[A method of suturing the laparotomy wound in postoperative eventration].
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Biomedical subjects
Publications and source records attributed to V G Morozov.
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Under observation there were 186 patients with thermal burns and 59 patients with frostbites of hands and fingers. Free skin plasty with a splitted autotransplant was used in 29 patients. Plasty on a temporary feeding pedicle was used in 39 patients. Better results were obtained in remote terms in patients after non-free dermoplasty. In patients with burns and frostbites of the IVth degree no labour rehabilitation was achieved.
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The study was concerned with the influence of postnatal treatment with antioxidant tocopherol, antidiabetic drug phenformin and low-molecular polypeptide factors of the thymus (thymalin) and pineal gland (epithalamin) on transplacental carcinogenicity of low-dose (7.5 mg/kg body weight, 3.2% of LD 50) N-ethyl-N-nitrosourea (ENU) in rats. Transplacental exposure to ENU was followed mainly by the development of brain tumors. Tumors of the spinal cord, peripheral nervous system and kidney were observed much more rarely. Treatment with tocopherol, thymalin or epithalamin did not significantly influence the transplacental carcinogenicity of ENU, whereas application of phenformin was followed by a decreased incidence of brain tumors.
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The polypeptide preparations cortexin and encephalin from grey and white substances of the cattle brain injected in the postnatal period are studied for their effect on the development of the nervous system and kidney tumours in rats induced transplacentally by N-nitroso-N-ethylurea. The two preparations decreased both the incidence and multiplicity of the brain tumours. It is supposed that the anticarcinogenic effect of these preparations is due to their normalizing action on the differentiation and proliferation of the brain glia cells.
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Polypeptides excreted from the heart have been shown to exert a positive influence on myocardial infarction caused by izadrin injection in experimental rats.
Polypeptide factor isolated from vascular wall of the cattle ("vasonin") was shown to affect the immunogenesis and hemostasis, to stimulate kallikrein-kinin system and to accelerate processes of regeneration.
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A rapid indirect enzyme immunoassay technique for the determination of thymalin, a polypeptide thymus factor, with sensitivity equal to 1.5 X 10(-8) mol/l has been developed. The accuracy of determinations, measured by the variation factor, has proved to be 5-10% in the interassay, 10-15% in the interassay, the reliability in the opening test being 5%. The assay takes 4.5-5 hours.
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The effect of polypeptides from the thymus, bone marrow and bursa of Fabricius on immunogenesis and hemostasis was investigated in neonatally thymectomized and antenatally bursectomized chickens. It has been established that polypeptide factors from the bursa of Fabricius have the most pronounced effect on the immunity and hemostasis.
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