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Biomedical subjects

V Brodan

Publications and source records attributed to V Brodan.

At least 73 records · Page 4Linked to original sources
PubMed1978

The effect of glucagon on free plasma amino acids in cirrhotics and healthy controls.

The effect on free plasma amino acids before and after infusion of 1 mg glucagon was studied at rest after an overnight fast in seven patients with compensated liver cirrhosis and in seven healthy controls. Total aminoacidaemia in cirrhotic patients is significantly higher than in controls. Elevated basal levels in cirrhotics are found particularly in tyrosine, citrulline, tryptophane, threonine, phenylalanine, and methionine whereas ornithine and serine levels are decreased. Save for the redox couple cystine-cysteine which increases, glucagon elicits an decrease in most amino acids that is proportionate to their initial level. Total aminoacidaemia decreases in controls and cirrhotics by 14.6 and 9.1 per cent respectively. Serum ammonia level rises significantly in both groups, urea increases only in controls, uricaemia remains virtually unchanged.

Amino Acids↗
PubMed1978

Amino acid metabolism in the heart muscle in subjects with ischaemic heart disease at rest and during pacing.

In nine patients with ischaemic heart disease at rest and during pacing differences of free plasma amino acids, lactate, ammonia and uric acid between arterial blood and blood in the coronary sinus (a-cs differences) were investigated. At rest one single significant difference was found, i.e. a positive a-cs difference in aspartate. During pacing significant positive differences were recorded in aspartate, glutamate, leucine and isoleucine and significant negative a-cs differences in cystine-cysteine, glutamine and aspartic acid and in alanine. Among the correlations between a-cs differences the negative relationship between lactate and alanine and the negative correlation between cystine-cysteine and leucine, isoleucine and glutamine is significant. There is a positive relationship between the a-cs difference of alanine and glutamine and between the differences of leucine, isoleucine and glutamate. The a-cs differences of ammonia and uric acid correlate negatively.

Adult↗