Biomedical subjects
Publications and source records attributed to V Hempel.
In Vitro experiments with rat liver microsomes (difference spectra, p-nitroanisol-demethylation) and in vivo experiments with rats (tritium release from 3H-mestranol) suggest an inhibition of the metabolism of certain drugs (type-1-substrates) by competition for the binding site of cytochrome P-450 under anaesthesia with diethyl ether, halothane, enflurane and methoxyflurane.
In a group of 12 hypovolemic patients some parameters of circulation and kidney function were measured before and after an infusion of 1000 ml 6% hydroxyethyl starch solution (HES) was given. There were found increases in cardiac output, centralvenous pressure and endogenous creatinine clearance, and decreases of total peripheral resistance and shock index. Under the conditions of this investigation HES solution showed good properties as a plasma substitute.
In 14 patients undergoing surgery with methoxyflurane anaesthesia the development of metabolic acidosis was observed. As mechanisms causing such acidosis regional ischaemia and inhibition of lactic acid metabolism in the liver by breakdown products of methoxyflurane are discussed.
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