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Biomedical subjects

V Briese

Publications and source records attributed to V Briese.

At least 109 records · Page 6Linked to original sources
PubMed1984

[Secretory immunoglobulin A (S-IgA)/immunoglobulin A (IgA) ratio in cervico-vaginal lavage fluids].

Investigation of the immunoglobulins in the vaginal lavage fluids are semiquantitatively. The aim of the present study was to complete the semiquantitative S-IgA estimations with an "S-IgA/IgA" ratio. An antiserum against the secretory component (Anti-SC) and an S-IgA standard as well as an antiserum against the immunoglobulin A(Anti-IgA) and a serum IgA standard were used. The ratio was proved in vaginal lavage fluids from 5 fertile and 2 infertile women in the course of the menstrual cycle on days 8th, 11th, 14th, 18th and 24th. Progesterone, IgG and IgA were estimated simultaneously in serum samples. According to the "S-IgA/IgA" ratio patients were divided in 2 groups with values higher than 1 on the one side and with values lower than 1 on the other side. In cases with high "S-IgA/IgA" ratio an increased local antibody production and secretion is supposed.

Cervix Uteri↗
PubMed1983

[Relation of AFP and glucose in amniotic fluid].

On the strength of references to estimations of glucose in amniotic fluid carried out to support the prenatal diagnostic regime we have proved if there was a correlation between concentrations of alpha 1 fetoprotein (AFP) and glucose in course of gestational weeks 15th to 22nd. The glucose content was constant relatively. It couldn't be found any correlation between AFP and glucose. Low glucose levels were estimated in some pathologic cases.

Adult↗
PubMed1983

[Detection of pregnancy-specific beta 1-glycoprotein (SP1), of proteins of the "pregnancy zone" (PZ), of pregnancy-associated plasma protein A (PAPP-A) with 24-hour radial immunodiffusion. Detection of pregnancy-specific beta 1-glycoprotein (SP1) with turbidimetry. Current significance of the proteins].

The estimations of pregnancy specific beta 1-glycoprotein (SP1), pregnancy associated alpha 2-glycoprotein (PZ) and pregnancy associated plasma protein A (PAPP-A) in serum samples are useful for supervision of pregnancy and diagnosis of gestational diseases. In clinical practice simple inexpensive and short time methods are preferred. Two simple short time methods were described. The 24 hour radial immuno-diffusion (RID) was compared with the usual 48 hour RID in 30 serum samples of normal pregnant women. The SP1-values ascertained with the 24 hour RID and the 48 hour RID correlated with a high coefficient (r = 0.99). In ranges of high SP1-concentrations the correlation was decreased. The correlation coefficients for PZ and PAPP-A amounted to 0.89 and 0.925. The estimation of proteins with turbidimetry is a real short time method. This method was performed in 19 serum samples of pregnant women and the results were compared with the 24 hour RID. The correlation coefficient amounted to 0.81. Between the results of 24 hour RID for SP1 and PAPP-A there was no correlation.

Female↗
PubMed1983

[Concentration of serum globulins, pregnancy globulins, immunoglobulins and estriol in retroplacental blood].

Retroplacental blood samples were received after vaginal deliveries from 22 healthy primi- and multiparae aged between 20 and 30 years. Simultaneously venous blood samples were taken immediately after delivery. Pregnancy specific beta 1-glycoprotein (SP1), pregnancy associated alpha 2-glycoprotein (PZ), immunoglobulins G, M, A, secretory immunoglobulin A (S-IgA), alpha 2-macroglobulin (AMG) and unconjugated estriol were estimated quantitatively in venous as well as in retroplacental blood samples. The concentrations of SP1 in retroplacental blood were significantly lower compared with concentrations in venous blood, whereas estriol concentrations were significantly higher in retroplacental blood. All other factors differed not significantly. Only the IgM concentrations correlated in venous and retroplacental blood samples. The percentages of estimated proteins related to total protein content showed similar proportions in venous as well as in retroplacental blood. The relative protein content of SP1 was significantly lower in retroplacental blood than venous blood samples. The percentage of PZ was significantly higher in retroplacental blood. Among other things these increased concentrations of estriol and PZ in retroplacental blood be able to prevent the rejection of the trophoblast by the maternal endometrium.

Adult↗
PubMed1983

[Immunoglobulin M and alpha 2-macroglobulin in the amniotic fluid in neural tube defects].

Alpha 1-fetoprotein (AFP), alpha 2-macroglobulin (AMG) and immunoglobulin M (IgM) were estimated quantitatively in 16 amniotic fluid samples of gestational weeks 15 to 21. In 4 pregnancies there were defects of the neural canal (2 anencephalic fetuses, 2 fetuses with meningomyelocele). The other 12 amniotic fluid samples from normal pregnancies are used as control group. AFP, AMG and IgM concentrations were increased in the 4 pathologic samples. AFP was detected using Laurell-technique, AMG and IgM by single radial immunodiffusion.

Amniotic Fluid↗
PubMed1983

[Secretory immunoglobulin A in amniotic fluid].

Secretory immunoglobulin A (S-IgA) was estimated in amniotic fluid samples by means of the single radial immunodiffusion according to Mancini. A monospecific antiserum against human secretory component was used. 163 amniotic fluid samples from normal pregnancies and risk pregnancies respectively were investigated. Within the 3rd trimenon the S-IgA content in amniotic fluid increased significantly. With respect to literature and examinations performed previously a connection between S-IgA content in amniotic fluid and fetal lung maturity seems to be possible.

Amniotic Fluid↗
PubMed1983

[Secretory immunoglobulin A (S-IgA) in amniotic fluid and in pharyngeal mucus and urine of newborn infants].

S-IgA was estimated in amniotic fluid and in mucus samples of pharyngeal cavities and urine samples of newborns for assistance of the hypothesis that there is a connection between S-IgA content in amniotic fluid and fetal pulmonary maturity. It was used an antiserum against human secretory component and an S-IgA standard in the single radial immunodiffusion according to Mancini and coworkers. High S-IgA concentrations in the mucus samples of pharyngeal cavities refer to fetal bronchial-pulmonary system as the probable essential part in the synthesis of S-IgA established in amniotic fluid of the 3rd trimenon in pregnancy.

Amniotic Fluid↗
PubMed1983

[Secretory immunoglobulin A in the amniotic fluid of healthy pregnant females].

Amniotic fluid levels of secretory immunoglobulin A (S-AgA) were measured by simple radial immunodiffusion according to the method of Mancini using a monospecific antiserum against the human secretory component. 256 samples from healthy pregnant women were examined. Amniotic fluid S-IgA concentration increases significantly during normal pregnancy and shows a loose correlation to the phospholipid level.

Amniotic Fluid↗
PubMed1983

[Quantitative behavior of pregnancy-specific beta glycoproteins (Sp1) in the amniotic fluid in normal and pathologic pregnancies].

SP1 levels of 150 amniotic fluid samples from 70 healthy gravidae and 63 gravidae suffering from different disturbances of pregnancy obtained between gestational weeks 16 and 42 have been estimated by means of the simple radial immunodiffusion method. For this end amniotic fluid has been tenfold concentrated by lyophilisation. SP1 concentrations increase gradually during pregnancy, but individual differences are wide especially at the end of pregnancy. The regression line ascends. In the average, the SP1 concentration of amniotic fluid is 1 per cent of the serum values. Cases of rhesus isoimmunization and EPH-gestosis are often correlated with high amniotic fluid levels of SP1. However, the diagnostic importance is restricted by a considerable overlap of the confidence intervals. The significance of amniotic fluid SP1 as an additional parameter for risk pregnancies is, nevertheless, to be discussed.

Amniotic Fluid↗
PubMed1983

[Maternal serum IgA in intrauterine fetal growth retardation].

The problem was to prove the significance of IgA estimations in maternal serum samples with regard to the diagnosis and the monitoring of intrauterine fetal growth retardation. IgA was estimated in serum samples from two groups of patients. The first was formed from 62 serum samples of 14 primi- and multiparae delivered from new-borns with a birth weight below the 10th centile. The second was the control group. 82 serum samples from 18 gravidae were available. The IgA estimations were carried out by means of single radial immunodiffusion according to Mancini and co-workers. The IgA values of the two groups were different considering that linear regression model was used; negative correlation between IgA and pregnancy weeks in group with retarded new-borns (y = -151,78 X + 7579,8; r = -0,39) and positive correlation of these parameters in control group (y = 73,59 X -429,38; r = 0,26). It could be that IgA is an additional parameter within placental function tests of the 3rd trimester of pregnancy.

Female↗
PubMed1983

[Quantitative determination of secretory immunoglobulin A in the serum of patients with gynecologic tumors].

Secretory immunoglobulin A (S-IgA) was estimated by mean of single radial immunodiffusion and an antiserum against secretory component as well as an S-IgA standard in serum samples from 28 patients with fibroid, 18 patients with uterine cervix cancer, 8 patients with endometrium cancer and 4 patients with cancer of the vulva. 21 patients formed a control group. The average values were mean = 37,7 +/- 10,6 mg/l (control group), mean = 34,6 +/- 16,2 mg/l (fibroid), mean = 43,4 +/- 18,6 mg/l (uterine cervix cancer), mean = 43,3 +/- 20,0 mg/l (endometrium cancer). There were not significant differences between tumour groups and the control group. Some increased S-IgA values in the several groups were striking in the course of which we have not found any connection between the increased S-IgA values and the tumour stages as well as the histological tumour types. Moreover it was proved whether the posttherapeutical S-IgA values were changed in consequence of surgery or radiotherapy compared with values obtained before therapy values. Significant alterations were not ascertained with the t-test for compared observations.

Adult↗
PubMed1983

[Detection of secretory immunoglobulin A in cervical secretion and in cervicovaginal irrigation fluids].

Secretory immunoglobulin A (S-IgA) is an essential part of local immune system of female genital tract. Accordingly the estimation of S-IgA in female genital secretions is important for judgement of immunologic problems in female genital tract. The estimation of S-IgA was carried out by means of an antiserum against human secretory component (anti SC) and S-IgA standard. It was used the single radial immunodiffusion according to Mancini and co-workers. Our results refer to changes in the quantity of S-IgA locally produced in the mucous membranes of female genital tract correlated to the menstrual cycle. The essential results are a decrease of S-IgA in midcycle in cervical mucus and vaginal fluids as well as of fertile and sterile patients.

Adult↗
PubMed1982

Amniotic fluid secretory immunoglobulin A in normal pregnancy and in pregnancy complicated by rhesus isoimmunization.

Amniotic fluid levels of secretory immunoglobulin A (S-IgA) were measured by simple radial immunodiffusion according to the method of Mancini using a monospecific antiserum against the human secretory component. We examined 256 samples from healthy pregnant women and 149 samples from mothers suffering from rhesus isoimmunization. During normal pregnancy amniotic fluid S-IgA increased significantly and showed a loose correlation with the phospholipid levels. This was not observed in pregnancies complicated by rhesus isoimmunization.

Amniotic Fluid↗
PubMed1982

[Demonstration of immunoglobulins, glycoproteins and beta 2 microglobulin in ovarian cysts and cystic ovarian tumors].

Immunoglobulins G, M, and A as well as secretory immunoglobulin A (S-IgA), pregnancy-specific beta1-glycoprotein, pregnancy-associated alpha2-glycoprotein, and beta2-microglobulin were analysed in fluid samples which had been taken from ovarian tumours and ovarian cysts. High S-IgA values were established from mucinous tumours and from one endometrioid adenocarcinoma.

Adolescent↗
PubMed1982

[Estimation of secretory immunoglobulin A in serum of pregnant women (author's transl)].

Secretory immunoglobulin A (S-IgA) was measured by means of radial immunodiffusion, according to Mancini, with a self-made antiserum to the secretory component being used together with a S-IgA standard. S-IgA serum concentrations went up with significance in the course of pregnancy, which was probably attributable to increased production of secretory protein in the breasts in preparation for lactation.

Female↗
PubMed1982

[Detection of secretory immunoglobulin A in vaginal fluid of hysterectomised women].

Secretory immunoglobulin A (S-IgA) or the secretory component (SC) in vaginal fluid of hysterectomised patients were established by means of simple and double immunodiffusion, according to Mancini or Ouchterlony, using an S-IgA standard. Since S-IgA was recorded from vaginal fluid, general questions were raised for origin and transport mechanisms of this localised immunoglobulin.

Female↗
PubMed1982

[Detection of protein in cervicovaginal irrigation fluid with special reference to secretory immunoglobulin A].

Secretory immunoglobulin A is a major component of the local immune system of the female reproductive tract (S-IgA). Information on differences between S-IgA values in sexual maturity, on the one hand, and those recordable from postmenopausal women, on the other, is reported in this paper. Detection of S-IgA in the vaginal fluid of hysterectomised patients has given rise to the question for the existence of an immune system of the vagina proper. Cervicovaginal fluid rinsed from pregnant patients was examined, with comparison being made between concentrations of secretory A, G, and M immunoglobulin, pregnancy-associated alpha 2 glycoprotein, and pregnancy-specific beta 1 glycoprotein.

Cervix Uteri↗