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Biomedical subjects

V G Kukes

Publications and source records attributed to V G Kukes.

137 records · Page 8Linked to original sources
PubMedDate not supplied

[Pharmacokinetic characteristics of lidocaine in patients with circulatory failure].

It has been shown with special reference to 35 patients suffering from myocardial infarction, atherosclerotic cardiosclerosis and rheumatic heart diseases associated with varying degrees of circulatory insufficiency that the final amount of distribution and halflife of lidocaine directly correlated with the cardiac index. A formula has been suggested for calculating the amount of distribution of the drug on the basis of the cardiac index. It has been demonstrated that the formula can be used for the development of therapeutically effective lidocaine concentration in the patients' blood.

Coronary Disease↗
PubMedDate not supplied

[A pharmacokinetic study of korinfar-retard in monotherapy and in combination with cordanum and triampur in patients with arterial hypertension].

The long-acting corinfar formulation, corinfar-retard tablets, 20 mg (AWD, Germany), was studied for pharmacokinetics in single and course use in 40 patients with arterial hypertension, as well as for its effects of cordanum and triampur. Patients' plasma corinfar was measured by high performance liquid chromatography. There were no changes in the pharmacokinetics of the agent when it was used in its course use. Cordanum and triampur was demonstrated to have no effects on the pharmacokinetics of corinfar during their application.

Adolescent↗
PubMedDate not supplied

[The pharmacodynamic and hypotensive efficacy of proxodolol in an acute drug test on hypertension patients].

The antihypertensive efficacy and hemodynamic effects of the new hybrid (beta-, alpha-) adrenoceptor blocking agent proxodolol were studied in 74 patients with mild, moderate, and severe arterial hypertension who received a single dose of 10, 20, or 40 mg. Oral and intravenous proxodolol showed a significant dose-dependent antihypertensive action which was independent of the type of hemodynamics and manifested itself by decreasing cardiac output.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

[Theopek absorption efficiency in chronic diseases of the large intestine].

A total of 10 patients with chronic ulcerative colitis (CUC) were examined. The patients took a single dose of theopec (300 mg). The patients with chronic obstructive lung diseases (COLD) without intestinal disorders served as controls. Blood theophylline concentrations were measured by high performance liquid chromatography. The absorptive efficiency of theopec was comparatively evaluated in patients with CUC and those with COLD without intestinal disorders. The use of the drug in patients with CUC resulted in the unneeded high serum theophylline concentrations.

Adult↗
PubMedDate not supplied

[The pharmacokinetic and pharmacodynamic characteristics of foridon during interaction with the metabolic oxidation inhibitor dopegit].

The paper deals with some aspects of the effects produced by dopegite on the pharmacokinetics and pharmacodynamics of foridone from a group of calcium antagonists. Nineteen patients with essential hypertension received a single doses of foridone of 40 mg, then its course therapy in a dose of 90 mg/day for 2 weeks, then it was supplemented with dopegite in a dose of 750 mg/day for 2 weeks too. Supplementation of dopegite caused statistically significant changes as higher plasma concentrations of foridone and increased concentration-time curve areas, decreased total peripheral resistance and regional, and a lower spasm index. Dopegite can be used to enhance the antihypertensive effect of foridone.

Adult↗
PubMedDate not supplied

[The pharmacokinetics of different drug forms of nifedipine when used singly and in a course as monotherapy and in combination with Cordanum and triampur preparations in patients with arterial hypertension].

Pharmacokinetics of three drugs derived from nifedipine: corinfar, corinfar retard, and SL adalate in the cases of a single and course administration in patients with arterial hypertension and the effect of cordanum and triampur on pharmacokinetics of corinfar retard in combined repeated administration have been studied. The studies were carried out in 6 groups of patients with arterial Hypertension, each group included 10 patients. Nifedipine concentration in blood plasma was determined using a special HPLC procedure within 24 h after administration of the drugs at a dose 20 mg. A pharmacokinetic characteristics of new drug adalate SL with two-step liberation of nifedipine. A possibility of autoinhibition was noted for corinfar and adalate SL in course therapy. A conclusion was made that cordanum and triampur did not affect the pharmacokinetics of corinfar retard.

Antihypertensive Agents↗