[Avascular bone necrosis after renal transplant].
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Biomedical subjects
Publications and source records attributed to V Bonomini.
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The authors present 15 cases of hyp arthroplasty implanted in patients affected with necrosis of the femoral head, which were undergoing periodic hemodialitic treatment, or with renal transplants. Ceramic-ceramic prostheses were prevalently used and only in 1 case was a metal-polyethylene prosthesis used. Because of precarious mineralization a cemented prosthesis was implanted in dialyzed patients; in renal transplants, instead, cemented or cementless prosthesis were used depending on the state of the bone. There was a high percentage of excellent results after 2-8 years (87%), and this confirms the validity of surgical indications for the use of arthroplasty in hips affected with epiphyseal necrosis in order to favor functional recovery: considering the young age od the patients, this helps them to go back to being a part of society, and to recover psychologically.
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The history of renal replacement therapy is traced from the early days of dialysis and kidney transplantation through the era of miraculous technology and the alleged certainties of anti-rejection therapy. Attention is focused on the newly found or anomalous biotypes that are common to both dialysis and transplantation. In dialysis not only the patient but also uremia is maintained and either hyper- or hyporeactivity in different biological systems may occur with or without clinical symptoms. In transplantation, while the balance between immunomodulation and immunotolerance is far from ideal, extrarenal complications may occur with an atypical mode of presentation, serious immunological renal lesions may develop asymptomatically and clinical signs of rejection may appear without noticeable laboratory alterations.
A total of 18 hemodialyzed patients submitted to surgery for the treatment of carpal tunnel syndrome are examined. In all of the cases pre- and postoperative EMG and biopsy were performed. Six months after surgery all of the patients showed improved pain symptoms, in 66% there was good recovery of sensitivity and of the function of the hand: these results were confirmed by EMG monitoring. In all of the biopsies amyloid deposits, particularly diffused in the tendinous and nervous sheaths, were observed. At 2-year follow-up 75% of the patients showed recurrence of pain symptoms. Thus, surgery does not seem to definitively resolve symptoms.