallot's tetrad in 20 infants. Radical correction of the anomaly was carried out under extracorporeal circulation and deep hypothermia with reduced volume rate of perfusion. Plastics of the conus arteriosus alone was performed in 6 patients, transanulus and the pulmonary trunk in 4 patients. Two patients died, the hospital lethality was 10%. A clinical effect was produced in all the other patients. The relation of systolic pressure in the left ventricle to that in the right ventricle was 0.56 +/- 0.1, the systolic pressure gradient between the right ventricle and the pulmonary artery was 18 +/- 4.2 mm Hg. Various degree of regurgitation at the pulmonary valve was revealed after the operation in all patients. It was maximum (34 +/- 10%) in transanulus plastics.

Age Factors↗
PubMed1990

[Approaches to predicting the reaction of human tumors to radiotherapy].

Immunofluorescent method using anti-thymidine antibodies was employed to assess proliferative activity of 217 human tumors including oropharyngeal, esophageal, gastric, rectal and lung cancer. The activity was evaluated before and, in 38 neoplasms, in the course of radiotherapy. It was shown that changes in the proliferative activity of oropharyngeal and gastric malignancies observed early in the course of radiation treatment may serve for predicting response.

Esophageal Neoplasms↗