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Biomedical subjects

V G Kukes

Publications and source records attributed to V G Kukes.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

[Use of traditional methods in medicine for treating moderately severe bronchial asthma].

Minor therapeutic "cups" bloodletting, a variety of little known in Russia but conventional in China method, was compared in efficiency to chemotherapy, acupuncture and phytotherapy in allergic and non-allergic forms of bronchial asthma. The bloodletting alone or in combination with acupuncture and phytotherapy stabilizes the course of asthma and prevents asthmatic attacks, reduces routine doses of necessary broncholytics and glucocorticosteroids.

Acupuncture↗
PubMedDate not supplied

[Clinical significance of the pharmacokinetic interactions between drugs and phytopreparations].

In modern clinics, the pharmacotherapy is frequently accompanied by the administration of phytopreparations (by which are implied any preparations based on or containing plant materials). There are many data indicative of the possible pharmacokinetic interactions between drugs and phytopreparations. Among the most important issues is the ability of components of phytopreparations to induce or inhibit the isoenzymes of cytochrome P-450 and/or glycoprotein P. For this reason, phytopreparations can either increase or decrease the efficacy of jointly admninistared drugs, as well as provoke the development of undesired side reactions.

Cytochrome P-450 Enzyme System↗
PubMedDate not supplied

[Acebutolol and diacetolol: their binding to plasma proteins and erythrocytes and secretion with the saliva].

Thirty-two patients with hypertensive disease were treated with a cardioselective blocker of beta-adrenergic receptors acebutolol ("Sectral-400", Rhone Poulenc, France). The binding of the drug and its metabolites diacetolol to plasma proteins and erythrocytes and their excretion with the saliva were studied. The significant binding of acebutolol and diacetolol to erythrocytes was shown. The ratio of the content of the free form of these substances in erythrocytes to plasma content was on the average 1.54 +/- 0.96 for diacetolol and 1.93 +/- 1.01 for acebutolol. A good correlation of acebutolol and diacetolol contents in the saliva with their contents in plasma was found. The mean values of the protein-bound fraction were for acebutolol 0.133 +/- 0.038 and for diacetolol 0.106 +/- 0.050.

Acebutolol↗
PubMedDate not supplied

[The effect of fenigidin (nifedipine) and verapamil on renin activity, the levels of ionized calcium and aldosterone in the blood plasma and on the hemodynamic indices of rats with spontaneous hypertension].

Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. It was established that nifedipine by its effect on the parameters of hemodynamics and the condition of renin-angiotensin system as well as the blood plasma ionized calcium level is superior to verapamil.

Aldosterone↗
PubMedDate not supplied

[Clinical pharmacology of beta-adrenoblockaders].

The latest data on pharmacokinetics, pharmacodynamics and side effects of beta-adrenoblockers are presented. Based on the data, the indications and contraindications for the use of beta-adrenoblockers in clinical practice are determined.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Pharmacokinetic characteristics of propranolol in patients with a history of acute myocardial infarct].

Peculiarities of propranolol pharmacokinetics in patients with acute myocardial infarction were determined after oral administration of 80 mg of the drug and compared with control group of patients with stage II hypertensive disease: a significant increase of Cmax, Tmax and AUC without changes of kel and T1/2. A direct linear correlation (r = 0.86, p = 0.02) and inverse linear correlation (r = -0.54, p = 0.1) with the duration of the disease were revealed.

Adult↗
PubMedDate not supplied

[Cimetidine pharmacokinetics].

The pharmacokinetics of cimetidine was studied in 9 patients at a single intravenous (200 mg) and oral (400 mg) administration. The pharmacokinetic parameters at intravenous administration were calculated according to a two-compartment model. The time-concentration curve after oral drug administration had two maxima between 45 min and 2 hrs with approximately equal concentrations of cimetidine. The main pharmacokinetic parameters of cimetidine were calculated as follows: t1/2 beta = 1.7 h, t1/2 alpha = 0.12 h, Vd = 1.0 1/kg, Cis = 0.43 1/kg/h, Cior = 1.2 1/kg/h, bioavailability 36%. At the course treatment (1 g per day) cimetidine concentration before the morning dose on the 6th and 12th days remains at the same level.

Administration, Oral↗
PubMedDate not supplied

[Pharmacokinetics of the new Soviet anti-arrhythmia preparation etacizin].

Ten patients without marked abnormalities on the part of the liver and kidneys were examined for the pharmacokinetics of a new Soviet antiarrhythmic drug etacizin. The drug was injected intravenously at a rate of 0.5-0.8 mg/kg bw. The blood required for determining drug concentrations was taken 1, 2, 3 and 4 hours after drug jet injection. It was demonstrated that the drug half-life was on the average 164 +/- 24.7 min, exceeding 2 times the half-life of etmozine, a drug of the same series applied to the treatment of some forms of heart rhythm abnormalities.

Anti-Arrhythmia Agents↗
PubMedDate not supplied

[Pharmacokinetic characteristics of zixoryn used in single and multiple doses].

Nine patients with normal live and renal functions were examined for the pharmacokinetics of zixorine after a single oral administration in a dose of 300 mg. In 7 of these patients given multiple doses of zixorine, its pharmacokinetics was reinvestigated. Six of the 7 patients manifested deceleration of drug biotransformation instead of expected self-induction of biotransformation. The reasons for such a phenomenon are discussed. Four patients were examined for the time course of zixorine biotransformation.

Benzhydryl Compounds↗