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Biomedical subjects

V Brodan

Publications and source records attributed to V Brodan.

At least 91 records · Page 5Linked to original sources
PubMed1976

Changes of free amino acids in plasma of healthy subjects induced by physical exercise.

In eight healthy men a 20-min load of 1.5 W/kg body weight on a bicycle ergometer led to a significant increase of alanine and decline of leucine. Exhausting exercise caused in the same subjects a highly significant increase of alanine and decline of isoleucine, threonine, ornithine, leucine, serine, glycine, and asparasine and glutamine. The methionine and citrulline level declines also significantly. The total amino acids practically did not change. Physical exercise led furthermore to a marked increase of serum ammonia and uric acid. Urea nitrogen changed only little and on average had rather a declining tendency. The rise of alanine suggests the existence of a glucose-alanine cycle, the drop of ornithine and citrulline is most probably associated with the inhibition of ureogenesis in the liver. The reduction of leucine and isoleucine is probably the result of the entry of these amino acids into muscle and their deamination.

Adult↗
PubMed1976

Haemodynamics and myocardial metabolism in patients with obliterative coronary arteriosclerosis and tachycardia induced by pacing.

Fifty-three men with significant obliterative arteriosclerosis of coronary arteries were examined at rest, during and after pacing. Pacing induced both angina pectoris and depression of the ST segment in 38% of the patients; either angina pectoris or depression of ST segment, in 32% of the patients; the remaining 30% of patients were without symptoms or ECG signs of coronary insufficiency. Haemodynamic findings at rest, or during and after cessation of pacing were not different between these groups. Pacing increased heart rate, cardiac index remained unchanged, the stroke volume decreased, the left ventricular ejection time shortened. In both systemic and pulmonary arteries the systolic pressures decreased, the diastolic and mean pressures rose. The left ventricular end-diastolic pressure decreased. In 28 of the patients the myocardial metabolism was investigated. A close correlation was found between positive symptoms and ECG signs of myocardial ischaemia on the one hand, and metabolic signs on the other hand. Absence of angina pectoris and depressions of the ST segment during pacing does not exclude the presence of metabolic signs of ischaemia; an opposite finding is about three times less frequent. The study offers objective information about haemodynamics and myocardial metabolism before, during and after pacing, and represents an attempt of a simple classification of symptoms and signs of induced ischaemia.

Adult↗
PubMed1975

Ammonia and uric acid formation after rapid intravenous fructose administration to healthy subjects and patients with compensated cirrhosis of the liver.

To seven healthy volunteers, 12 and 24 g i.v. fructose were administered in the form of 20% solution at a rate of 4 g/min. After both doses, during the 10th min after the completed intravenous administration, a statistically significant increase of serum ammonia and serum uric acid occurred. After 24 g, the rise of the uric acid level remains significant during the 40th min after administration, while ammonia values return to the basal level. Increments of ammonia and uric acid are higher after a larger fructose dose. Under the same set-up and at the same rate, 24 g fructose were administered to eight patients with compensated cirrhosis of the liver. The rise of uric acid was practically the same as in healthy subjects similar to the rise of the ammonia level during the 10th min after administration. 40 min after administration, however, the ammonia level in cirrhotic patients remained significantly raised, as compared with the initial level.

Adult↗